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This web site is owned and operated by the accounting Viatta Business Ltd. HEXO+ Self-Flying Camera Drone, with a suggested retail price of brave, $1,249.00 USD («Main prize»). The Accounting! FreePage (single use) SMS inform (single use) Plagiarism Report (single use) 50$ to your bonus balance which you can use in 365 days 100$ to your bonus balance which you can use in 365 days. 2. Promotional Period. Movement Definition! The promotion begins on the accounting 7.18.2017, at eugenics definition 9:00 am and ends on 7.28.2017 at 10:00 pm. This Privacy Policy (“Policy”) describes how information about the accounting, You is collected, used and Bandwidth Essay, disclosed and provides other important privacy information, describes when and how we may change this Policy, and tells You how to contact us with any questions or comments. We collect information about You and computer(s) You use when You use our Services or otherwise interact with us. The Accounting Cycle! “Personal Information” means information that we directly associate with a specific person or entity (for example: name; addresses; telephone numbers; email address; payment information; device location etc.). “Client”, “User”, “You” and a song for solo voice orchestral accompaniment, “Your” refers to you, the the accounting person accessing this Website and eugenics movement definition, accepting these Privacy Policy.

Any use of the cycle above terminology or other words in the last of the the singular, plural, capitalization and/or he/she or they, are taken as interchangeable and the accounting cycle, therefore as referring to of blood same. HOW INFORMATION ABOUT YOU IS COLLECTED. We collect information about You in the accounting cycle three primary ways: Information You Provide. Rocket Moon! We collect information that You provide to us when You apply for and use and/or purchase our Services or otherwise communicate with us. The Accounting! For example, some of the a song voice with accompaniment ways You may provide information to us include: When You purchase our Services, the payment system will require your personal, contact, billing and the accounting cycle, credit information. Negative Effects Doping! When You establish or modify Your user account online, We may collect user identification information, passwords, and/or security question responses that You will use for the accounting future sign-on.

When You interact with our Customer Service representatives, enter information on work our Website, submit survey responses, or pay for the accounting Services, we may also collect Personal Information and Bandwidth Essay, other information. We may monitor and record phone calls, e-mails, live chats, or other communications between You and the accounting, our Customer Service representatives or other employees or representatives. Information We Collect Automatically. We automatically collect a variety of for solo with orchestral, information associated with Your use of our Services. The Accounting! Each time You visit the Website, Personal Information is Tax the Rich Essay example, automatically gathered. In general, this information does not identify You personally. The Accounting Cycle! Examples of brave, automatically collected personal information include, but are not limited to: IP address, Collection Date, Publisher Name, Connection Speed, Day of cycle, Week Time of Day (hour), Language settings, Country, City (relating to IP address, if available).

For example, some of the Bandwidth Essay ways we may automatically collect information include: Cookies and similar technologies. A “cookie” is the accounting, a small text file that a web site can place on eugenics movement Your computer's hard drive in order, for the accounting cycle example, to collect information about a song voice with orchestral, Your activities on the Website. The Accounting Cycle! The cookie transmits this information back to the Website's computer, which, generally speaking, is the only computer that can read it. A Song Voice Orchestral Accompaniment! We need to cycle use cookies on Tax the Essay the Website to enhance the cycle user experience and Tax the Essay, avoid multiple logins or password authentication requests. We may use, or we may engage third-parties to use on cycle our behalf, cookies or similar web tags (small data text files placed on definition your computer or device) or similar technologies to cycle identify Your computer or device and work by maya, record Your preferences and other data so that our Website can personalize Your visit(s), see which areas and features of our Website are popular, and improve our Website and Your experience. Depending upon the accounting, Your computer, You may be able to effects of blood set Your browser(s) to reject cookies or delete cookies, but that may result in cycle the loss of some functionality on orchestral the Website. The Accounting! We may also use web beacons (small graphic images on a web page or an Tax the Rich example HTML e-mail) to monitor interaction with our websites or e-mails. Cycle! Web beacons are generally invisible because they are very small (only 1-by-1 pixel) and the same color as the background of the web page or e-mail message. Web Browsing Activity.

When accessing our Website, We automatically collect certain information about Your computer and Your visit, such as your IP address, browser type, date and negative doping, time, the web page You visited before visiting our Website, Your activities and cycle, purchases on Bandwidth Essay our Website, and the accounting, other analytical information associated with the woman by maya angelou Website. The Accounting! Information From Other Sources. We may also obtain information about You from eugenics movement definition other sources. For example, We may receive credit information from the accounting third-party sources before initiating Your service. We may also purchase or obtain Personal Information (for example, e-mail lists, postal mail lists, demographic and marketing data) from others.

HOW WE USE INFORMATION WE COLLECT ABOUT YOU. Essay Example! We use the the accounting cycle information We collect for a variety of romare moon, business purposes, such as: To provide and bill for Services You purchase; To deliver and confirm Services You obtain from us; To verify Your identity and maintain a record of Your transactions and interactions with us; To provide customer services to You; To create, modify, improve, enhance, remove or fix our Services and the accounting, their performance; To identify and bearden rocket to the moon, suggest products or services that might interest You; To make internal business decisions about the accounting cycle, current and future Service offerings; To provide You customized user experiences, including personalized Services offerings; To protect our rights, interests, safety and property and effects, that of cycle, our customers, service providers and other third parties; and. Tax The Rich Essay! To comply with law or as required for the accounting legal purposes.

We may use Personal Information for movement definition investigations or prevention of fraud or network abuse. We may use information we collect to contact You about our and/or third-party products, services, and cycle, offers that We believe You may find of interest. Voice With Orchestral Accompaniment! We may contact You by telephone, postal mail, e-mail, or other methods. You may see advertisements when You visit our Website. We may help advertisers better reach our customers by providing certain customer information, including geographic information, language preferences or demographic information obtained from the accounting cycle other companies. A Song For Solo With! This information is cycle, used by angelou advertisers to determine which ads may be more relevant to the accounting You. Movement Definition! However, we do not share Personal Information outside of cycle, our corporate family for effects advertising purposes without Your consent. The Accounting Cycle! WHEN WE SHARE INFORMATION COLLECTED ABOUT YOU. We do not sell, license, rent, or otherwise provide Your Personal Information to unaffiliated third-parties (parties outside our corporate family) without Your consent. We may, however, disclose Your information to unaffiliated third-parties as follows: With Your Consent. A Song Voice Accompaniment! We may disclose Personal Information about You to cycle third-parties with Your consent.

We may obtain Your consent in writing; online, through “click-through” agreements; when You accept the terms of disclosures for Rich certain Services; orally, when You interact with our customer service representatives. The Accounting Cycle! We encourage You not to share Your password. If You provide Your user account password and/or security question responses to Tax the Essay example third parties they will have access to Your Personal Information when they access Your user account with Your account password. To Our Service Providers. We may disclose information to third-party vendors and the accounting cycle, partners who complete transactions or perform services on our behalf (for example, credit/debit card processing, billing, customer service, auditing, and marketing). In a Business Transfer. Tax The Essay! We may sell, disclose, or transfer information about You as part of the accounting, a corporate business transaction, such as a merger or acquisition, joint venture, corporate reorganization, financing, or sale of company assets, or in light the unlikely event of insolvency, bankruptcy, or receivership, in which such information could be transferred to the accounting cycle third-parties as a business asset in the transaction. For Legal Process Protection. We may disclose Personal Information, and other information about You, or Your communications, where we have a good faith belief that access, use, preservation or disclosure of such information is reasonably necessary: to a song for solo with orchestral accompaniment satisfy any applicable law, regulation, legal process or enforceable governmental request; to the accounting cycle enforce or apply agreements, or initiate, render, bill, and brave, collect for cycle services and products (including to Bandwidth Essay collection agencies in the accounting cycle order to bearden rocket to the moon obtain payment for our products and services); to protect our rights or interests, or property or safety or that of others; in the accounting cycle connection with claims, disputes, or litigation – in Tax the court or elsewhere; to facilitate or verify the the accounting appropriate calculation of the last brigade, taxes, fees, or other obligations; or. in cycle an emergency situation. Essay Example! We may provide information that does not identify You personally to third-parties for marketing, advertising or other purposes. HOW WE STORE AND PROTECT THE INFORMATION COLLECTED ABOUT YOU.

Protecting Your Information. We use a variety of cycle, physical, electronic, and Bandwidth Essay, procedural safeguards to protect Personal Information from unauthorized access, use, or disclosure while it is the accounting cycle, under our control. Unfortunately, no data transmission over negative, the internet can be guaranteed to the accounting cycle be completely secure. As a result, although we will utilize such measures, we do not guarantee You against the loss, misuse, or alteration of Personal Information under our control, and eugenics definition, You provide Personal Information to the accounting us at Your own risk. You should always take care with how You handle and eugenics, disclose your Personal Information and the accounting, should avoid sending Personal Information through insecure e-mail, social networks or other internet channels. Retention and Disposal. Negative Effects Of Blood Doping! We retain information only for cycle as long as we have a business or tax need or as applicable laws, regulations and/or government orders allow. Bandwidth Essay! When we dispose of Personal Information, we use reasonable procedures designed to the accounting cycle erase or render it unreadable (for example, shredding documents and wiping electronic media).

PRIVACY POLICY UPDATES. How We Communicate Changes to Bandwidth Essay This Policy. The Accounting Cycle! We may update this Policy at Bandwidth Essay any time to provide updates to or clarification of cycle, our practices. If we make changes we may provide You with additional notice (such as adding a statement to Rich example the homepage of our Website or sending You a notification). You should refer to this Policy often for cycle the latest information and brigade, the effective date of the accounting, any changes. This web site is owned and Rich, operated by Viatta Business Ltd . A Partner is an cycle individual who refers customers. A Referral is an individual who requests a service via the referral link given by a Partner. With the first order, a Referral acquires a 15% discount on the order, while a Partner receives $50 to Tax the Rich the Referral Balance. With further purchases, a Partner earns 5% of the the accounting Referral’s total order price. All money earned with the movement definition Referral Program is cycle, stored on your Referral Balance. Negative Effects! A Partner can transfer the money to the Bonus Balance and use it to cycle purchase a service.

It is definition, possible to the accounting transfer the voice with orchestral sum to the Partner’s PayPal account (no less than $20).

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resume monarchical NOTICE OF REVOCATION OF US INDEPENDENCE. NOTICE OF REVOCATION OF INDEPENDENCE (2000) The Revocation of Indpendence as executed by Alan Baxter Peter Rieden, 8 th Nov 2000, apparently inspired by the accounting an email sent by Dan Fox (who claims to brave, be the ultimate originator) or Kevin O'Connor (who also claims to be the ultimate originator). This version was compiled 21 st Nov 2000, compiled from several different versions. Early drafts, showing how it grew, are further down. Responses and related pieces are also included further down. Important note: The Revocation of Independence is NOT by John Cleese. During 2005, a version was wrongly attributed to the accounting, him and was circulated crediting Cleese as the author. He did not write it. It was present on of blood doping, Usenet and the Internet long before his name became associated with it.

To the citizens of the United States of America, In the light of your failure to elect a President of the cycle, USA and thus to govern yourselves, we hereby give notice of the brave new world love, revocation of your independence, effective today. The Accounting Cycle. Her Sovereign Majesty Queen Elizabeth II will resume monarchial duties over all states, commonwealths and brave, other territories. Except Utah, which she does not fancy. Your new prime minister (The Right Honourable Tony Blair, MP for the 97.85% of you who have until now been unaware that there is a world outside your borders) will appoint a minister for America without the need for further elections. Cycle. Congress and the Senate will be disbanded. A questionnaire will be circulated next year to determine whether any of you noticed. To aid in the transition to negative effects, a British Crown Dependency, the following rules are introduced with immediate effect: 1. You should look up revocation in the accounting cycle, the Oxford English Dictionary.

Then look up aluminium. Check the pronunciation guide. You will be amazed at just how wrongly you have been pronouncing it. The letter 'U' will be reinstated in words such as 'favour' and 'neighbour', skipping the letter 'U' is nothing more than laziness on by maya, your part. Likewise, you will learn to spell 'doughnut' without skipping half the letters. You will end your love affair with the letter 'Z' (pronounced 'zed' not 'zee') and cycle, the suffix ize will be replaced by the suffix ise. You will learn that the suffix 'burgh is pronounced 'burra' e.g. Edinburgh.

You are welcome to the last of the, respell Pittsburgh as 'Pittsberg' if you can't cope with correct pronunciation. The Accounting. Generally, you should raise your vocabulary to acceptable levels. Romare Moon. Look up vocabulary. Using the same twenty seven words interspersed with filler noises such as like and cycle, you know is an unacceptable and inefficient form of communication. Brigade. Look up interspersed. There will be no more 'bleeps' in the Jerry Springer show. The Accounting Cycle. If you're not old enough to cope with bad language then you shouldn't have chat shows. When you learn to develop your vocabulary then you won't have to use bad language as often. 2. There is by maya no such thing as US English. We will let Microsoft know on your behalf.

The Microsoft spell-checker will be adjusted to take account of the reinstated letter 'u' and the accounting, the elimination of -ize. 3. You should learn to distinguish the brave, English and Australian accents. It really isn't that hard. The Accounting Cycle. English accents are not limited to work by maya angelou, Cockney, upper-class twit or Mancunian (Daphne in Frasier). You will also have to learn how to the accounting, understand regional accents - Scottish dramas such as Taggart will no longer be broadcast with subtitles. While we're talking about regions, you must learn that there is doping no such place as Devonshire in England. The name of the county is cycle Devon. Bandwidth Essay. If you persist in the accounting, calling it Devonshire, all American States will become shires e.g. Texasshire, Floridashire, Louisianashire. 4. Hollywood will be required occasionally to Bandwidth Essay, cast English actors as the the accounting cycle, good guys. Hollywood will be required to cast English actors to play English characters.

British sit-coms such as Men Behaving Badly or Red Dwarf will not be re-cast and Bandwidth Essay, watered down for a wishy-washy American audience who can't cope with the the accounting cycle, humour of occasional political incorrectness. 5. You should relearn your original national anthem, God Save The Queen, but only after fully carrying out task 1. We would not want you to get confused and give up half way through. 6. You should stop playing American football. There is only one kind of football. What you refer to as American football is not a very good game. The 2.15% of you who are aware that there is Essay example a world outside your borders may have noticed that no one else plays American football. You will no longer be allowed to play it, and should instead play proper football. Initially, it would be best if you played with the girls. The Accounting. It is a difficult game. Those of you brave enough will, in time, be allowed to play rugby (which is similar to American football, but does not involve stopping for Bandwidth Essay a rest every twenty seconds or wearing full kevlar body armour like nancies). The Accounting. We are hoping to get together at Bandwidth Essay, least a US rugby sevens side by 2005.

You should stop playing baseball. The Accounting Cycle. It is not reasonable to host an event called the woman by maya, 'World Series' for a game which is not played outside of America. Since only the accounting, 2.15% of you are aware that there is a world beyond your borders, your error is understandable. Of The Light. Instead of baseball, you will be allowed to play a girls' game called rounders which is baseball without fancy team strip, oversized gloves, collector cards or hotdogs. 7. You should declare war on Quebec and France, using nuclear weapons if they give you any merde. The 97.85% of you who were not aware that there is a world outside your borders should count yourselves lucky.

The Russians have never been the the accounting, bad guys. Bandwidth Essay. Merde is French for 5hit. You will no longer be allowed to own or carry guns. You will no longer be allowed to own or carry anything more dangerous in public than a vegetable peeler. Because we don't believe you are sensible enough to handle potentially dangerous items, you will require a permit if you wish to carry a vegetable peeler in public. 8. July 4th is no longer a public holiday. November 8th will be a new national holiday, but only in England. The Accounting. It will be called Indecisive Day. 9. All American cars are hereby banned. They are crap and woman by maya, it is for cycle your own good. When we show you German cars, you will understand what we mean.

All road intersections will be replaced with roundabouts. Work Angelou. You will start driving on the left with immediate effect. At the same time, you will go metric with immediate effect and without the cycle, benefit of conversion tables. Roundabouts and metrication will help you understand the British sense of humour. 10. You will learn to make real chips.

Those things you call French fries are not real chips. Fries aren't even French, they are Belgian though 97.85% of you (including the woman, guy who discovered fries while in cycle, Europe) are not aware of woman by maya a country called Belgium. The Accounting. Those things you insist on calling potato chips are properly called crisps. Real chips are thick cut and fried in animal fat. Work By Maya. The traditional accompaniment to chips is beer which should be served warm and flat. Waitresses will be trained to be more aggressive with customers.

11. As a sign of penance 5 grams of sea salt per cup will be added to the accounting cycle, all tea made within the Commonwealth of Massachusetts, this quantity to be doubled for tea made within the brave new world, city of Boston itself. 14. The Accounting. You will learn to resolve personal issues without using guns, lawyers or therapists. The fact that you need so many lawyers and therapists shows that you're not adult enough to Essay, be independent. Guns should only be handled by adults. Cycle. If you're not adult enough to sort things out without suing someone or speaking to work angelou, a therapist then you’re not grown up enough to handle a gun. 15. Please tell us who killed JFK. It's been driving us crazy. Tax collectors from Her Majesty's Government will be with you shortly to ensure the acquisition of all revenues due (backdated to the accounting, 1776).

Thank you for your cooperation. (2000) ALAN BAXTER'S NOTICE OF REVOCATION OF INDEPENDENCE. From a company Intranet newsgroup and read: London, 8th November 2000. To the citizens of the United States of America, 2. Learn at least the the last of the, first 4 lines of God save the Queen 3. Start referring to soccer as football. 4. Declare war on Quebec. (2000) PETER RIEDEN'S NOTICE OF REVOCATION OF INDEPENDENCE.

The following is the the accounting, text of a message which was communicated to negative, President Clinton at 07:30 (EST) today: To the cycle, citizens of the United States of America from Her Britannic Majesty, Queen Elizabeth II. USANIAN FORM OF 15 POINT NOTICE OF REVOCATION OF INDEPENDENCE. November 8, 2000. To the Subjects of Essay Her Majesty, the Queen of cycle England, To the citizens of the United States of America: In light of your failure to brave love, elect anybody as President of the USA, and thus to govern yourselves and, by the accounting extension, the by maya angelou, free world, we hereby give notice of the revocation of your independence, effective today. Her Sovereign Majesty Queen Elizabeth II will resume monarchical duties over all states, commonwealths and other territories including New Jersey. To aid in the transition to a British Crown Dependency, please comply with the following acts: 1. Look up revocation in the now official Oxford Dictionary.

Start spelling English words correctly. 2. Learn at least the first four lines of God Save The Queen. 3. Start referring to soccer as football. 4. Declare war on Quebec and France. 5. Arrest Mel Gibson for treason. 6. Close down the National Football League. Learn to the accounting, play rugby.

7. Rocket To The Moon. Enjoy warm, flat beer and steak and kidney pudding. 8. Train waitresses to be more aggressive with customers and not to tell you their names before you eat. 9. The Accounting. July 4th is no longer a public holiday; this has been replaced with Nov. 5. 10. All members of this British Crown Dependency will be required to take six weeks annual vacation and observe statutory tea breaks. 11. Brave. Driving on the left side of the road is now compulsory. Recall all vehicles to effect the change immediately. 12. The Accounting Cycle. Report to our Consulate General in New York for your new passport and job allocation.

13. Have Meg Ryan report to Prince Andrew's bedchamber. 14. Add the royal insignia to the top of the Washington Monument and the Queen's Christmas speeches to the Lincoln Memorial. 15. Stop referring to the World Series of Baseball and woman, instead call it the National Series of the accounting cycle USA, Cuba and Japan.

Tax collectors from Her Majesty's Government will be with you shortly to Tax the Rich Essay example, ensure the cycle, acquisition of all revenues due (backdated to 1776). Thank you for romare to the your cooperation and have a nice day. (2000) REPLY TO THE NOTICE OF REVOCATION OF INDEPENDENCE. November 8, 2000. To the Subjects of Her Majesty, the Queen of England, In the light of the accounting your failure to effects, prevent us from kicking you out in the 18th century and doing as we damn well please, we hereby notify you that you can keep it down over there before we take notice. Sure, historically America really doesn't pay much attention to the rest of the world. But when someone does catch our eye, we tend to carpet bomb them to a pre-industrial state.

It may not be right, or fair, but it is a trend. I suggest you keep it in mind. Cycle. To aid in your realization that you should pipe down, the following facts are listed: 1. American English is distinct from British English. Our aluminum is a lovely silver color, and we do not 'armour' our tanks, thank you. 2. Work Angelou. When you can tell the difference between an Alabama and Louisiana accent, I'll pay attention to the difference between a Londoner's and cycle, a Yorkshireman's accents. 3. Bandwidth Essay. Rather than God save the Queen; you should learn The Battle Hymn of the Republic.

After all, if it weren't for the accounting American soldiers you'd speak German today, twice over. And if it weren't for American bread, butter, etc., you would have been starving while we saved your little old island from the Hun. 4. If I were to throw an American football block on football player, he'd be out negative effects of blood of the the accounting cycle, game and I'd be ejected. If I were to throw a real tackle on a rugby player, he'd be maimed. Negative Effects Doping. The pads in American football are to keep you from being crippled or killed.

Just because rugby players tear their ears in a group hug called a 'scrum'doesn't make them tough. You want tough? You put YOUR arms in theair while a 322 pound (46 stone) man slams into the accounting cycle you at a dead sprint and still catch the ball. That's tough. 5. If you can't settle the French's hash, find someone else. Bandwidth Essay. After all, they have lost to everyone *but* the the accounting cycle, British this century.

6. The irony of a Brit complaining about American cars is too much. Bandwidth Essay. I've driven British cars and they're like a Hyundai, but poorly made. When someone else comes up with an idea as good as the muscle car, we'll think about it. To sum it all up, we really aren't interested in the accounting, your opinion. Another immediate response from the US mentioned something about Rich Essay a large shipment of Tea (the Boston Tea Party for cycle those not required to study US history). Then there was this . The Supreme Court of Florida has instructed me to post the brigade, following to ensure strict balance in these turbulent times.

DECLARATION OF ANNEXING THE BRITISH ISLES AS PART OF THE USA. To the imperialist British colonizers. In the light of your indecision over joining a common European Currency, your dissatisfaction with the European Union, your bickering with European Governments and the fact that you already almost speak our language and cycle, refuse to speak any other European languages, you are to be annexed as a State of America. Your state code will be GB. Zip codes will be assigned to replace your old postal districts. The state capital will be Stratford-upon-Avon which is a lot prettier than London. Princess Diana will be declared a saint. Bearden Rocket Moon. You have already assimilated so much American culture that you are unlikely to notice the transition. To aid in cycle, the assimilation, the following rules are introduced with immediate effect:

1. Look up aluminum in any good American Dictionary. Bandwidth Essay. Check the spelling and the accounting cycle, pronunciation guide. We discovered it, we named it, you are mispronouncing it. Learn to live with it. You are, of course welcome to your idiosyncratic and illogical place-names such as Edinburgh, if you wanted it pronounced 'Eddinburra' you have spelled it that way in negative effects of blood, the first place. You will quit using words such as fortnight. The Accounting Cycle. The correct term is a two week period.

You will learn words such as credenza, intern and the last of the, chad. 2. There is no such thing as UK English. UK English is the relic of a defunct colonialist power which attempted to impose British English linguistic superiority on a nation which has a higher number of English speakers. 3. Your film-makers should learn to distinguish the American and Canadian accents. American accents are not limited to redneck drawls or New York accents. Mainland Americans have more than enough accents to cope with in our own country, so all British dramas will now bear subtitles, especially those made in impenetrable dialects such as Scottish, Scouse or Geordie. To make life easier for mainland America, all British films and the accounting, TV programs must use American vocabulary and accents; Scotch characters will wear plaid, Irish characters will have shamrocks on them, Welsh characters will not be used since we don't have Welsh Americans, and English characters will wear bowler hats and pinstripes. 4. The British film industry will no longer portray all Americans as cowboys, rednecks, trailer trash or Beverly Hills billionaires. Hollywood will continue to use Mockney and Posh British accents as this makes it easier for viewers to identify which characters are British. Romare Bearden To The. You can have Hugh Grant back.

He's a lousy actor and we don't want him either. Cycle. All British films will be made in Hollywood where the weather and scenery are better. Your film industry is already unable to woman work by maya angelou, make a halfway-decent film which doesn't contain a American in the starring role. All American characters should be 'good guys'. 5. You will learn your new national anthem The Star Spangled Banner.

It shall be sung every morning at the accounting cycle, kindergarten, high school, university and your places of work. Your Union Flag will be hung up any damn way we wish so stop bitching about it being upside down. If there was meant to Tax the Rich example, be a right way up you should have made it simpler. All Union flags will be replaced by the Stars and Stripes over a 12 month period of time. 6. You should stop playing soccer and rugby. There is no need to cycle, have two games, one of which is confusingly like Football and one of which is light called football but patently isn't real football. If it doesn't require 45 pounds of padding, it isn't football.

You should also stop playing cricket. Americans can't understand the rules. If you insist on playing this game which is only played by former British colonies, you will introduce a simplified scoring system, timeouts, colored strips and the accounting, cheerleaders to make it more interesting. Any match which takes longer than 90 minutes will be declared a draw. 7. In films, as in real life, we decide who the Bandwidth Essay, bad guys are.

The bad guys are those guys who don't do as we tell them. They are also the the accounting cycle, guys who attract the biggest audiences into movie theaters. Of The Light. You will cease using the word cinema. They are movie theaters. The snippets of cycle forthcoming films are not trailers they are teasers. 8. Love. November 5 th is the accounting no longer a day for fireworks. July 4th is the appropriate fireworks festival. If you want a big fireworks party on November 5 th , we will help you to rocket to the moon, blow up your Houses of the accounting cycle Parliament.

You won't be needing them any longer; Disneyland London will be situated there. Hunting with packs of dogs is also banned. Negative Effects Doping. Instead, you will go hunting with a pick-up truck, some six-packs of beer, two coonhounds and enough guns and the accounting cycle, ammo to equip a private militia. There is romare also no such activity as caravanning. It is properly called camping. The thing boy scouts do with tents and the accounting, bedrolls is called tenting. 9. Roundabouts will be banned.

What is the Bandwidth Essay, point of cycle turning left in order to woman work, turn right? They are confusing to Americans and the accounting cycle, are death traps. You will start driving on negative of blood doping, the right with immediate effect. Most of the world drives on the right already. You will be allowed to cycle, turn right on a red light if safe to do so though you must check local county legislation as this is not permitted in all areas. 10. Those things which you call chips are cholesterol-soaked abominations. You will start to eat fries - light fluffy potato in crisp coating. To The Moon. If you want to eat British-style fried potato sticks you will need a certificate from your doctor and good medical insurance. Beer is to be served cold.

The warm, flat drink you call beer is properly termed 'ale' and the FDA have determined it to be unfit for human consumption. The Accounting. You will also learn the difference between crackers, cookies and biscuits to avoid causing unnecessary confusion to mainland Americans. 11. Work By Maya. All inter-personal communications between family members, even if resident in the same house, must be through a lawyer. It is compulsory to sue somebody at least once per year - be inventive. It is compulsory to have therapy three times each week and to the accounting, recover false memories of your childhood which allow you to sue your parents and/or your therapist. Therapy will take the the last brigade, place of cycle speaking to negative effects of blood doping, family members. The Accounting. You will be given compulsory courses on how to brave, become dysfunctional.

Name your children after interesting medical conditions. 12. You will not have guns. In the eyes of Mainland Americans you are wayward children. Children are not permitted to play with firearms unless they have a legitimate reason to do so i.e. they plan to gun down the population of a small town (self-defense) or slaughter every living creature within a mile radius (hunting). Thank you for your co-operation. Cycle. You will be assimilated.

Footnote: Resistance is futile. Just ask Hawaii. By the way, Ireland and Scotland should be separate states. They have entirely different cultures and languages from the Norman fops. To avoid supporting third world countries and welfare states (the reason for Bandwidth Essay NOT annexing Mexico), Canada, Australia, New Zealand, should become independent nations. The Falkland Islands should become an American Protectorate like Puerto Rico, Samoa, The Philippines, Guam and other places that are neat to vacation. Cycle. America should take back Hong Kong immediately. TO THE CITIZENS OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND:

We welcome your concern about our electoral process. It must be exciting for you to see a real Republic in action, even if from a distance. The Last. As always we're amused by your quaint belief that you're actually a world power. The sun never sets on the British Empire! Right-o chum!

However, we regretfully have to the accounting cycle, decline your offer for intervention. On the other hand, it would be amusing to see you try to enforce your new policy (for the Bandwidth Essay, 96.3% of you that seem to have forgotten that you have little to no real power). After much deliberation, we have decided to the accounting, continue our tradition as the longest running democratic republic. It seems that switching to Bandwidth Essay, a monarchy is in fact considered a backwards step by the accounting the majority of the brave new world, world. To help you rise from your current anachronistic status, we have compiled a series of helpful suggestions that we hope you adopt:

1. Cycle. Realize that language is an organic structure, and that you aren't always correct in your pronunciation or spelling. Let's use your aluminium example. Essay. Sir Humphrey Davy (an Englishman) invented the name aluminum (note spelling) for the metal. However, in common usage the name evolved into aluminium to match the naming convention of other elements. The Accounting. In 1925 the United States decided to switch back to the original spelling and of blood, pronunciation of the word, at which point we dominated the aluminum industry. The Accounting Cycle. We'd also like to point out that the process of the last of the light brigade actually producing aluminum was developed by cycle an American and the last of the, a Frenchman (not an Englishman). However, we'd like to thank you for the Oxford English Dictionary. It's an interesting collection, considering that over 10,000 of the words in the original edition were submitted by a crazy American civil-war veteran called Dr. William Charles Minor. 2. Learn to distinguish the American and Canadian accents, and then we'll talk about the English and Australian accent issue. 3. Review your basic arithmetic. (Hint 100 - 98.85 = 1.15 and 100 - 97.85 = 2.15)

4. If you want English actors as good guys, then make your own movies. Don't rely on cycle, us for your modern popular culture. We liked Lock, Stock, and Two Smoking Barrels, Trainspotting, and The Full Monty. We've also heard good things about this Billy Elliot. But one good movie a year doesn't exactly make a cultural powerhouse. However, you're doing pretty well with music, so keep up the good work on of the brigade, that front. 5. It's inefficient to have a national anthem that changes its title whenever your monarch dies. Let's not forget that your national anthem has an the accounting cycle, extremely boring tune. New World. We suggest switching to that Rule Brittania ditty, it's toetapping. The Accounting. Or maybe Elton John could adapt Candle In The Wind again for you guys.

6. Improve at your national sport. Football? Soccer? This just in: United States gets fourth place in men's soccer at the 2000 Summer Olympics. United Kingdom? Not even close. Of Blood Doping. By the way, impressive showing at Euro 2000. You almost managed to get through the tournament without having your fans start an international incident. 7. Cycle. Learn how to cook. England has some top notch candy. Salt 'n' Vinegar chips are quite yummy.

However, there's a reason why the romare bearden moon, best food in your country is the accounting Indian or Chinese. Your contributions to the culinary arts are soggy beans, warm beer, and spotted dick. Perhaps when you finally realize the Tax the Rich Essay, French aren't the spawn of Satan they'll teach you how to cook. 8. You're doing a terrible job at cycle, understanding cars. The obvious error is that you drive on Tax the Rich Essay example, the wrong side of the road. The Accounting. A second problem is bearden to the pricing, it's cheaper to buy a car in Belgium and ship it to England than to the accounting, buy a car in England. On the other hand, we like Jaguars and Aston Martins. That's why we bought the companies. 9. We'll tell you who killed JFK when you apologize for Teletubbies. Thank you for your time. Negative Effects Of Blood. You can now return to watching bad Australian soap operas.

PS: regarding WW2: You're Welcome. BILL CLINTON'S LETTER TO LIZ WINDSOR. The following was received from cycle, David Simpson of Fletcher Greenwood Co. I received it on 21st Dec 2000 in response to this history, but it is dated 13th November. FROM: Bill Clinton. TO: Her Britannic Majesty Queen Elisabeth II. SUBJECT: Revocation of the last light brigade American Independence. DATE: November 13th 2000.

Ole George, Your Great Great Great Great Great Great Grand Pappy said we'd screw up over here in the Colonies and it's finally happened. This time it's got nothin to do with me, at least that's what my advisors say. I have really tried to cycle, stay outta the news and away from the babes to help Gore but he's no Goddamn use anyhow. He screwed up by himself this time. We'd agreed those ballot papers in Palm Beach cos we were tryin to romare bearden to the moon, confuse the hell outta the Republican voters. The Accounting Cycle. Guess that one back fired. So, 'bout this notice sent out sayin' you're reclaimin the colonies and takin over, well, we kinda feel it's cute you'd wanna have us back after all this time. One concern though, 'bout those back taxes, we need time to pay. Pretty soon I aint gonna have a job. I know Hillary' got a well-paid position now but she won't wanna have much to do with me soon. She's still mad at me 'bout Monica.

Every time I light a cigar she still cries and throws stuff. As for woman by maya angelou the national anthem. Well I was kinda wondrin if you'd let me play it on the Saxhorn for the accounting cycle you sometime, it's been a while since I've had a good blow, but I'm practicing an' hopin'. Had a word with the boys at the Pentagon 'bout nukin France and Quebec. They said it'd be no problem but are kinda worried the EU might renegade on the banana deal we worked out through the WTO. Also said somethin about a nuclear winter but guess it's close enough to Christmas for a bitta snow anyhow. You know Liz, one of the romare rocket to the, requests does kinda suck. We like our football and the advertising guys are hoppin mad about the possible loss of income. They say soccer, sorry football don't have enough breaks to fill it up with advertisements and the accounting, that folk'll get bored. I gotta agree on this one Liz, for the sake of the American people, sorry, new British Subjects, I gotta stand my ground here. Anyhow, gotta go blow the horn with Monica and get learnin' this new tune.

Oh one more thang, don't suppose Tony could give me a job could he? DECLARATION OF THE COMMONWEALTH OF AUSTRALIA ON TAKING CHARGE OF THE AFFAIRS OF THE ENGLISH SPEAKING PEOPLES. The following announcement was found in a corrugated iron outhouse West of Alice Springs -- some fecal matter has been removed but the Bandwidth Essay, text is still fairly clear, despite the beer stains. When, in the course of cycle human events, it becomes clear that major powers have turned into circus acts, it becomes necessary for somebody to sort out the ensuing shambles. We won't even mention politics, just an internationally accepted yardstick for brave new world love national ability, the Olympic Games.

Since the USA can't organize an Olympic Games without making a shambles of the the accounting, business, and since the UK hasn't had a competitive Olympic team since 1908, then Australia has an love, overriding claim to cycle, national superiority. It remains true, of course, the US Olympic team won the most medals in the last games, whilst Australia came fourth, but that only proved that on a population basis it takes eight times as many Septic Tanks to win an Olympic gold medal as it takes Australians. Work. It therefore becomes Australia's duty to take charge of those nations who still know where their barbecues are kept. Washington and London will now take their guidance from Canberra. Canberra used to be an the accounting, excellent cow paddock but became the brave new world love, site of the the accounting, political capital of Australia, which means there's far more bullshit there now than there ever was before. An address will be provided to those that need to communicate with the Australian government: one side of a postcard only please, and replies can be expected within a year or so. In the meantime, please obey God's eleventh Commandment to the Aboriginals: don't do a thing until I get back to you. Political lobbyists will need to Tax the Rich example, bring their own swags, billies and bush tucker until extra accommodation can be provided. (See below: Waltzing Matilda). Visitors can also expect to cycle, find themselves being sprayed with insecticide by customs officials when arriving on Australian soil.

As a courtesy to incoming guests we always provide the brave, first layer of fly repellent free of cycle charge. The other sixty five daily applications are your responsibility. You have our permission to say the word 'aluminum' any way you wish. Since Australia is the world's largest supplier of bauxite we don't give a shit what you call it, just as long as you keep making the stuff. Place names in all English speaking countries from now on should be clear, simple and woman work, straightforward for all English speakers. Please write for an advisory leaflet from the Australian Centre for Sensible Place Names, Rabbitflats House, Rum Corp Road, Woolloomooloo, Sydney, New South Wales. Americans should be aware that a Chad is a traditional UK/Australian cartoon character. He has a big nose, a single strand of curly hair and is always drawn with only the upper half of his face visible over a brick wall.

Equally traditionally, Chad is always saying: Wot! No . Only the last word is altered to suit the the accounting, occasion. At present, of course, the inscription would read: Wot! No President? A piece of paper punched out of a ballot paper is love technically known internationally as shit-for-brains, since everybody else in the world has a population which is capable of drawing an cycle, X on rocket moon, a ballot paper. Only laboratory monkeys and American voters make decisions by hanging on handles. However the incoming Australian administration doesn't want to make too many radical changes. Simply be aware that in future the US and the accounting, UK will be required to follow Australian voting procedures and that from now on it is Bandwidth Essay a criminal offence for a citizen not to vote.

Or at the accounting, least it's an offence not to attend a voting station. What you do in negative of blood, the booth is up to you. But at least there's no need to the accounting, spend any more time and money in trying to brave, persuade voters to turn out. We, in turn, will abandon the proportional representation system. This system of voting was invented by the accounting cycle the British mathematician who also wrote Alice In Wonderland. Not surprisingly, the results are always a Mad Hatter's Tea Party. We have no intention of altering anybody else's variety of English, though personally, I'm agog to know how you meet with somebody.

Either you meet them or you don't. There are of course cultural differences to be bridged but they can be done so profitably. For example, street kids in the US who deserve jail terms will instead be compelled to watch a four day cricket match and to negative of blood doping, answer questions afterwards: our own juvenile delinquents will be forced to watch the entire collection of Letterman shows and then to try to explain why the audiences laughed at any part of them. The Australian Minister for the accounting cycle Culture has ordered that from work by maya angelou, now on all Hollywood films have Australian directors. Furthermore, they must also be joint Anglo-American productions, as that seems to be what it takes to make a decent movie nowadays. Notting Hill and Shakespeare in Love for example. We also demand a re-make of cycle Dr Strangelove starring Bruce Willis: the highlight of the film is the last of the going to be when he gets dropped out of a B-52 riding on top of a nuclear bomb. Only this time it's going to be a real A-bomb and no stuntmen allowed: now die hard, you untalented prick! Oh yes, and all films are to be shot in Australia, where we have the the accounting, sort of weather California thinks it has. We also have the best of everything else, including women, and at half the brave love, price in the States. The Accounting. The Australian film industry also wants Mel Gibson back -- we're going to put him out to stud.

There is no need to change your national flags. All that is required is that you fly them below a pair of Elle McPherson's knickers, preferably used. The new international anthem, of course, is Waltzing Matilda. As you are aware, all other national anthems are about the superiority of brave new world one country over all other countries. Waltzing Matilda is about a sheep thief getting caught by the accounting cycle the cops. It is therefore an anthem to private capitalism and stock option dealings in a marginal legal situation: Wall Street and the London Stock Exchange should both be proud to sing it out loudly every morning. From now on the only code of football which will be allowed in negative, international matches is Australian Rules Football.

American football looks like a bunch of the accounting cycle panic stricken plane handlers fighting to get off the woman angelou, deck of a sinking aircraft carrier: UK football looks like a gang of kids trying to pass the time in the yard of the accounting cycle a school for the mentally retarded. Australian rules football is the game the angels play: it's where the big men fly. Please be aware that in Australian English, to 'root' for a team means to new world, have sexual intercourse for it, or with it. We're not trying to stop you from doing anything you want to, just making sure you understand your options. Cycle. Gay males should also be aware that scoring a behind in Aussie Rules is not what you might have hoped it was. After some considerable thought it has been decided to retain the Monarchy to rule over the English speaking world, but to make it more relevant to the present realities. Bill Gates will therefore be crowned King Geek The First. Hell, he owns most everything, so we might as well make it official. There's no point in building him a palace as he already lives in negative of blood doping, one, so Buckingham Palace will be turned into the accounting cycle a backpacker's hostel for young Australians visiting the Former UK -- or Fukland, as it will have to be renamed. The House of Commons will be required to spend one day a week picking up empty beer cans from the Palace Gardens. Which means we'll get at least one day's useful work every week out of the sods.

Of course it's not interesting to have a King as dull as Bill I without any drama being injected into the Court. So he'll need a Vizier, just like in the Arabian Nights' Stories, as evil as Viziers traditionally are, a mendacious, cunning, word twisting, untruth telling Vizier, a duplicitous dog of Bandwidth Essay a Vizier, a Vizier whose instincts are wolfish, savage, bloody, ravenous and the accounting, starved. Woman Angelou. Rupert Murdoch has been approved by cycle Australian central casting for the part. The duties of Vice Vizier are to new world love, be carried out by Homer Simpson. True, he's a cartoon character, but cartoon characters have been installed in the US Vice President's Office for years and only Gary Trudeau noticed. You will be advised in due course whether King Geek II will be a carbon or silicon based lifeform. The question of cycle which side of the road to drive on has been settled fairly. From midnight to twelve, it's on the right, from Bandwidth Essay, twelve to midnight it's on the left, and every alternative Thursday when there's a 'r' in the month and a full moon you can drive during the cycle, hours of darkness directly along the top of woman work angelou any white line you fancy.

If in doubt, please contact Robert Hughes, the well known Australian art critic and cycle, road safety expert. Unfortunately, but in line with world opinion, we are going to negative doping, have to the accounting, insist on woman work angelou, the cessation of capital punishment for criminals. However, we are prepared to strap offenders to an electric chair and force them to eat a Vegemite sandwich: if they decide they'd rather have the current turned on instead that's their choice. Vegemite is cycle technically a yeast extract but to non-Australians tastes something like what your great grandparents might do if you dug them up, scraped some of the residue off the coffin walls and put it between two slices of bread. But although consuming Vegemite is of the not compulsory, all non-Australian citizens will be required to eat shark in their fish and the accounting, chips. Except for lawyers, who are excused on the last brigade, the grounds of professional courtesy. Of course all non-Australian beer is to cycle, be immediately poured away down drains and replaced with real beer: beer as cold as liquid oxygen, beer with more punch than Mike Tyson, beer which biteth like a serpent and negative effects doping, stingeth like an adder, beer you can taste three blocks away from the the accounting, pub. All the Milwaukee slops can go back into the barmaid's apron they were squeezed out of and as for British beer . Some dissension has arisen over cultural festivals and when is a suitable holiday to let off fireworks. Since we have no such days on our own calendar we Aussies have decided the romare bearden, best thing to cycle, do is to light brigade, hand Northern Ireland over to the US as the 51st state.

After all, Washington seems so interested in getting a peace deal there that it might as well have the place. The idea is that the cycle, British get to new world love, let off their fireworks when the last British soldiers leave Ireland, and the Irish factions will supply the US Peace Keeping forces with fireworks enough thereafter. Of course there are arguments that America is too powerful and too rich have any outside system imposed on the accounting, her, and also that Americans are too proud to truckle to any kind of a King. These arguments are, of course, specious. Too powerful? kicked out of Southern Vietnam, bombed out of the light brigade of the Lebanon, self defeated at the accounting cycle, Desert One, ejected of Ethiopia, not quite up to snuff for brave new world love a ground war in cycle, Kosova, unfortunately unavailable for woman angelou East Timor, scuttled by a rowing boat. What's the matter, can't you find somebody your own size? Or are you saving up the US Army to stand guard along the Tex-Mex border as part of Dubya's new approach to foreign policy? Too rich? Don't like Kings? Well, there's one monarchy the Americans will always fight for and that's the Saudi one. And everybody in the accounting, the West knows why.

If Saudi Arabia stopped selling oil the CLOSED signs would go up on gas stations right across the states and the West would have an economic down turn which would make the 1930's Depression look like just a bad day at the office. Which is the real reason why Australians are desperate to see this Presidential farce settled. Look, our Prime Minister is not exactly a charismatic super star. He could get lost in a crowd of of the two. Our Leader of the Opposition looks like a stranded whale in cycle, a suit. But they're both smart enough to know that if the US keeps on supporting Israel in the Jews' totally ruthless suppression of the the last of the, Palestinians there's eventually going to be a reaction from the Arab masses. The day that Omar Bin Laden becomes the the accounting, President of the Peoples' Democratic Republic of Saudi Arabia is a day nobody in the West wants to see. But unless somebody can rein those Israeli imperialists in there will be a revolution in the Arab countries and Allah alone knows who'll be in charge when the smoke clears. Right now we need somebody in the Western world who'll give the Jews the straight news: you want to fight the entire Muslin world, you do it on your own.

We don't know you, we're not subsidizing your army, and we're not going to risk our oil supplies to keep the Jewish voters in the United States happy. Essay Example. But that's not a message that Gore or Bush would ever dare deliver -- not until it's too late. But they're all that we've got, and we haven't even got one of them yet. No wonder everybody else in the accounting cycle, the West is screaming in frustration. The Americans will still be squabbling away in brave new world, the courts over a bunch of geriatric generated votes until the streets of enemy occupied Palestine are filled with dead Arabs -- and when somebody lets off a suitcase nuclear bomb somewhere in revenge the only response from Washington will be more brainless screams of outrage about the accounting cycle terrorism. As far as I can see President Clinton has made honourable efforts to brave, avert a looming disaster in cycle, the Middle East. But now the Ringmaster is the last light leaving and all we've got left are two clowns taking turns at kicking each other's butts. America and the world needs better, much better, than America has been able to come up with this time around. The Accounting. And now it looks as if everything which has made the US a great country is bearden rocket to the moon going to be dragged through the filth of the courts by a bunch of cycle low life lawyers. (2000) NEW ZEALAND VERSION OF THE NOTICE OF REVOCATION OF INDEPENDENCE. This version, giving the negative doping, USA to the accounting cycle, the Maori people, circulated on 20th November 2000.

To the citizens of the United States of America: In the light of your failure to elect a President and thus to govern yourselves properly, Her Sovereign Majesty Queen Elizabeth II has revoked your independence, effective immediately. However, she will not govern you herself because the Maori of New Zealand have claimed ownership of the USA. Tax The Rich Essay Example. There is the accounting cycle ample evidence that Maui discovered America after setting out from the ancestral homeland, Hawaiiki, in the wrong direction. Under the Treaty of Waitangi all Maori land that was illegally taken by the Crown will revert to Maori ownership. Ngai Tahu will resume administrative responsibility for negative effects all states except Florida, which they do not fancy.

Your new governor, Sir Tipene Oregan, will appoint a ministers to look after your affairs without the the accounting, need for further elections. Congress and the Senate will be disbanded. Bandwidth Essay. A questionnaire will be circulated next year to determine whether any of you noticed. To aid in the transition to an Aotearoa-New Zealand Dependency, the the accounting, following rules are introduced with immediate effect: 1. Woman By Maya. You should look up revocation in the Oxford English Dictionary. Then look up aluminium. Cycle. Check the pronunciation guide.

You will be amazed at just how wrongly you have been pronouncing it. Generally, you should raise your vocabulary to acceptable levels. Look up vocabulary. Using the to the, same twenty seven words interspersed with filler noises such as like and you know is an cycle, unacceptable and inefficient form of communication. Look up interspersed. 2. Effects Doping. There is no such thing as US English. Cycle. We will let Microsoft know on your behalf. 3. You should learn to distinguish the New Zealand and Australian accents.

It really isn't that hard. 4. Hollywood will be required occasionally to cast Russell Crowe and Tem Morrison as good guys. 5. Effects Of Blood Doping. You should relearn your new national anthem, God Defend New Zealand in English and Maori, but only after fully carrying out the accounting cycle task 1. Tax The Rich Example. We would not want you to get confused and cycle, give up half way through. 6. All MacDonalds and Burger King outlets will be closed down, and you will purchase fush and chups, but only when you can pronounce them properly. 7. Any whales stranded on beaches will be the property of Ngai Tahu, and to the moon, Sir Tipene must be notified immediately. 8. You will stop playing American football. It is a dreadful game. The 2.15% of you who are aware that there is a world outside your borders may have noticed that no one else plays American football. You will no longer be allowed to play it, and should instead play proper football ie. rugby, which is similar to American football, but does not involve stopping for a rest every twenty seconds or wearing full body armour like poofters. Initially, it would be best if you played in the women's competition. It is a difficult game, but with training you should be able to the accounting, get together at least a US rugby sevens side by 2005.

9. You should declare war on Quebec and France, using nuclear weapons if they give you any merde. 10. July 4th will no longer be a public holiday. November 8th will be a new national holiday, called Indecision Day. 11. All American cars are hereby banned. They are crap and it is for Bandwidth Essay your own good. When we show you Holdens, you will understand what we mean. 12. Please tell us who killed JFK.

It's been driving us crazy. 13. Failure to comply with the cycle, above will be taken very seriously and result in the severest of punishments - Roger Douglas will be put in charge of your economy, and romare rocket to the moon, it will serve you right. Thank you for your co-operation. (DATE UNDETERMINED) CANADIAN VERSION OF THE NOTICE OF REVOCATION OF INDEPENDENCE.

To the cycle, citizens of the United States of Tax the Essay America. 1. In the light of your failure to elect a President of the cycle, United States, and thus govern yourselves, we hereby give you notice of the Revocation of your Independence, effective today. 2. Her Sovereign Majesty Queen Elizabeth II will resume monarchical duties over all States, Commonwealths and other Territories; with the the last brigade, exception of Utah, which she does not fancy. 3. Your new Prime Minister, The Rt. Hon. The Accounting Cycle. Tony Blair MP, for the 97.85% of woman angelou you who do not know that there is a world outside of your borders, will appoint a Minister for America without the cycle, need for further elections. 4. Congress and the Senate will be disbanded. A questionnaire will be circulated next year to determine whether any of woman work by maya you have noticed. 5. Cycle. To aid in woman by maya angelou, the Transition to a British Overseas Dependency, the following rules are introduced with immediate effect.

i. You should look up “revocation” in the Oxford English Dictionary. Then look up the word “aluminium”. Check the pronunciation guide. You will be amazed at just how wrongly you have been pronouncing it. ii. Generally you should raise your vocabulary to acceptable levels. Look up “vocabulary”. Using the same 27 words interspersed with filler noises such as “like” and “you know” is an unacceptable and inefficient form of communication. Look up “interspersed” iii. The Accounting Cycle. There is no such thing as “US English”. Tax The Essay. We will let Microsoft know on your behalf.

iv. You should learn to distinguish between the English and Australian accents. It really is the accounting not that hard. v. Hollywood will be required to brave, occasionally to the accounting, cast English actors as the “Good Guys”, and effects of blood, Canadian actors not as Americans with funny accents. vi. You should relearn your original National Anthem, “God Save the Queen”. This is to be carried out only after Task 1 is completed, as we do not want you to get confused and give up half way. vii. All Law Enforcement Agencies will be replaced with the Royal Canadian Mounted Police, who are very used to clearing up after your mess, and cycle, dealing with your criminal intent.

They do reserve the right to shoot you just because you are American. viii. Example. You should declare war in Quebec and France, using nuclear weapons if they give you any Merde. The 98.85% of you who are not aware that there is a outside of your borders should count yourselves lucky. The Russians have never been the the accounting cycle, “Bad Guys”. Merde is the French word for *beep* ix.

July the 4th is no longer a Public Holiday. November the 8th will be a new National Holiday, but only in England and Canada. This will be called “Indecisive Day”. x. All American cars are hereby banned. They are crap anyway, and it is for your own good. You will understand when we show you a German car.

xi. Please tell us who shot JFK. We know it’s one of you but it’s been driving us nuts for years! 6. The preceding points are to be put into effect immediately. Any questions regarding the Transition or its benefits, please contact Canada or Australia, as they have the entire system in order. 7. Thank you for your co-operation. NOTICE OF RECIPROCAL COLONIZATION. Mark Simkiss wrote I wrote this around the US election and new world love, was happy to cycle, have seen it floating around the Internet at the time. Work Angelou. I find the whole thing particularly interesting being an American of the accounting cycle both English and Irish decent, and the humor of the whole thing makes me smile every time I read any of the Bandwidth Essay, emails related to cycle, the situation. Also, as you'll notice, there is romare rocket to the a link at the end which is a pretty good resource for US/UK vocabulary.

It's pretty funny in fact, even if it is only 70% accurate in my best estimation. To those with the the accounting, ability to read English, moreover, to speak it and have one’s accent understood, and to those for whom humor is seen in humor and woman by maya, humour, this is the American response to mum’s response to the accounting, our dilemma in Bandwidth Essay, America. NOTICE OF RECIPROCAL COLONIZATION. To the citizens of the the accounting cycle, United Kingdom of Great Britain and love, Northern Ireland, to the Commonwealth of Nations, including, but not limited to, Canada (which is the accounting cycle already a state, excluding Québec), Australia, New Zealand, Bermuda, Jamaica, etc., and any other nation lacking the inspiration to create for themselves a national flag not resembling the Union Jack: In light of the fact that although America stands firmly on her own two feet, this nation has been formed with ideas derived from the last of the brigade, some of the children of the best free thinkers in 17 th century Great Britain, and has been rooted in such. Therefore, the citizens of the the accounting cycle, United States of America hereby impose the following decree as our birth rite: 1. Like our mother has previously done, the citizens of the United States of America now impose unilateral colonization upon light, the above fore-mentioned nations, which are for this day forward to be deemed and to which referred, Colonies of the United States of America. 2. As mum taught us best, none of the Colonies shall have any representation in our globally expansive government, however, fear not as they will be taxed thrice as heavily as any of the members of the Original Fifty States, and this shall be deemed a privilege. 3. All currency in ridiculous color-coded Monopoly board game pastels shall be destroyed and the accounting cycle, replaced with the work by maya, correct currency colors of green, black, and the accounting, white. Failure to forfeit such will be treated as both servile insurrection and romare rocket moon, submission of the accounting testimony on one’s behalf to illiteracy and need for color to brave new world love, sort one’s purse.

4. The President of the both the United States of America and her Colonies shall be determined by the residents of the cycle, state of by maya Florida consisting of mostly senior citizens, expatriated Canadians, Cuban refugees, and in the future – the now disbanded British Royalty. Cycle. This will be deemed a fair representation for brave all. 5. English will be removed as the official language of the former UK and the former Commonwealth of Nations as well as the the accounting cycle, like for English and French in Canada. The Colonies will conform to the United States’ policy of no official language as the English language is to be enriched with the words of the world, not purified of new world love them. 6. The Accounting Cycle. Police will no longer be called Bobbies in Tax the example, the UK. The appellation of toque for a cap or hat will be forbidden in Canada. Words spelled like centre will not be removed, but restricted. The Accounting Cycle. In this instance centre shall mean a physical place, where center shall mean the middle. 7. The Original Fifty States will concede a small token in good faith and instate the metric system.

8. The Oxford English Dictionary shall be renamed the Harvard-M.I.T. Dictionary of the Global English Language. 9. Excluding the incontrovertibly inevitable linguistic derelicts of any society, all members of the Colonies shall be required to keep a vocabulary on par in volume with that of the current average American of the day, and not simply Standard Received English as is spoken by many Geordies, Scots, Welsh, Nova Scotians, and Southern States Americans. 10. Obsolescent pronunciations such as roit for effects right, ad-ver-tiss-mint for advertisement, which by the way will pick-up a ‘z’ to replace the ‘s’ in the accounting cycle, the former American spelling, shall be banned. 11. Any citizen of America or her Colonies caught speaking the letter ‘z’ as ‘zed’ shall be latched into the town center’s stocks, head and hands, for brave the townspeople to mock. 12. The citizens of America’s Colonies, with the exception of Canada, shall be required to actually read the spelling of cycle ‘aluminum’ as used in the Original Fifty States, to conceptualize how it is brave new world love not said with ‘-inium’ as the ending pronunciation.

These individuals will be screened as per items number three (3) of this list. 13. The Accounting Cycle. The existence of ‘types’ of English shall be abolished. All English, e.g. U.S. English, U.K. English, Canadian English, etc., shall be called English, with the Bandwidth Essay, exception of Scots English, which will now be called Greek. 14.

The second level of all buses, a.k.a. lorries, coaches, etc., will be removed. 15. The Accounting. Education will commence to eradicate the jousting gene from the citizens in romare bearden rocket to the moon, Colonies where the medieval idea of driving on the accounting cycle, the left still exists, including the U.S. Virgin Islands. 16. American Football will keep its status as ‘Football’ and English Football will become ‘Soccer’ universally throughout the Colonies. This means France will have to change to Le Soccer or Le Soc. 17. There will be no more warm beer, and the citizens of the Colonies will no longer be subjected to watered-down macro beers such as Budweiser and Miller.

Real American beer will be had by all. 18. Everyone in the former British Isles shall be required to see an orthodontist on a regular basis. 19. Time shall be referred to as the following: WDC + 05:00 in London. 20. Of The. The new states of England, Scotland, Wales, British Columbia, Alberta, Saskatchewan, Manitoba, Ontario, Québec, Nova Scotia, Newfoundland Labrador, Price Edward Island, New Brunswick, Nunavut, Western Australia, Northern Territory, Queensland, New South Wales, Victoria, South Australia, Tasmania, New Zealand, Antigua, Barbados, Bahamas, Belize, Salomon Islands, St. Kitts Nevis, St.

Lucia, St. Cycle. Vincent the Grenadines, South Africa, Trinidad Tobago, and Western Samoa shall each receive a star on the flag to represent their statehood. In addition, the Northwest Territories and the Yukon Territory will be renamed the state of Arctic and Bandwidth Essay, the state of Yukon, respectively - each receiving a star to represent their statehood as well. The Accounting Cycle. Finally, Puerto Rico, American Samoa, the U.S. Virgin Islands, and Guam shall all be granted statehood and issued a star on the flag. The other thirty-four (34) remaining members of the former Commonwealth of Nations shall be disbanded with the option to apply for statehood within ten (10) years. 21. Hong Kong will be returned to romare bearden rocket, Colony status - we do not bow to China.

22. As of the accounting November 21, 2000, 57% of Americans from the Original Fifty States were proficient in more than one (1) language, representing 157,691,225 people speaking two (2) or more languages and over 90,000,000 who speak a language other than English at brave, home. All Colonies will be required to maintain that 50% of their territorial population can speak more than one (1) language, with the exception of Quebec, where, due to the prevalence of French, 80% of the cycle, inhabitants shall be required to be bilingual or better. 23. Of The. The Colonies will now be permitted to cycle, purchase the good American cars and will no longer be restricted to the bottom of the line models, as is bearden to the prominent in Europe. 24. Outside the Original Fifty States and the former Canada, the numbering system shall be reorganized as such: 000 = thousand; 000,000 = million; 000,000,000 = billion; 000,000,000,000 = trillion; 000,000,000,000,000 = quadrillion, and so forth. 25. Measuring your weight in stones will only be permitted when inebriated. 26. (Now-defunct link to humour article about America) - This site is only about the accounting 70% accurate but humorous. 27. Work By Maya. (Now-defunct author email address) - send me a note.

The preceding was authored by Mark J. The Accounting Cycle. Simkiss, Jr. Effects Doping. -- an American of both English and Irish decent. REAL ESTATE SALE - UNITED STATES. In the light of the American people's inability to elect a new president, the British Government have revoked the Declaration of Independence. Her Sovereign Majesty, Queen Elizabeth II, has placed the USA on the real estate market. Monies raised shall contribute to the upkeep of the British Monarchy. So far, land has been allocated to the following parties by Royal Decree: ENGLAND. Wish to reclaim and retain their original East Coast territories e.g. The Accounting. New England, Massachussetts, Virginia etc etc.

These parts were colonised in the time of Queen Elizabeth I so it would be neat if they were reclaimed by Queen Elizabeth II. Any exceptions to this are as noted below and are granted out of Her Majesty's generosity to fellow European nations. We don't actually want to live in these places, you understand and, in due course, we will ship out our unemployed or undesirables to these states since Australia won't accept them any more. THE NETHERLANDS. New York was originally called Nieuw Amsterdam and will revert to that name. The term yankee is negative doping derived from the Dutch Jan Kees (John Cheese - a generic person) and the willingness of the accounting certain parties to call themselves or others Yankees is the bearden rocket, manifestation of a subconscious desire to return to being a Dutch territory. With rising water levels due to global warming, the Dutch want a place which will still be above sea level in 10 years' time. NORTHERN IRELAND. Since the US is the accounting so damned interested in Northern Irish affairs and has bigger St Patrick's Day celebrations than the Irish in their native country, it seems sensible to relocate the Irish to Utah (demonstrating that Her Majesty has a sense of humour). A state will be bought for them as a gift from the British Government. To avoid any residual inconveniences to Britain, both Northern Irish and Southern Irish shall be relocated.

They'll fit right into the gun-culture and it will save on postage costs for NORAID. Vacated Ireland will then be used for resettlement of Eastern European immigrants into the UK. ISRAEL. The votes of American Jews are so valuable that the US supports poor beleaguered Israel in order to please this portion of the American voting population. Rather than fight over a little bit of desert stuck in the middle of a bunch of Muslim countries, it seems sensible to simply relocate all Israelis to the last, America. Jerusalem can be recreated in the accounting, Hollywood where it will be bigger and woman angelou, better than the original without the cycle, inconvenience of being a war-zone. Jerusaland will be a theme park in Southern Florida. Romare Bearden Rocket. Since all Israelis do National Service in the Army, they will provide an immediate police/security force - and cycle, one without obesity problems.

Israel will therefore have most of Southern Florida, excluding Miami which will go to Cuba. CUBA Will get Miami, Florida. They currently have it in all but name. And with only one party on the ballot paper, they are unlikely to screw up on elections. REDNECKS The Rednecks will be allocated Northern Florida, Georgia, Alabama, and the Carolinas.

No-one else wants to brave love, live there. Incest and cycle, trailers will be mandatory in these states. CANADA. They're only next door so Her Majesty is going to award them 'that scruffy bit of brave new world land next to cycle, their back yard' and ask them to get it decently under control. That way, they can let Quebec declare independence or sell itself to France and woman work angelou, not be inconvenienced by the accounting the loss of a scrap of land. QUEBEC As a goodwill measure, Quebec will get Louisiana which is Cajun country. No-one else wants the place since the staple diet of crayfish is considered unfit for human consumption. In winter, they can all close up Quebec and head south to warmer climes.

Quebec/Louisiana will be renamed 'North Arcadia' and new world, 'South Arcadia'. FRANCE Will be co-owner North and South Arcadia. MEXICO. The number of legal and the accounting cycle, illegal immigrants into the US makes parts of the bearden rocket, US Mexican by default. Spanish is becoming the main language in many parts and Hispanics the main ethnic group. Might as well make it official. Cycle. No-one's going to Bandwidth Essay, notice the difference. Mexico therefore will get Texas, Nevada and California - they already have these in all but name. The Pacific Ocean will eventually claim coastal California anyway. ITALY New Jersey will go to Italy who already control it anyway via the mob.

Only the paperwork remains to be filed . JAPAN They will get Hawaii … at long last. Sumo wrestling will be the Hawaiian national sport. TEXACO Have put in a bid for Alaska. However, Alaska will be returned to the Russians who sold it to the US for a pittance. They can then sell the oil on the accounting cycle, to Texaco and of the light, get the Russian economy going again. GERMANY Germany will get Wisconsin and Pennsylvania. The Pennsylvania Dutch are in fact of German origin. The Accounting Cycle. Pennsylvania will be turned into a special reserve (a living museum) for reclusive religious orders which shun the trappings of modern life such as Shakers, Amish and Pennsylvania Dutch. UNITED NATIONS Will take control of all American Armed Forces. We mean the real armed forces, not the private militias. Woman. Private militias are, of course, free to apply to Sierra Leone where there are plenty of employment opportunities, unless of the accounting course you are racist in which case South Africa may be more appropriate.

That way the UN-controlled US Forces can come along and beat the sh*t out of you just like they've always wanted to do, but never been allowed to do. ARYAN NATION Aryan Nation will get Idaho. Idaho will become a white supremacist state. All non-whites will be given massive resettlement packages after which a 15 feet high razorwire fence without gates will be erected around Idaho and it will become a no-fly zone. Private militias, gun-crazed radicals and supremacist groups can then use the place to their hearts' content. It will be a closed state so they can only wipe out each other due to having no-one else to wipe out. Once they've successfully wiped out bearden to the each other, Idaho will be put on the market again.

NATIVE POPULATION A bit of South Dakota will be allocated in perpetuity to the American Indians. The Accounting Cycle. They will also get Manhattan Island back. Oh wait, isn't that a part of Nieuw Amsterdam which is already allocated to the Dutch? They will instead have the rights to romare rocket, graze horses and hunt on Manhattan Island. But we'd like our beads back please. ANNHEISER-BUSCH Annheiser-Busch will end up with Missouri whether they want it or not. ILLEGAL ALIENS An alien is an extraterrestrial. A person from another country is a 'foreigner' not an 'alien'. Get that fact wrong at your peril since any American who believes s/he is an alien or an the accounting cycle, alien/human hybrid will be shipped off-planet immediately for interplanetary immigration offences.

After that, it's up to you to find your way back to your planet of origin or get your parent to come pick you up. Any American wishing to Bandwidth Essay, opt out of this deal by being abducted by aliens is free to do so. The Accounting. Only don't come crying to Her Majesty about implants, rectal exams or unbreathable atmospheres. MISCELLANEOUS REQUESTS UNDER CONSIDERATION ACT UP would like San Francisco. Norway will have Minnesota, please and anywhere coastal that they can hunt whales. Microsoft will have Washington State. Bill Gates will have the big White place, please. Intel will have Oregon. Ford want Michigan.

MENSA LAUNCHES CHAD SPECIAL INTEREST GROUP. EXPATRIOT TIMES, London, England, 10th November 2000. Following the US Election, the American branch of Mensa, the society for those with high IQs, today announced a new Special Interest Group (SIG). Due to popular demand we're launching a SIG for punching holes in pieces of paper, said a spokesperson for American Mensa, It will be called the Chad Opinion Group (COG). We plan to have an new world, online 'Chad-room' where our members (COGnescenti) can exchange views about hole-punching and we produce a monthly newsletter devoted to Chadding Techniques. It's a very emotive issue - the relative merits of clean-cut chads, pregnant or dimpled chads, hanging chads, chads in paper, cardboard and other materials and any other type of the accounting chad you care to Tax the Rich Essay, mention. All types of Chad-enthusiast will be welcome just so long as they qualify for Mensa membership. Whether you only ever punch holes during elections or whether you're a filing clerk who punches holes every day, just so long as you have a high IQ you can subscribe to this SIG. When accused of 'dumbing down' Mensa, their spokesperson said, We are simply moving with the times. The Accounting. There's a great deal of interest in chads right now and the Florida ballot papers proved that you need a high level of intelligence to punch out chads properly.

Commenting on the suggestion that Mensa-level intelligence is required for hole-punching, Darrin Antrobus, now living in Rich Essay, the UK, said This is so true it hurts. GEORGE W. BUSH FINAL ACCEPTANCE SPEECH. My fellow Armenians, As I stand here today looking over cycle this magnificent viagra, I think we can agree that the Bandwidth Essay, past is over. Cycle. Our country is ready for a fresh, bipolar approach. I want to bring America together. We are the hill shining on brave, a city, and the accounting cycle, each of us can get to the top if we set our feet to it. Americans have made their decision. Brave. They don't need sympathy; they need ablutions. We need to move on beyond the petty armadilloes.

Politics doesn't have to be the way it is today. We can make the pie higher. A high pie lets everyone put food on their family and the accounting cycle, their family on the table. Bandwidth Essay. That's my record: I side with the people. And the cycle, B-side of my record is by maya Billy-Joe Gibbs and the Shoeshine Boys singing Streets of Laredo. A president has to think not only of himself and his family and his baseball team's families, but all American families. I don't believe a president should be choosing who are the right Americans and the accounting cycle, who are the wrong Americans. All of us together, white or wrong, black or right. Bandwidth Essay. Or perversely. That's why my tax cut is as broad as we are. The Accounting Cycle. And it will give our expansion a timely dose of wind.

I say there is a cost to inaction. I haven't done the acrobatics, but it's probably around a trillion dollars. That's a good round sum to of blood doping, offer to everyone, especially our seniors who are the the accounting, backache of our nation. Bearden To The. I would like to the accounting cycle, take a moment to mention my mother, Barbara Bush, who taught me to read and write when I was still knee-high to a lawnmower. Doping. We need our seniors to be free to pass on their life's work to those they love, and especially to pass on. Thanks, Mom and Dad. We know America is the the accounting cycle, best in the world. We are the great super-premium; we cannot afford to be unleaded.

This is still a world of madmen and mental losses. And mental loss is easy to underestimate. Work Angelou. We need a sharpened sword to light our way. To quote Ronald Reagan: I do not believe in a fate that will fall on us if we do nothing. I do believe in a fate that will fall on us if we do something. And it must never run our lives. The purpose of prosperity is to make sure the cycle, American dream touches every killing heart. Progress can be slow; you measure it in inches and feet, not miles or kilograms.

Or cantilevers. I worked in Texas by common sense and plain dozing. I got on with small business because I was one myself. I'm less now. But I'm also more. We are all less and brave love, more. Cycle. More or less. And I believe we must match our compassionate hearts with out preservative minds.

I know you would rather be watching TV, and so would I, so I will draw to a confusion. My message is: I will get things done. I will inspire and untie. The Last Of The Light Brigade. I will appeal to people's better angles. I will prove that politics can be bigger than you ever thought possible. We will trust the people we serve, and serve the people we trust. Together we can do what needs to be done to preserve this great bastard of cycle freedom. Thank you and brave new world, God help America.

(via email; believed to originate from December issue of The Economist) (2004) USENET VERSION 1. Direct Communications Unit. 7th Floor, 50 Queen Anne's Gate. London, SW1H 9AT. RE: Revocation of the accounting cycle your Independence. In the light of Rich example your failure to elect a proper President of the USA and thus to govern yourselves, we hereby give notice of the revocation of your independence, effective today. Her Sovereign Majesty Queen Elizabeth II will resume monarchial duties over the accounting all states, commonwealths and other territories.

Except Utah, which she does not fancy. Your new prime minister (The Right Honourable Tony Blair, MP for the 97.85% of you who have until now been unaware that there is a world outside your borders) will appoint a minister for by maya angelou America without the need for the accounting cycle further elections. Congress and the Senate will be disbanded. New World Love. A questionnaire will be circulated next year to the accounting cycle, determine whether any of you noticed. To aid in the transition to a British Crown Dependency, the following rules are introduced with immediate effect:

Rt Hon David Blunkett. (2004) USENET VERSION 2. Official messages from her Majesty, Queen Elizabeth II of England to all Americans: In view of your failure to elect a proper and Tax the Rich, semi-intelligent president of the United States in two straight elections and showing you are now incapable of the accounting governing yourselves, The queen hereby gives formal notice of the revocation of moon your independence, effective immediately. The Accounting. Her Sovereign Majesty, Queen Elizabeth II will assume duties as your monarch and supreme ruler over all states and territories except for Arkansas, Tennessee, Alabama and Florida which her Majesty considers either too vile or senile to bother with reforming. Her Majesty will appoint a royal governor that shall be responsible for all other states. Since you can not vote intelligently or decide matters of state, both houses of Congress, the supreme court and obviously the office of of the brigade president are disbanded effectively immediately.

The country formally known as the cycle, United States, now a laughingstock in the eyes of the world is now reabsorbed into the British empire from which it came. To aid in Bandwidth Essay, the transition to a British Crown Dependency, the the accounting, following rules will take effect next Monday. 1. All American flags will be burned and replaced immediately with the union jack, official flag of the Tax the Essay example, United Kingdom. 2. The armed forces will report to Prince William. The Accounting. Prince Charles will become Secretary of brave Defence, other posts to cycle, be filled by members of the royal family to be announced shortly. 3. All will be required to woman angelou, learn ballroom dancing, eat mutton every Tuesday, fish and chips on Fridays and come to appreciate warm beer. 4. The Accounting. All Americans will become citizens of the British crown and will bow in woman work by maya angelou, my presence. 5. All American holidays except for New Years and Christmas are revoked to be replaced by holidays celebrated in the UK. 5. All wages, incomes, properties will be taxed at 30% of value with all proceeds forwarded to the UK yearly. 6. The Accounting Cycle. Starbucks will replace coffee with twenty flavours of British tea.

The Queen expresses regret for taking such drastic measures, but since half of Americans never bother to Tax the example, vote and the other half twice in a row decided to vote for a blithering idiot that by the way the last time he visited wrecked my rose garden with his helicopter and goons running all over the accounting cycle the queen's official gardens and never even saying he was sorry, the Queen has no choice but to revoke your sovereignty since it is Bandwidth Essay clear too many Americans have taken leave of their senses. (2004) USENET MINOR VARIANTS. There were some variant openings for the two main versions (above): In light of your failure to make the correct decision in electing your President, thus showing you to cycle, be unfit to the last light brigade, govern yourselves, we hereby give you notice of the revocation of your independence effective as of Monday 8th November 2004. [etc] In the cycle, light of your failure to elect a sane President of the United States and thus to govern yourselves with consideration for the rest of world, we hereby give notice of the Revocation of your Independence, effective immediately . Angelou. [etc]

To the citizens of the United States of America, in view of Prime Minister Tony Blair becoming President of all he surveys, we hereby give notice of the revocation of your independence, effective today. (2004) RESPONSE FROM THE USA. The main response circulated was largely the cycle, same as in doping, 2000: DECLARATION OF ANNEXING THE BRITISH ISLES AS PART OF THE USA. (2004) (ANOTHER) US RESPONSE TO THE REVOCATION OF INDEPENDENCE. While we Americans might have taken this little joke of yours badly, we have recognized it for what it is: a cry for cycle help. We realize that you are tired of being a third-rate little country on your own. Therefore we shall bring you into the fold as our 51st state. Woman Work Angelou. There will be some changes:

1. The Accounting Cycle. An unprecedented road-building initiative shall commence immediately. Check out the light, interstate system in the US. You'll see why this is needed. We will probably bring in Germans to do this. Cycle. Looking at you present system of transport there seems to woman work by maya, be nothing to recommend English engineers. 2. Cycle. Everyone will be issued with an automobile.

Once you realize that commute of over brave new world love 30 minutes in a country this size is unacceptable, you'll thank us. 3. Cycle. Squads of bitter, overweight, ex-high school, and college athletes will be shipped over to instruct you on winning. In short, winning is everything. Coming in third place consistently and congratulating yourselves on being good sports is stupid. Wake up. (We also believe this pedantic infatuation with language may be due to your loser status. Giving you something to feel good about.)

4. You will no longer be allowed to mention the Second World War. It was the last thing you won, but it was over fifty years ago. 5. You will now be allowed to express your feelings when you want. If someone cuts in front of you in line - queue is a silly word and romare to the moon, is henceforth outlawed - you are now allowed to kick his ass or shoot him. That's part of the accounting cycle being an American: choices and handguns. Bandwidth Essay. You're really going to the accounting cycle, like this. 6. The English tradition of getting in line will probably go out of style once the romare bearden rocket, stores are open twenty-four hours a day, seven days a week, and actually have what you're looking for at a price you can afford. This is a lot to the accounting cycle, take in. Breathe slowly and take it a little at bearden to the moon, a time. 7. Soccer is out the the accounting cycle, window. Let's face it, sitting around for Bandwidth Essay two hours watching a bunch of guys not score points is infuriating.

That's why you kill each other over the accounting cycle it. 8. The Spice Girls will be executed. By Maya. No discussion. Things that will not change: 1. The monarchy will remain much as it is today. We think it's cute. The Accounting Cycle. However we will tax them. Anybody that rich can afford it. 2. You can keep ignoring the metric system, but maybe do it a little more proactively like the brave love, rest of the States.

Let's face it. Do you really want your kids using something the French came up with? 3. The English accent will remain intact. We like the cycle, sound of it, even if you do use a lot of silly words. Congratulations on your ascension to Rich Essay, these heady heights. (2004) THE BRITISH REJECTION OF THE REVOCATION OF INDEPENDENCE. Upon reflection, Her Majesty's Government has decided that the British no longer want America. For a start, we do not wish to lower our average IQ. The Accounting Cycle. To allow distinction between Britain and America the following should be implemented forthwith: 1. The English language is English as the name English suggests; new dialects made from the non-English are to woman by maya angelou, be banned. The English decide how the English language is to be spoken.

As no Americans know how to speak English, we think it best for you to make up your own language - you’ve nearly done so already. It’ll be easier than learning correct English. We advise that the creation of the new language American should be left to the few of you with IQs larger than 60. English will now be studied as a foreign language at all stages of the American education system; you may just learn it that way. Your country does not have a higher number of English speakers, what you are speaking is not actually English. There is cycle no such nationality as Scotch; it is Scottish. Don’t complain about how we depict you when you don’t even know what we’re called. 2. Hollywood is to Essay example, acknowledge what really happened in all war films. Cycle. You did not have the bearden to the moon, U-571 mission. That was the British.

We Were Soldiers is to have a new ending. Don't even get us started on The Patriot. You did not win Vietnam; the films should show this. Hollywood is to the accounting, create 10 films of what America did wrong in wartime, we all make mistakes, no wonder you are all big-headed. 3. Sports are from now on allowed no padding. We can cope without it, you will be surprised to find that no other country uses it and it is not necessary. We created the first football, so we decide what is football.

Your sport football is doping now called American Women’s Rugby. Basketball will be called Men’s Netball. When you have realised that less padding is better, bouncing the ball will not be allowed. In Hockey only the the accounting, goalkeeper will wear pads, and you are only allowed to hit with one side of the stick. Cricket will be taught from an early age; while adults can’t understand it, the children might still develop an IQ. 4. The Star Spangled Banner is to be used as the theme tune for Sesame Street.

The existing one is a little too intelligent for American children. As for the adults, the Tax the Rich Essay, Sesame Street theme tune is on the accounting cycle, the same level as your intellectual abilities and is now your National Anthem. If you come back with some smart-arse comment about Sesame Street’s theme tune, it will just prove that you watch it. Think carefully. 5. Teletubbies was intended for children's television. If you can’t cope with it try to make some other childish programmes yourself. 6. Adverts can only be shown twice every 30 minutes on television.

TV is for programmes not advertising. Shopping channels will be merged with ordinary stations; this will reduce your advertising, your credit card debts, and the cost of Tax the Essay your cable bill. 7. Again, we made beer, so we decide what it is. American Budweiser is cycle not beer; beer tastes good. 8. In the next US election you will vote for someone who has the mental age of at least 12. It’s not much, but improvements should be gradual. If you elect someone with a mental age of more than 18, each of angelou those that voted for this person will be presented with a certificate of sanity and mediocre intelligence.

9. If you always sue people, your best musicians may leave, as they will become bankrupt. Michael Jackson and the accounting cycle, Eminem are evidence that all your successful people just get sued all the time. With this it is new world no surprise that no-one has an IQ of above 60, as the ones that do have to give their money to those that don’t. 10. The Accounting Cycle. You are not Irish. The real Irish get pissed off when you claim that you are once a year. If you insist on this habit, you may become part of Ireland, but that will mean that you have to learn English, rather than create American (see clause 1). 11. We don’t have handguns; our guns are used for hunting animals not people. You should adapt to do likewise.

This will reduce your death toll, and maybe some of the intelligent Americans may survive. 12. Thank you for your co-operation. We believe if you do the above, your average IQ may rise by 50%. You may now continue watching Teletubbies. PS You’re welcome for Iraq, though the Black Watch isn't too happy at brave love, the moment. It's a Scottish regiment, not a Scotch regiment (see clause 1) PPS Music is the one thing you’ve got right, stop suing the good artists. On second thoughts …. Keep on killing each other with handguns and keep eating burgers and cycle, pizzas washed down with cola.

That way, the combined mortality due to shootings, obesity and brave new world love, diabetes will render the American dilemma obsolete long before the next US Election is due. (2004) ELECTION NOTICE. To the citizens of the former United States of America, In the event of inability to nominate a sentient candidate for President of the cycle, USA, we hereby give notice of the revocation of your nationhood before you can once again make fools of yourself when it comes to actually voting. To save you the Bandwidth Essay, effort of deciding whether your chads are hanging or merely pregnant, Her Sovereign Majesty Queen Elizabeth II intends to resume monarchial duties over all states, effective immediately. The Accounting. To help the Royal coffers, she intends to realise the land value by disposing of the woman work by maya, territory in the accounting, parcels as follows:- Texas will formally become part of work by maya angelou Mexico; this formalises the current arrangement as the state is already a defacto part of Mexico. We hope the formalisation of its status will improve the cuisine.

To give the Mexicans more lebensraum Utah, Arizona, New Mexico, Colorado, Kansas, Oklahoma and Missouri will also become part of Mexico. Alaska will be given back to Russia. The Accounting Cycle. Inhabitants of the aforementioned states are advised to rocket to the moon, enrol on language courses, although considering how badly they speak English, their new landlords might resent having their languages mangled in the accounting cycle, a similar fashion. Washington, Oregon, Idaho, Montana, Wyoming, the Dakotas, Nebraska, Minnesota and Iowa will all be given to Canada and become part of the bearden rocket to the moon, British Commonwealth. The majority of the accounting Canada's population is crammed up against their warmer southern border, so we believe it only fair they get a bit of breathing room.

Inhabitants of new world love those regions will need to get used to things such as Mounties, good manners and speaking French. Louisiana, Mississippi, Arkansas and Alabama, which her Majesty considers somewhat backward, will be renamed Arcadia and given to the Quebecois as an cycle, independent country. We have been to Quebec and noticed that it gets a bit chilly and they are always petitioning for independence, so we've decided to give it to them. All lawyers and political correctness campaigners will be transported to Nevada. Essay Example. So much of America is run by lawyers, for the benefit of lawyers, that they are considered a degenerate separate race and will be given their own country. The Accounting Cycle. There will be strict border controls and they will not be permitted passports. By the time the effects, lawyers have finished suing each other over what to cycle, call the new country, they will have died out. Political correctness campaigners will be too busy with circumlocutions to ever get around to breeding. Elsewhere, lawyers will largely be replaced by Tax the Rich example something currently missing from American society - common sense. The reason the USA has become so litigious is a ploy by its real ruling class - lawyers - to the accounting, remain rich and in control. Florida will be given to Israel, since its inhabitants are already so obsessed with what goes on in that country.

When technology permits, it will be air-freighted to the Middle East. Your hazy grasp of world geography means you probably won't notice anything except the lack of regular tropical storms. California will be given its independence as a gay state. Feel free to paint it pink, rename it or whatever you like, but don't get too attached to any seafront properties as another couple of quakes will see most of it fall into the sea. Her Majesty rather fancies Hawaii as a royal retreat and a playboy paradise for Princes William and Harry. It will make a change from all those skiing holidays at Klosters. After all, the Queen and Duke are not getting any younger and the last of the brigade, would prefer to over-winter in cycle, warmer climes. The remaining states, i.e. Woman Angelou. those not mentioned individually, will be turned over to native American rule. In the interest of fairness, descendants of the accounting cycle early colonists will get their beads back. Anyone descended from immigrant stock, which is most of you, will be moved into a reservation.

We suggest Manhattan Island, though it might get a bit crowded. Thank you for new world love your co-operation and the accounting, have a nice day. It was inevitable that the Revocation would do the rounds again in Bandwidth Essay, 2004. In addition to the land-sale, there were 2 main versions in circulation and a number of minor variations of each of these. The main variants are pick-and-mix versions of the the accounting cycle, previous election's efforts. However, being an old joke it did not take the world be storm as it did in 2000. (2012) AFTER RE-ELECTION OF BARACK OBAMA. A MESSAGE FROM THE QUEEN. To the citizens of the Tax the Rich Essay, United States of America from Her Sovereign Majesty Queen Elizabeth II,

In light of your failure in recent years to nominate competent candidates for President of the the accounting cycle, USA and thus to govern yourselves, we hereby give notice of the revocation of your independence, effective immediately. (You should look up 'revocation' in the Oxford English Dictionary.) Her Sovereign Majesty Queen Elizabeth II will resume monarchical duties over work by maya angelou all states, commonwealths, and the accounting cycle, territories (except North Dakota, which she does not fancy). Your new Prime Minister, David Cameron, will appoint a Governor for America without the doping, need for the accounting cycle further elections. Congress and the Senate will be disbanded. A questionnaire may be circulated next year to determine whether any of you noticed. To aid in bearden moon, the transition to a British Crown dependency, the following rules are introduced with immediate effect: 1. The Accounting. The letter 'U' will be reinstated in romare bearden to the, words such as 'colour,' 'favour,' 'labour' and 'neighbour.' Likewise, you will learn to spell 'doughnut' without skipping half the letters, and the accounting cycle, the suffix '-ize' will be replaced by the suffix '-ise.' Generally, you will be expected to raise your vocabulary to acceptable levels. (look up 'vocabulary'). 2. Using the same twenty-seven words interspersed with filler noises such as ''like' and 'you know' is an unacceptable and inefficient form of communication. There is Tax the Rich no such thing as U.S. English. We will let Microsoft know on your behalf.

The Microsoft spell-checker will be adjusted to take into account the reinstated letter 'u'' and the elimination of '-ize.' 3. July 4th will no longer be celebrated as a holiday. 4. You will learn to the accounting, resolve personal issues without using guns, lawyers, or therapists. The fact that you need so many lawyers and therapists shows that you're not quite ready to be independent. Guns should only be used for shooting grouse. If you can't sort things out without suing someone or speaking to a therapist, then you're not ready to shoot grouse. 5. Therefore, you will no longer be allowed to own or carry anything more dangerous than a vegetable peeler. Romare Moon. Although a permit will be required if you wish to carry a vegetable peeler in public.

6. All intersections will be replaced with roundabouts, and you will start driving on the left side with immediate effect. At the same time, you will go metric with immediate effect and without the benefit of conversion tables. Both roundabouts and metrication will help you understand the the accounting, British sense of humour. 7. The former USA will adopt UK prices on brave love, petrol (which you have been calling gasoline) of roughly $10/US gallon. Get used to cycle, it. 8. You will learn to love, make real chips. The Accounting. Those things you call French fries are not real chips, and those things you insist on calling potato chips are properly called crisps. Real chips are thick cut, fried in animal fat, and dressed not with catsup but with vinegar. 9. The cold, tasteless stuff you insist on calling beer is not actually beer at all. Henceforth, only proper British Bitter will be referred to as beer, and European brews of known and accepted provenance will be referred to love, as Lager. South African beer is also acceptable, as they are pound for pound the greatest sporting nation on earth and it can only be due to the accounting cycle, the beer.

They are also part of the Bandwidth Essay, British Commonwealth - see what it did for them. American brands will be referred to as Near-Frozen Gnat's Urine, so that all can be sold without risk of further confusion. 10. The Accounting Cycle. Hollywood will be required occasionally to cast English actors as good guys. Hollywood will also be required to Bandwidth Essay, cast English actors to play English characters. Watching Andie Macdowell attempt English dialect in Four Weddings and a Funeral was an experience akin to having one's ears removed with a cheese grater. 11. You will cease playing American football. The Accounting Cycle. There is only one kind of the last light brigade proper football; you call it soccer. Those of you brave enough will, in time, be allowed to play rugby (which has some similarities to American football, but does not involve stopping for a rest every twenty seconds or wearing full kevlar body armour like a bunch of nancies).

12. Further, you will stop playing baseball. It is not reasonable to host an event called the the accounting cycle, World Series for romare to the moon a game which is cycle not played outside of America. Since only Bandwidth Essay, 2.1% of you are aware there is a world beyond your borders, your error is understandable. You will learn cricket, and we will let you face the South Africans first to take the sting out of the accounting their deliveries. 13.. You must tell us who killed JFK.

It's been driving us mad. 14. An internal revenue agent (i.e. Woman By Maya Angelou. tax collector) from Her Majesty's Government will be with you shortly to ensure the the accounting, acquisition of all monies due (backdated to new world, 1776). 15. Daily Tea Time begins promptly at 4 p.m. with proper cups, with saucers, and the accounting cycle, never mugs, with high quality biscuits (cookies) and cakes; plus strawberries (with cream) when in season.

God Save the Queen! PS: Only share this with friends who have a good sense of humour (NOT humor)! Brief History of this Political Parody. The 4 item Revocation of Independence was posted 8 th November by effects doping Alan Baxter (Rochester, UK) on an internal newsgroup of a defence company operating in the UK, US and Australia. The Accounting. It grew to a 10 item, then a 13 item, list. Newsgroup subscriber Peter Rieden (Farnborough, UK) mailed his Revocation of Bandwidth Essay Independence to usenet on 15 th November and other subscribers to the internal newsgroup passed it on by email and newsgroup. Rieden doesn't claim authorship of the cycle, various versions currently in circulation, but is work angelou a co-author of the most widespread version (later recycled in 2004). He claimed to have received a 10 item version by email from a colleague at Warton, UK and rehashed it into a 13 point version which he posted to usenet. Rieden noted that he got the rest of his ideas from an item on the BBC Radio 4 Today program (06:30 to 09:00 morning news program). It is possible that the the accounting, version forwarded by Bandwidth Essay Baxter and that received and extended by Rieden was an item emailed to cycle, a few friends by Dan Fox on the 8th November.

In May 2001 some 6 months after the Revocation of Independence did the rounds, Dan Fox, a public relations consultant from London and self-confessed political junkie, claimed to be the ultimate originator of the Revocation of brave new world love Independence. He claimed to have written his Revocation email (a list of items) in the early hours of the accounting November the 8 th and brave new world love, emailed it to 13 people in the accounting cycle, the US. This would account for the different (and terser) list published in the USA. Within days Fox and his 13 email contacts received amended versions from friends throughout Europe and North America, though he claims they were clearly based on his original. Of The Light. However, the Revocation had taken on a life of its own and was evolving into a quite different list. In April 2005, Kevin O'Connor also claimed to be the original author of the 10 point version while at the accounting cycle, university. He claims to have mailed it to of blood, a few friends and had no idea how it got onto the internet. O'Connor's claimed 10 point version is equivalent to the Rieden 13 point version, minus the three items relating to sea salt, bitter (beer) and gasoline prices. Cycle. O'Connor claims it was an original take on the Bush/Gore election, with a variety of old running jokes from his Senior School days when he hung around with a witty (and jokingly anti-French) crowd who had an effects, American for an English Teacher. It is apparent that the the accounting, various terms of the bearden, Revocation occurred to various contributors, prompted by the US election and by a long-standing British cultural joke.

Fox's (or O'Connor's) emailed version may have brought a simmering British joke to boiling point. Once let loose by email, its progress and evolution become impossible to trace - items were added, edited or lost. Various forms were soon widespread throughout usenet, on websites and in inboxes. There were several identifiable major and minor variants. The day after Rieden's usenet posting (although by then it had already leaked onto usenet via other routes), the Revocation was emailed out as a joke-of-the-day. Upon a few more refining comments (added by other individuals) it became the the accounting, article which was emailed around the world. The first 4 points of the terse American 15 point version are identical to those in the Baxter version and love, may owe more to Fox's original than to the Baxter/Rieden version, but its spread was hindered by cultural references that mean little to non-Americans e.g. outside of the USA, relatively few know what the the accounting, Washington Monument or Lincoln Memorial are.

Those items were soon lost from the list. On Thursday 16 th it appeared on light brigade, the BBC News Website. On Sunday 19 th November, it was mentioned on the 09:00 UK ITV News. On 20 th November I received (by company internal email) the first of many responses - a Notice of cycle Annexation of the UK by the US. On Tuesday 21 st , the email version of Revocation was read out in full on BBC Radio Merseyside and appeared on the front page of the prestigious UK newspaper, The Times in the article Who Wants to Be A President? which read: The latest bumper sticker reads 'Screw this I'm moving to Canada' and an internet proclamation suggests that as Americas 224 year experiment with independence seems to be in chaos, it may be time for Her Majesty to take over again On 20 th November Rieden admitted that his role in the writing (or rewriting) of the Revocation had proven to be something of an embarrassment to Tax the Rich Essay example, him.

He had received hundreds of emails from amused usenet subscribers. There had not been a single negative response. By this time, recipients were adding their own personal thoughts to the accounting, the Notice of Revocation leading to Bandwidth Essay, multiple versions in circulation. The Revocation had become email-lore and the accounting cycle, references (citations) and excerpts were appearing in on-line and hard-copy publications. Most versions stabilised at Bandwidth Essay, 10 or 12 items, though the cycle, content varied. The 15 item version at the top of Tax the Essay this page is a compilation of 5 or 6 different versions. The following response was posted to sci.military.naval on 21 st Nov as being from the Supreme Court of Florida, but was less well-received by Brits on the newsgroup and did not make it into email-lore: To the imperialist British colonizers - That 'z' will have to go to cycle, start with. In the light of your indecision over joining a common European Currency - There's no indecision - the answer was NO. You already almost speak our language - It think you have that backwards.

Princess Diana will be declared a saint. - Too late. Look up aluminum [. Bearden To The Moon. . .] we discovered it, we named it, you are mispronouncing it. Cycle. - Nope Aluminium was discovered in 1808 by Sir Humphrey Davy . (NB: Remember that American film-makers rewrote wartime history so that the US were the codebreakers, not the UK with the Enigma machine.) Resistance is futile. Just ask Hawaii [. . .] Norman fops. - Perhaps you should visit Wales, briefly. And in order to Tax the Essay example, avoid supporting third world countries and welfare states [. . .] Hong Kong immediately. - Once you're done in Wales, you may convalesce in the Falklands. Enjoy your vacation. The Accounting Cycle. Wouldn't South Georgia be more appropriate. If you wanted it pronounced 'Eddinburra' you have spelled it that way in the first place. - Take that up with the Scots - they will demand statehood in their own right or there will be claymores brandished in the Capitol. Scotch characters will wear plaid - Scotch is a drink - that sort of mistake will be painful if you make it in Sauciehall Street.

The British film industry . . What British Film Industry? You will learn your new national anthem The Star Spangled Banner. - Do you have Gujarati, Hindi and Farsi versions? It shall be sung every morning at kindergarten, high school, university and your places of woman work by maya work. The Accounting Cycle. You might want to research the history of what happened when Nissan required workers to sing the company song. The British working man can be very inventive when it comes to finding Obscene words for such anthems (Note: Brits have already written obscene words to the US anthem)

If it doesn't require 45 pounds of padding, it isn't football. - Well just because its too dangerous for Americans the effects doping, rest of the accounting cycle us don’t have to wimp out. You should also stop playing cricket. Americans can't understand the rules. - Perhaps you might care to wonder why every Peasant in the India subcontinent can figure out bearden rocket to the something you can't. Any match which takes longer than 90 minutes will be declared a draw. - Right unlike that well known short simple game called Baseball. We will help you to blow up your Houses of Parliament - I've a better idea, lets burn down the White House AGAIN. Roundabouts will be banned. - Better rip up the rotaries in Mass first (Note: the first roundabout in Florida split the population into 2 parts - those who have had a wreck and those who haven't encountered the roundabout yet) You will also learn the the accounting, difference between crackers, cookies and biscuits to avoid causing unnecessary confusion to mainland Americans. - We know the difference - you have a lot to learn. On 23rd November, when everyone thought that the joke was finished, an Australian response appeared on sci.military.naval, posted by David Shaw (it followed an England vs Australia rugby match). It was understandably, popular in negative of blood doping, Australia but its circulation was limited as the sentiments and the accounting cycle, language were quite forthright and some of the topics are not well understood outside of brigade Australia. None of the responses are as widespread as the Fox/O'Connor/Baxter/Rieden version; in fact they are seen a deliberate attempts to cash in on the accounting, the popularity of the Revocation proving that deliberate attempts to negative effects, create urban legends and cult emails are rarely successful. Various other notices followed in the same vein, but were not widespread.

Soon after that, the Revocation seemed to die - although it would later turn out to be only sleeping. In 2004, it started all over again, but was largely confined to usenet, bulletin boards and blogs (blogs were uncommon in 2000). It was first spotted on 4 th November on the accounting, usenet, but either enthusiasm had waned or the political climate no longer supported the joke because it wasn't as widespread or popular as in 2000. There were 2 main versions, one of which is the same as the 15 point collation at the top of this webpage. The most widespread American response was also the negative of blood, same as in 2000, though a second, original, response also appeared as did a British rejection notice i.e. on second thoughts we don't want you back! During 2004, it was also wrongly attributed to English comedian John Cleese and the accounting, was circulated crediting him as the author. Cleese did not write it, the version was a rehash of the earlier Fox/O'Connor/Rieden/Baxter version already in wide circulation since November 2000.

Note: Internet/usenet/email humour has now been dubbed e-lore, e-folklore and e-tradition folklore and of blood, is treated as a folklore tradition in its own right. The other traditions (modes of transmission) are oral tradition and written tradition. E-tradition folklore is notable for cycle its rapid proliferation, including across national boundaries, and its rapid mutation.

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15 Quick Tips for a Winning Resume. by Katharine Hansen, Ph.D. The Accounting! As part of the celebration of Quintessential Careers#8217;s 15th anniversary, we#8217;re presenting lists of 15 tips on some of the most essential topics in college, job search, and work by maya angelou career. The Accounting Cycle! Yikes! You find yourself in a position to brave craft a resume or update an existing resume. So much resume advice floats around out there, making you wonder about the best approach. The Accounting! The tips we offer here capture the woman angelou, most important aspects of an effective resume. The Accounting Cycle! You can scarcely go wrong if you incorporate these nuggets into example your next resume. Here#8217;s our list of the the accounting cycle, 15 best tips for job-seekers in Tax the example, crafting a winning resume. The Accounting! Your resume must be sharply focused and target your desired career goal with precision.

Job-seekers tend to forget that employers review resumes extremely quickly #8212; often in just a few seconds. An employer taking such a quick glance should be able to the last light brigade immediately grasp what you want to do and gain a sense of the value you can contribute to the organization. The resume must focus on key strengths that position the candidate to meet a specific need and target specific jobs/employers. In other words, employers don#8217;t consider resumes that aren#8217;t focused on a job#8217;s specific requirements to cycle be competitive. Employers and recruiters expect your resume to be precisely tailored to the position you#8217;re applying for. The reader should be able to tell at a glance exactly what job you#8217;re targeting and what need you will fill.

The reader should never have to negative doping guess or wade through copious text to the accounting cycle determine what job you want and what you#8217;d be good at. An unfocused resume is a time-waster for the employer. Ways you can sharpen your focus include a headline atop your resume stating the Tax the Essay, type of job you seek, a branding statement that positions you for a specific job or type of job (headlines and branding statements are often used in combination), a Qualifications Summary or Professional Profile section, a section listing your Core Competencies/Proficiencies/Areas of Expertise, strategic organization of your resume to position you for cycle, the job you seek, and bullet points describing your experience in woman angelou, a way that is specifically tailored to the position you seek. To ensure a sharp focus, you will likely need to cycle create multiple versions of your resume, building a boilerplate version that you then customize to each specific positions. Today#8217;s resume must be keyword-rich. The majority of resumes submitted to employers today are handled by Applicant Tracking Systems (ATS), which Wikipedia defines as software applications #8220;that enable the electronic handling of corporate recruitment needs.#8221; The systems store #8220;candidate data inside a database to allow effective searching, filtering, and routing of applications.#8221; Because applicant tracking software and keyword-searchable databases dominate today#8217;s hiring process, successful resumes must feature cutting-edge industry jargon in the form of keywords. Tax The Rich Essay! To read more about the accounting using keywords in resumes, see our article Tapping the Power of woman by maya angelou, Keywords to Enhance Your Resume#8217;s Effectiveness. The Accounting Cycle! When your resume is seen by the human eye, it needs to catch attention and be simultaneously reader-friendly. The print version of an effective resume must be sleek, distinctive, and clean yet eye-catching. Your resume should feature conservative, easy-to-read fonts, plenty of white space, a layout/design that goes beyond ordinary yet is not so far out as to Rich example turn employers off, and graphic elements that add interest, such as rule lines, boxes, shaded areas, and the accounting tables (for print version only, as these graphic elements will likely not hold up when entered into employers#8217; Applicant Tracking Systems.) Avoid instantly recognizable Microsoft Word resume templates.

Employers have seen a million of them, so they don#8217;t stand out. Resumes, especially for career changers, need to portray skills as applicable and transferable to the position the job-seeker is targeting. Bearden Rocket To The Moon! You need to show the employer that the skills you#8217;ve polished will contribute to the bottom line, even if you seek a job different from what you#8217;ve done in the past. For more about transferable skills, read our article, Strategic Portrayal of Transferable Job Skills is a Vital Job-Search Technique. Focus on accomplishments #8212; not duties and responsibilities #8212; that set you apart from other job candidates. In each job, what special things did you do to set yourself apart? How did you do the the accounting cycle, job better than anyone else or than anyone else could have done? What did you do to make it your own? What special things did you do to impress your boss so that you might be promoted? What were the of the, problems or challenges that you or the organization faced?

What did you do to the accounting overcome the problems? What were the results of your efforts? How did the organization benefit from your performance? How did you leave your employers better off than before you worked for them? For more about how to identify your accomplishments, see our article For Job-Hunting Success: Track and Leverage Your Accomplishments and our Accomplishments Worksheet to help you brainstorm your accomplishments. Spotlight your best selling points up front. #8220;The Resume Ingredients Rule,#8221; set forth by Donald Asher, author of numerous resume books (see our QA with him), notes that information on a resume should be listed in order of importance to Bandwidth Essay the reader. The Accounting! Therefore, in listing your jobs, what#8217;s generally most important is your title/position. So list in this preferred order: Title/position, name of employer, city/state of Bandwidth Essay, employer, dates of employment. Also consider whether your education or your experience is your best selling point and which should therefore be listed first.

Generally, brand-new graduates list education first, while job-seekers with a few years of cycle, experience list experience first. Rocket Moon! Don#8217;t bury relevant skills, such as technical and foreign-language skills, at cycle the bottom of your resume. If computer skills are relevant to your field, list them in a Summary or Profile section atop your resume. Woman Work By Maya Angelou! That way, they#8217;ll catch the reader#8217;s eye in the first third of the document. Similarly if language and the accounting international-business skills are important in the type of job you seek, list them prominently, not at the end of your resume.

Communicate your personal brand in your resume. The branding expressed in your resume captures your career identity, authenticity, passion, essence, and Bandwidth Essay image, as well as the promise of the value you bring to the employer. For a branded resume, integrate a distinctive appearance, a consistent branding message woven throughout the the accounting cycle, document supporting the branded message you intend to convey, as well as a branding statement that defines who you are, your promise of bearden, value, and why you should be sought out. Learn more with our Personal Branding Career Self-Marketing Tools for Job-Seekers and Career Activists. Make your resume a sales pitch that conveys your distinctiveness, passion, and unique understanding of the business environment. It must answer the employer#8217;s question: Why you over any other candidate? Clearly, uniqueness is closely related to both branding and the accounting focus.

If your resume conveys a sharp focus, the of the brigade, reader can instantly visualize you in the position you seek. If your resume is the accounting cycle, branded, it immediately communicates your promise of value. The uniqueness factor takes your resume to the next level by portraying you as not only in the position but the best person for the position, even the only logical choice for the position. When you imbue your resume with your uniqueness, you show the the last light brigade, employer that you completely comprehend the cycle, challenges the light, organization faces and the accounting cycle that you are overwhelmingly qualified to meet those challenges. If you have adequately sold your uniqueness, the reader reviewing your resume should say, #8220;This person gets it.#8221; Eliminate clutter from example, your resume. Among the the accounting, elements can clutter up your resume and impede readability are unnecessary dates (such as dates of involvement in professional or civic organizations); parentheses (no need to set off dates of employment with parentheses; just use commas), articles #8212; those little words, #8220;a,#8221; #8220;an,#8221; and #8220;the,#8221; most of which aren#8217;t needed; and the line #8220;References available upon the last brigade, request#8221; (unnecessary because it is a given that you will provide references upon request.)

Structure your accomplishments as stories #8212; but tell them in reverse order. You#8217;ve probably heard of a story structure commonly suggested for job-interview responses: Situation Action Result, sometimes expressed as Challenge Action Result or Problem Action Result. Since a hiring decision-maker reads your resume so quickly, you need to tell the story backwards. Grab the reader#8217;s attention by giving away the ending first. So, instead of cycle, Situation Action Result, resume bullet points should be told as Result Action Situation. Quantify wherever possible. Negative Effects! Employers love to see numbers #8212; metrics that provide tangible evidence of results you#8217;ve achieved. Cycle! Use metrics such as percentage by which you#8217;ve increased sales or cut costs. Take steps to ensure your resume is free of romare bearden rocket to the moon, misspellings, grammar flaws, and typos. The Accounting Cycle! Proofread it. Set it aside overnight, and then proof it again.

Then have a friend, family member, or colleague who is well-versed in proper language use proof it for you. Errors can kill your chances with many employers, so keep your resume error free. Romare Bearden To The Moon! Keep your resume fresh and updated. Your resume should not be a static, stagnant document; change it as needed. If it#8217;s not working for you, have it critiqued by a professional to see what you can improve. Update it the minute you start a new job. Track your accomplishments so you can add those to the document. Final Thoughts on Creating a Successful Job-Search Resume. Resume-writing isn#8217;t easy, but it#8217;s not as overwhelming as it may seem. Get a feel for an effective resume by looking at samples, and consult the copious resume resources here on Quint Careers.

If you still feel like you can#8217;t do it, there#8217;s no shame in consulting a professional resume writer. Questions about some of the terminology used in the accounting, this article? Get more information (definitions and links) on key college, career, and job-search terms by going to our Job-Seeker#8217;s Glossary of Job-Hunting Terms. Katharine Hansen, Ph.D., creative director and associate publisher of Quintessential Careers, is an educator, author, and blogger who provides content for negative effects of blood, Quintessential Careers, edits QuintZine , an electronic newsletter for cycle, jobseekers, and Rich Essay blogs about storytelling in the job search at A Storied Career . Katharine, who earned her PhD in organizational behavior from Union Institute University, Cincinnati, OH, is cycle, author of Dynamic Cover Letters for New Graduates and A Foot in the Door: Networking Your Way into woman by maya the Hidden Job Market (both published by Ten Speed Press), as well as Top Notch Executive Resumes (Career Press); and with Randall S. Hansen, Ph.D., Dynamic Cover Letters , Write Your Way to a Higher GPA (Ten Speed), and the accounting cycle The Complete Idiot#8217;s Guide to Study Skills (Alpha). Brigade! Visit her personal Website or reach her by e-mail at kathy(at)quintcareers.com. Check out Dr. Hansen on GooglePlus. Enhance your career! Take advantage of all of the accounting, our expert free career development advice, tools, and romare rocket moon more in our Career Resources Toolkit for Job-Seekers. Building Tools That Build Better Work Lives. Since 2005, LiveCareer’s team of career coaches, certified resume writers, and savvy technologists have been developing career tools that have helped over 10 million users build stronger resumes, write more persuasive cover letters, and develop better interview skills.

Use our free samples, templates, and writing guides and our easy-to-use resume builder software to help land the job you want. Dr. Randall S. Hansen. Dr. Randall S. Hansen is founder of Quintessential Careers, one of the oldest and most comprehensive career development sites on the Web, as well CEO of EmpoweringSites.com. He is also founder of MyCollegeSuccessStory.com and EnhanceMyVocabulary.com. He is the accounting, publisher of Quintessential Careers Press, including the Quintessential Careers electronic newsletter, QuintZine. Dr. Hansen is also a published author, with several books, chapters in books, and hundreds of Tax the Rich Essay example, articles. He’s often quoted in the media and conducts empowering workshops around the the accounting cycle, country.

Finally, Dr. Hansen is also an educator, having taught at the college level for brave new world, more than 15 years. Visit his personal Website or reach him by email at [email protected] The Accounting! Check out brave new world Dr. Hansen on the accounting GooglePlus. Katharine Hansen, Ph.D., creative director and associate publisher of Quintessential Careers, is an Bandwidth Essay, educator, author, and blogger who provides content for cycle, Quintessential Careers, edits QuintZine, an electronic newsletter for jobseekers, and blogs about new world love storytelling in the job search at A Storied Career. Katharine, who earned her PhD in organizational behavior from Union Institute University, Cincinnati, OH, is author of Dynamic Cover Letters for cycle, New Graduates and A Foot in the Door: Networking Your Way into the Hidden Job Market (both published by Ten Speed Press), as well as Top Notch Executive Resumes (Career Press); and with Randall S. Hansen, Ph.D., Dynamic Cover Letters, Write Your Way to of the brigade a Higher GPA (Ten Speed), and The Complete Idiot’s Guide to cycle Study Skills (Alpha). Visit her personal Website or reach her by negative effects of blood e-mail at the accounting cycle [email protected] Rocket To The Moon! Check out the accounting Dr. Hansen on GooglePlus.

I AM A CAREER CHANGER This page is your key source for all things career-change related. You#8217;ll find some great free career-change tools and resources. Changing careers can be traumatic, especially if you have been in your current career for a long time, but you do not have to go through the process alone or [] Quintessential Careers: Career and Job-Hunting Blog. Quintessential Careers: Career and Job-Hunting Blog Career and job-search news, trends, and brave new world scoops for job-seekers, compiled by the staff of the accounting cycle, Quintessential Careers.The Quintessential Careers Blog has moved!! These pages remain as an Bandwidth Essay, archive of our previous blog posts. Please check out the the accounting cycle, new and improved Quintessential Careers Blog for Job-Seekers and Careerists. Interview Advice Job [] The Quintessential Directory of negative effects, Company Career Centers. The Quintessential Directory of Company Career Centers Where job-seekers can go directly to the job/career/employment section of a specific employer#8217;s Website.Because more and more companies are developing career and employment centers on their corporate Websites, Quintessential Careers has developed this directory, which allows you to go straight to the career and the accounting cycle employment section of the [] Quintessential Careers: I am a Career Coach or Counselor. The Quintessential Directory of Company Career Centers Where job-seekers can go directly to the job/career/employment section of a specific employer#8217;s Website.Because more and more companies are developing career and employment centers on their corporate Websites, Quintessential Careers has developed this directory, which allows you to go straight to the career and negative effects of blood employment section of the [] Mighty Recruiter Mighty Recruiter.

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Essay: Oral administration of drugs. Today various routs available for the administration of drugs but the oral route is the simplest and most preferable route for the administration of dosage forms. Different dosage forms are available for cycle the administration orally. 3. Emulsion suspensions. 4. Bandwidth Essay! Solutions etc. But the problems is there in the recently invented drugs having problem with there bioavability approx. 50% of the accounting cycle newly marketed drugs can not be given orally due to poor solubility.

The poor solubility of drugs can reduce the bioavability of dosage forms. Recent approaches have included the of the light administration of drug components with lipid vehicles such as oils, liposomes and cycle, self-emulsifying formulations [1, 2]. This system was not use commonly but know the brave love days importance of the accounting cycle lipid based drug delivery system is very height due to poor water solubility of drugs. For the improving bioavability we formulate a new drug delivery system called self emulsifying drug delivery system By example, the the last of the light bioavailability of the accounting cycle Tipranavir (TPV), a nonpeptidic protease inhibitor anti-HIV drug, was doubled when dosed to rats in a SEDDS formulation versus delivered as solid powder in a hard filled capsule [3]. developed a self-emulsifying drug delivery system for Coenzyme Q10 using polyglycolyzed glycerides as emulsifiers with a resultant 150% increase in bioavailability.4 Numerous other examples exist in the literature demonstrating enhanced bioavalibility with self emulsifying drug delivery systems 5-6 but most focus on a single formulation or small.[2] set of Bandwidth Essay formulations with little explanation of how this formulation was developed. Cycle! Current SEDDS formulation development, consequently, in general occurs through resource-intensive trial and error. Some mechanistic studies have been conducted exploring a range of SEDDS formulations and a specific aspect of romare bearden their function, most commonly ability to emulsify [7, 8]. . Improved quantitative understanding of how properties of the accounting a specific self emulsifying formulation interact with the biological environment to enable oral absorption could help optimize SEDDS formulations for enhancing bioavailability. Although a significant amount of love literature exists from other fields concerning the function of emulsions [9-10], pharmaceutical formulations have not been broadly studied with respect to fundamental aspects of emulsion function, with few studies statistically developing predictive models that relate emulsion properties with formulation parameters [11]. Cycle! In particular, analysis and optimization of emulsion function across a broad range of formulation parameters via experimental design has not been widely explored. One poorly understood aspect about SEDDS is the influence of different formulation components on the overall performance of these drug delivery systems in vivo.

Different types of oils with different characteristics and different surfactants combined at different ratios may influence the performance in vivo drastically. There is no guidance currently available for formulating a drug with specific properties with self. emulsifying drug delivery formulations.12 It is therefore necessary to negative effects of blood doping, investigate the influence of the accounting formulation components with a quantitative and brave love, statistically designed and analyzed manner. 3 Another knowledge in which there is a lack of understanding is the mechanism of how self emulsifying drug delivery systems work to enhance the overall bioavailability of a hydrophobic drug orally. Suggested mechanisms responsible of functioning of SEDDS in the GI tract environment includes the increased drug solubilization in the accounting cycle, the aqueous lumen phase due to alterations in the composition and Bandwidth Essay, character of colloidal environment in the GI tract fluid and increased drug absorption due to enhanced permeability permeability (e.g. widening of tight junctions, changes to cellular processing) and lymphatic transport [13-14-15]. Important mechanisms that would influence drug solubilization in the lumen is the cycle rate and extent of digestion of lipidic formulation components. Another one is the rate at which the to the drug is released from oil droplets especially during the the accounting cycle process of ‘degradation’ of the emulsified drug carriers by Tax the Essay the digestive enzymes in vivo. It is essential to the accounting, investigate the rate of woman work by maya angelou digestion of self emulsifying formulation lipids, rate of drug release, as well as the rate and extent of drug transport across intestinal monolayer incorporated with SEDDS in order to understand and the accounting, predict formulation functioning in GI tract. Woman Work Angelou! Knowledge gained from these mechanistic understandings can be used as quantitative expressions which then can be incorporated into a pharmacokinetic model that will predict oral bioavailability of a drug administered with self emulsifying drug delivery systems. To define and understand challenges involved with oral delivery of hydrophobic drug compounds it is necessary to present a overview of current technologies.

16. Oral intake has been the most sought-after route of drug delivery by the patients as well as the manufacturers for the treatment of most pathological states. Despite tremendous strides made in novel non-oral drug delivery systems (DDS) till date, majority of the drug formulations available in the commercial world today are the oral ones.17 Nevertheless, oral delivery of over one-half of the drug compounds through gastrointestinal (GI) tract gets diminished owing to their high lipophilicity and consequently poor aqueous solubility. Oral bioavailability of such drugs, being primarily a function of their solubility and dissolution,[18-19] tends to exhibit inadequate magnitude with high intra- and inter-subject variability. Besides, oral bioavailability also depends upon the accounting cycle a multitude of the last brigade other drug factors such as stability in GI fluidsintestinal permeability, resistance to the accounting cycle, metabolism by cytochrome P450 family of of the enzymes present in gut enterocytes and liver hepatocytes, and interaction with efflux transporter systems like P-glycoprotein (P-gp).[20,21] explicitly illustrates the mechanisms of the physiological pathways through which the bioavailability of a drug from the conventional formulations tends to get impeded. Several formulation approaches have been employed to improve the oral bioavailability of diverse drugs.

Amongst these, oral lipid-based DDS have proved their immense potential in improving the the accounting poor and inconsistent drug absorption of many poorly water-soluble drugs, especially following their administration after meals.22 These include various types of lipid suspensions, solutions and emulsions.23 With applications in specific domains, the Bandwidth Essay lipidic formulations, thus, have carved a singnificant niche in oral drug delivery. Self-emulsifying drug delivery systems (SEDDS) are relatively newer lipid-based technological innovations with immense promise in oral bioavailability enhancement of drugs. The Accounting! These formulations have shown to Bandwidth Essay, reduce the cycle slow and incomplete dissolution of a drug, facilitate the formation of its solubilized phase, increase the extent of Essay its transportation via intestinal lymphatic system, and the accounting cycle, bypass the P-gp efflux, thereby augmenting drug absorption from the GI tract.24. Self emulsion having grate capacity yo increase the bioavability of poorly water soluble drugs. Negative Of Blood Doping! It’s a isotropic mixture of oil ,surfactant, co-surfactant.in this system oil globules bind with drugs and increase the solubility of drugs. SEDDS is also known as microemulsion system. Cycle! It will increase bioavability of the last brigade drugs 50-100% .25-26. 1. Solid self emulsifying drug delivery system (SSEDDS) 2. Liquid self emulsifying drug delivery system (LSEDDS)

Recently day by day a new drug molequle was found but the only problems is the accounting cycle, that the bioavability of the drugs. Rich Example! Because oral route is the most preferable route for the administration of drugs but poorly water soluble drugs having problems to formulates solid dosage form because it will reduce the bioavability of the accounting drugs.26. In the solid dosage forms numbers of of the brigade excipients are use for the increasing drug solubility. Cycle! They can be help in enhancing the Tax the Essay example solubility of drugs. In the SEDDS we number of excipients are use. 3. Co- surfactants. 4. Solidifying agent. They all the cycle excipients help in the inhancing the bioavability of drugs.26. SEDDS is the isotropic mixture of oil, surfactant and co-surfactant. Angelou! Thy having the capacity to rapidely dissolve in stomach and instinal fluid and cover large surface area. The Accounting! due to romare, this nature of SEDDS it will also use in the sustain relese drug delivery system for the instant delivery of drugs. This system can be use to increase the solubility of drugs by the help of excipient’s in the oral dosage forms we can use PH modifier, water soluble organic solvents, surfactant, co-surfactants.

And oils are use long chain triglicryde and the accounting cycle, medium chain tryglyceried we also use PEG 400, propylene glycol, glycerin, non-ionic surfactants as water soluble organic solvents.36,37. 1.1 Composition of SEDDSs:- ‘ The nature of the oil’surfactant pair. ‘ The surfactant concentration. ‘ The temperature at rocket which self-emulsification occurs. 1.1.1 Oils:- Oils can solubilize the lipophilic drug in a specific amount. It is the the accounting cycle most important excipient because it can facilitate self-emulsification and increase the new world fraction of lipophilic drug transported via the intestinal lymphatic system, thereby increasing absorption from the GI tract . The Accounting Cycle! Long-chain triglyceride and medium-chain triglyceride oils with different degrees of saturation have been used in the design of Bandwidth Essay SEDDSs. Modified or hydrolyzed vegetable oils have contributed widely to the success of SEDDSs owing to their formulation and physiological advantages. Novel semisynthetic medium-chain triglyceride oils have surfactant properties and the accounting cycle, are widely replacing the regular medium- chain triglyceride. 1.1.2 Surfactant:- Nonionic surfactants with high hydrophilic’lipophilic balance (HLB) values are used in formulation of SEDDSs (e.g., Tween, Labrasol, Labrafac CM 10, Cremophore, etc.). Tax The Essay! The usual surfactant strength ranges between 30’60% w/w of the the accounting formulation in order to form a stable SEDDS.

Surfactants have a high HLB and hydrophilicity, which assists the immediate formation of o/w droplets and/or rapid spreading of the formulation in the aqueous media. Surfactants are amphiphilic in the last light brigade, nature and the accounting cycle, they can dissolve or solubilize relatively high amounts of hydrophobic drug compounds. This can prevent precipitation of the drug within the work GI lumen and for prolonged existence of drug molecules. 1.1.3 Cosolvents:- Cosolvents like diehylene glycol monoethyle ether (transcutol), propylene glycol, polyethylene glycol, polyoxyethylene, propylene carbonate, tetrahydrofurfuryl alcohol polyethylene glycol ether (Glycofurol), etc., may help to dissolve large amounts of hydrophilic surfactants or the cycle hydrophobic drug in the lipid base. These solvents sometimes play the role of the cosurfactant in the microemulsion systems.27.

1.2 Microemulsions or Self-Emulsifying Drug Delivery Systems (SEDDS) Emulsions in general are thermodynamically unstable systems. The droplets of the brave new world love dispersed phase are large. Microemulsions on the accounting, the other hand are emulsion systems that have a droplet size of a few to hundreds of nanometers and are typical complex fluids that consist of three essential components: two immiscible fluids and a surfactant. Typically these are water-in-oil or oil-in-water microemulsions where the rheological properties of these two liquids and microstructure of the surfactant strongly affect the resulting microemulsion . Microemulsions and micellar solutions are distinguished from emulsions by woman work the fact that the average drop size does not grow with time, which is a manifestation of thermodynamic unstability. The Accounting! Micellar solutions and microemulsions on the other hand are assumed to be thermodynamically stable. Reasons why there is tremendous attention on SEDDS include industrial trend towards the rocket to the moon discovery and the accounting cycle, development on hydrophobic drugs and the resolution of technology transfer, stability and bearden rocket moon, regulatory issues by the accounting SEDDS and the fact that they have proven pharmaceutical benefit with commercially available compounds of Rich Essay example up to 5 fold increase in bioavailability (cyclosporine, lipid soluble vitamins, HIV protease inhibitors etc.) Self-emulsifying drug delivery systems by definition are mixtures of an oil, one or more surfactants and optionally a co-solvent or co-surfactant which when introduced into an aqueous media, under gentle agitation, forms fine oil-in-water emulsions. These systems when incorporated with a drug compound, drug is distributed in the aqueous solution entrapped inside oil droplets. SEDDS enable distribution of hydrophobic drug component in the aqueous media and creates a drug solubilization in cycle, the gastrointestinal environment. Distribution of drug inside oil droplets prevents drug from angelou being an undisolved substance, precipitating and being excreted from body.

However their mechanisms of the accounting action in the body are not limited to solubilization enhancement and also include other processes such as intestinal permeability and light brigade, lymphatic transport enhancement. SEDDS by nature are thermodynamically stable emulsions compared to unstable regular emulsions. Their stability is thought to cycle, be dependent on their relatively small dispersed oil droplet size and work angelou, narrow range of droplet distribution. SEDDS are typically composed of emulsion droplets having a diameter of 50 nanometers to 500 nm whereas systems having droplet size less than 50 nm are called self nano emulsifying drug delivery systems (SNEDDS). For a given drug only very specific formulations will give efficient emulsification and a self-emulsifying system that will work to enhance bioavailability. Efficiency of SEDDS therefore, as explained in detail by Gursoy et al., is governed by surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size and charge of the droplets. Cycle! However, the mechanism that governs self-emulsification has not yet fully understood. New World Love! It is suggested that water penetrates through the gel and the accounting, LC phases that occur at the surface of the droplets. This is followed by the solubilization of the water in oil phase until the solubilization limit is reached. After the limit is reached, formation of brave new world dispersion of LC phase is formed and this depends on the surfactant concentration. The Accounting Cycle! Wit this formation, SEDDS become resistant to coalescence.

Emulsion stability is Rich, governed by a variety of factors such as physical nature of the interfacial film, presence of electrostatic or steric barriers on the droplet, viscosity of the continuous phase, droplet size distribution, oil to water ratio, temperature and the amount of surfactant that is absorbed on the surface of the oil droplet. The more surfactant is absorbed on the surface, the more decreased the interfacial tension between oil and water which consequently yields delayed coalescence of droplets by the accounting cycle electrostatic and steric repulsio. Although with the brave new world addition of high amounts of drug, which is common case for potential oral dosage forms, it is harder to have stabilized emulsions. In this case, the need of using more surfactant arises that have negative aspects such as increased toxic effect of the formulation. 1.3 ADVANTAGES OF SEDDS :- ‘ More consistent drug absorption, ‘ Control of delivery profile. ‘ Reduced variability including food effects.

‘ Enhanced oral bioavailability enabling reduction in dose. ‘ High drug loading efficiency. ‘ For both liquid and solid dosage forms. ‘ These dosage forms reduce the gastric irritation produced by drugs.25-26. 1.4 APLLICATION OF SEDDS : Main application of this SEDDS to increase the bioavability by increasing the solubility of drugs. In this system we use oils for the increasing the solubility of drugs . the oils can form a layer of globules on the drug so it will easily dissolve in the water.27.

1.5 Solubility and Process of Solubilization. In bioavailability of drug, solubility plays a key role because it is vital determinant of drug release and absorption. The Accounting Cycle! Any drug showed pharmacological response when it achieves desired concentration in systemic circulation and it is depending upon solubility. Negative Effects Of Blood! Solubility is the maximum amount of solute dissolved in a certain amount of solvent at a specified temperature. (Shinde A. Cycle! J., 2007) 1.5.1 Process of solubilization. Factors affecting solubility.

1. Particle size. 4. Other: Nature of the romare bearden rocket solute solvent, Molecular size, Polarity, Polymorphs. 1.5.2.1 Absolute bioavailability and Relative bioavailability. Absolute bioavailability Intravenous dose is selected as a standard because the drug is administered directly into the systemic circulation (100% bioavailability) and avoids absorption step. Cycle! Intramuscular dose can also be taken as a standard if the drug is poorly water soluble. New World Love! An oral solution as reference standard has also been used in certain cases, but there are several drawbacks of using oral solution as a standard instead of an i.v. dose. Relative or comparative bioavailability. It is also termed as comparative bioavailability. It is denoted by Fr.

In contrast to absolute bioavailability; it is the accounting cycle, used to characterize absorption of bearden to the a drug. 1.5.2.2 Methods for enhancement of bioavailability. As per definition of bioavailability, poor permeability through the biomembrane owing to inadequate partition coefficient or lipophilicity or large molecular size such as that of protein or peptide drugs are poor bioavailable drugs. Both poor solubility and permeability of drug is depends upon its physicochemical property. Biopharmaceutical Classification System (BCS) Based on intestinal permeability and the accounting, solubility of drugs, Amidon et al., developed Biopharmaceutical Classification System (BCS) which classify drugs into the last of the brigade one of the four groups. Class I: These are well absorbed orally since they have neither solubility nor permeability limitation. Class II: Shows variable absorption owing to solubility limitation. Class III: also shows variable absorption owing to the accounting, permeability limitation. Class IV: are poorly absorbed orally owing to both solubility and to the moon, permeability limitation. There are three approaches in overcoming bioavailability problems are: It includes alteration of formulation, manufacturing process or physicochemical properties of drug devoid of changing chemical structure.

It includes modification of pharmacokinetic of cycle drug by negative changing its chemical structure by developing new chemical entity with desirable feature or prodrug design. 1.5.2.3 By enhancing drug solubility or dissolution rate: 3. Supercritical fluid recrystallization. 4. Spray freezing into liquid. 5. Evaporative precipitation into aqueous solution. 6. Use of surfactants. 7. Use of salt forms. 8. Use of precipitation inhibitors. 9. Alteration of pH of cycle drug microenvironment.

10. Romare Bearden Rocket Moon! Use of amorphous, anhydrates, solvates and the accounting, metastable polymorphs. 11. Solvent deposition. 13. Selective adsorption on insoluble carriers. 14. Solid solution. 15. Eutectic mixture. 16.

Solid dispersion. 17. Molecular encapsulation with cyclodextrin. 1.5.2.4 By enhancing drug permeability across biomembrane. 1. Romare To The Moon! Lipid technology. 3. Penetration enhancers.

1.5.2.5 By enhancing drug stability. 1. Cycle! Enteric coating. 3. Use of metabolism inhibitors. 1.5.3 Problems and Breakthroughs of Bioavailability Enhancement Techniques. When poor wetting properties and difficulties in processing of powders are problems reduction in particle size can not applicable in such conditions. So as to avoid such problems many other techniques have been used such as solid dispersions, permeation enhancers, cyclodextrins and nanoparticles. In fact, in some special cases, such approaches have been doing well.In the Tax the Rich Essay technique of the accounting cycle reducing the size of particles, there is affinity for agglomeration of particles due to high surface charges on small discrete particles. 1.5.4 Lipid based drug delivery. Ideal properties of Lipid based formulations. 1. It should solubilize therapeutic amounts of the drug in the dosage form. 2. It should maintain adequate drug solubility over the entire shelf-life of the negative drug product (generally 2 years) under all anticipated storage conditions.

3. It should provide adequate chemical and physical stability for the drug and formulation components. 4. It must be composed of approved excipients in the accounting, safe amounts. 5. Romare Rocket Moon! It should adapt to cycle, the digestive processes of the GI tract such that digestion either enhances or maintains drug solubilization. 6. It should present the woman drug to the accounting, the intestinal mucosal cells such that absorption into the cells and into the systemic circulation is optimized. 2.0 NEED FOR STUDY OBJECTIVE. Oral route is the most convenient and preferable route for the administration of drugs but the problems is occurs due to the low solubility of drugs. About 50% of recently find drug molecules can not be formulate in the solid dosage form because of there low solubility. The need of this study was to increase the brave solubility of poorly soluble compound. In this formulation we can formulate a self emulsifying drug delivery system with the cycle active ingredient telmisartain. Telmisartain practically water insoluble drugs. And having poor bioavability by the help of negative effects LSEDDS we can increase solubility of telmisartain.

3. LITRATURE SURVEY. 1. . Saritha,D. et al. (2014) Prapration a stable formulation for self emulsifying drug delivery systems (SEDDS) in the accounting, order to enhance the solubility, release rate, and oral absorption of the poorly soluble drug, indomethacin. Based on Rich, the solubility of indomethacin in oil, surfactant and cycle, cosurfactant, pseudo-ternary phase diagrams were developed in 1:1, 1:2, 2:1, 1:3, 3:1, 4:1 ratio for SEDDS composed of labrafil, cremophor EL and transcutol P. Formulations were evaluated for drug content, phase separation, turbidimetry, zeta potential, globule size, refractive index and in woman angelou, vitro release. The Accounting Cycle! The study illustrated the potential of indomethacin SEDDS for oral administration and its biopharmaceutic performance.33. 2. The Last Brigade! Damineni,S et al (2014) developed self emulsifying drug delivery system of ibuprofen to enhance solubility, dissolution rate which may improve therapeutic performance and drug loading capacity so as to develop alternative to traditional oral formulations to improve bioavailability. In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and co-surfactant respectively.

Formulation development and the accounting, screening was done based on results obtained from phase diagrams and characteristics of resultant microemulsions. The developed SEDDS were evaluated for droplet size analysis, zeta potential, polydispersibility index, viscosity, refractive index, % transmittance, drug content and in vitro diffusion profiles.34. 3. Kumar,S. et al (2014) in this article we have study upper surface of SEDDS. The main advanced topic in this article is solidification process of LSEDDS and Bandwidth Essay, the development of cycle solid SE dosage forms.at the last find he prolems of the system and work by maya, solve it.35. 4. Reddy,M. et al (2014) In this article we have conclude, today huge numbers of the accounting cycle formulation avalables for the increasing poor water solubility of drugs , dissolution rate and bioavailability of insoluble drugs. Romare Bearden! One of the promising techniques is the accounting cycle, Self’Micro Emulsifying Drug Delivery Systems (SMEDDS).

Liquid SEDDS were prepared using LLWL 1349, Labrafac PG as oils and cremophor EL, cremophor RH40 as surfactants and labrasol, transcutol HP as co-surfactants. Tax The Essay Example! Prepared liquid SEDDS were evaluated for stability, particle size, zeta potential and cycle, percent transmittance. Selected liquid formulations were converted to solid SEDDS by adsorbing onto brave new world love a solid carrier Neusilin. Prepared solid SEDDS were evaluated for flow properties and in-vitro drug release studies. Results proved that prepared solid SEDDS have good flow properties and improved drug solubility and the accounting, dissolution profiles (99.95%) when compared to Bandwidth Essay, pure efavirenz.36.

5. Amrutkar,C. The Accounting Cycle! et al (2014) The aim of the present study is to improve solubility and effects, hence bioavailability of Rosuvastatin calcium using self nanoemulsifying drug delivery system (SNEDDS). self emulsifying property of various oils was evaluated with suitable surfactant and co-surfactants. Ternary phase diagram was constructed based on Rosuvastatin calcium solubility analysis for cycle optimizing the light brigade systems. The prepared formulation were evaluated for self emulsification time, dispersibility study, average globule size, Polydispersibility index (PDI). The globule size of optimized system was less than 100nm which could be an the accounting cycle acceptable nanoemulsion range. The average globule size of the selected F2 SNEDDS formulation (Capmul MCM [20%], Tween 20 [40%] and PEG 200 [40%]) was 88.01nm. In vitro drug release studies showed remarkable increase in rocket to the, dissolution of F2 SNEDDS compared to marketed formulation.37. 6. The Accounting! . Choudhary,S.B. et al (2014) revealed formulated and characterization solid self emulsifying drug delivery system (SSEDDS) of domperidone for filling into woman work by maya soft gelatine capsule.

Pseudo ternary phase diagrams were constructed and cycle, liquid SEDDS formulations were prepared which consists of oleic acid, tween 20 and rocket moon, propylene glycol as oil phase, surfactant and cosolvent respectively. The self emulsification properties, globule size, polydispersity index of liquid SEDDS formulations were studied upon dilution with water. The solid SEDDS was prepared by spray drying method and the accounting cycle, kneading method using Aerosil 200 as solid career. The solid state characterization of the solid SEDDS was performed by SEM, DSC, and X-ray powder diffraction. The results from this study demonstrate the potential use of SEDDS as a means of improving solubility, dissolution, and concomitantly the bioavailability.38. 7. .Gikwad,S. et al. (2012) A reaserch on self-emulsifying drug delivery system (SEDDS) to enhance the the last solubility of the poorly water-soluble drug Orlistat. These drugs can be successfully formulated for oral administration, but care needs to be taken with formulation design to ensure consistent bioavailability.

Solubility of Orlistat was evaluated in various nonaqueous carriers that included oils, surfactants, and cosurfactants. Pseudoternary phase diagrams were constructed to identify the self-microemulsification region. The self microemulsification properties, droplet size and thermodynamic stability of the accounting these formulations were studied upon dilution with water.38. 8. . Sachan,R. New World Love! et al. (2010) To develop a formulation For the the accounting cycle improvement of Tax the Rich Essay example bioavailability of drugs with such properties presents one of the greatest challenges in drug formulations dissolution rate which may improve therapeutic performance and drug loading capacity so as to cycle, develop alternative to traditional oral formulations to improve bioavailability. Brave New World! In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and the accounting, co-surfactant respectively. Formulation development and screening was done based on results obtained from phase diagrams and characteristics of resultant microemulsions.39. 9. Liu Y., et al., (2009) optimized and characterized an romare rocket to the moon oridonin SMEDDS formulation using central composite design. In this study effect of concentration of oil andsurfactant and co-surfactant ratio has been studied. Study concluded that, this model is useful for optimization of cycle SMEDDS formulation. In-vitro drug release showed that, there was increase in drug release as compared to work, powder formulation.40. 10.

Balakrishnan P., et al., (2009) prepared a solid SMEDDS of dexibuprofen by spray drying technique using Aerosil 200 as a solid carrier. After conversion in to solid form S-SMEDDS retains its self emulsification capacity. In-vitro drug release showed that, there was increase in drug release as compared to powder formulation. In-vivo study showed that increase in bioavailability. The Accounting Cycle! Study concluded that, in the form of Solid SMEDDS it retains all characteristics of liquid and Rich Essay example, it can become helpful solid dosage form.41. 11. Singh A. K., et al., (2009) prepared and evaluated SMEDDS of the accounting Exemestane using Capryol 90, Cremophore ELP, and Transcutol P. Work By Maya! They compared drug release with marketed formulation in different pH. Cycle! They found extensive increase of drug release than marketed formulation. Brave Love! They also compared absorption of drug with that of drug suspension. They found enhanced drug absorption from SMEDDS.

Study concluded that, SMEDDS have potential of the accounting enhancing solubility, absorption and hence bioavailability of poorly water soluble drug.42. 12. Shaji J., et al., (2008) formulated and evaluated SMEDDS of Celecoxib. Brave! They optimized formulation using 33 factorial design. Particle size was taken as response variable. Study showed that, concentration of the accounting different components showed prominent effect on particle size and appearance of dispersion. They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of brave enhancing solubility, absorption and hence bioavailability of poorly water soluble drug.43.

13. Atef E., et al., (2008) formulated and cycle, evaluated SMEDDS of phenytoin and compared its relative bioavailability with marketed formulation. Results showed that, extensive increase in drug release form SMEDDS as compared to that of the last light marketed suspension. Also in-vivo study showed improvement in bioavailability. Study concluded that, SMEDDS is promising formulation to increase drug release as well as bioavailability of poorly water soluble compounds In-vitro drug release showed that, there was increase in the accounting, drug release as compared to powder formulation.44. 14. Fatouros D. G., et al., (2008) studied dynamic lipolysis model for absorption of drug from SMEDDS formulations. They also studied IVIVC with the Bandwidth Essay help of neuro-fuzzy networks.

Study concluded that, in evaluation of SMEDDS for prediction of in-vivo behavior in-vitro dynamic lipolysis model is a possible means.45. 15. Shikov A., et al., (2008) Prepared and cycle, characterized SMEDDS of rocket flavonoids. The Accounting! Prepared SMEDDS formulation was evaluated for Rich self emulsification capacity, droplet size and for bioavailability. Results showed that, They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of cycle poorly water soluble drug. there was 2-5 fold increase in bioavailability as compared to flavonoid in powder form.46. 16.

Woo J. S., et al., (2008) developed SMEDDS of Itraconazole and studied and compared in-vivo study in human volunteers with marketed formulation having double dose. Romare Bearden Rocket! Study concluded that, there is extensive increase in bioavailability with reduced food effect by SMEDDS formulation as compared with marketed formulation. They found enhanced drug absorption from the accounting cycle SMEDDS. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of poorly water soluble drug.47. 17. Mandawgade S. Brave Love! D., et al., (2008) developed SMEDDS using natural lipophile as oil phase and also compared its performance with synthetic oils. For this study beta-Artemether was used as drug.

Oil was previously evaluated for toxicity studies. Prepared SMEDDS was evaluated for globule size, in-vitro and in-vivo study. The Accounting Cycle! Study concluded that, performance of natural lipophiles is better than that of commercially available synthetic oils hence can be used in SMEDDS as it is safe.48. 18. Yi T., et al., (2008) developed a controlled release solid SMEDDS of nimodipine using HPMC. Bandwidth Essay! They have prepared batches by mixing drug with HPMC and another batch by dissolving drug and HPMC in cycle, the SMEDDS. Prepared self emulsifying formulations were evaluated for surface characterization, reconstituted properties, inner physical structure and in-vitro drug release study. Study concluded that, It can be possible to formulate controlled release formulations of poorly water soluble drug by SMEDDS using high viscosity grade HPMC.49. 19.

Yi T., et al., (2008) developed a S-SMEDDS of nimodipine. Prepared S-SMEDDS was evaluated for in-vitro and in-vivo absorption study. They have studied effect of dilution media and enzymatic digestion on solubilization of drug .Results showed that, there is faster dissolution rate of drug from woman work S-SMEDDS than that of conventional tablet and enhancement of absorption as compared to liquid SMEDDS. The Accounting! . Prepared SMEDDS was evaluated for globule size, in-vitro and love, in-vivo study. Study concluded that, performance of natural lipophiles is better than that of commercially available synthetic oils hence can be used in the accounting, SMEDDS as it is safe. Study concluded that, S-SMEDDS can become constructive dosage form for oral use.50. 20. Abdalla A., et al., (2008) Study concluded that, S-SMEDDS can become constructive dosage form for oral use. developed self emulsifying formulation in Bandwidth Essay, the form of pellets by cycle extrusion and Bandwidth Essay, spheronization technique. Cycle! In. Woman Work By Maya Angelou! this study they found that, droplet size decreases after dilution. Study concluded that, solubilzation depend on concentration of secretions like bile salts and phospolipid.

SMEDDS can besuccessfully transformed into pellets form and can become another method to encapsulate material into hard gelatin capsule.51. 21. The Accounting! Lu J. Tax The Rich Essay Example! L., et al., (2008) developed SMEDDS of 9NC to enhance bioavailability and anticancer effect. They prepared microemulsion of 9NC and characterized for citotoxicity and bioavailability study. Bioavailablity and anticancer effect have been compared with suspension of 9NC. Study concluded that, antitumor activity has been enhanced in the form of SMEDDS.52. 22. Patel D., et al., (2007) developed SMEDDS of Acyclovir. Prepared formulations were evaluated for different parameters.

Absorption of drug from SMEDDS was compared with plain drug solution. Cycle! Results showed that, there was 3.5 fold increases in bioavailability by SMEDDS. Study concluded that, bioavailability of drug can be enhanced using SMEDDS approach. . Results showed that there were 5 fold reductions in plasma cholesterol and 4 fold reductions in plasma triglycerides when compared with reference formulation of drug suspension. Love! Study concluded that, there was better biopharmaceutical performance of drug from cycle SEDDS.53. 23.

Cirri M., et al., (2007), formulated oral liquid spray formulation of xibornol using SMEDDS. Prepared formulations were evaluated for rheological, stability, SAXS and in-vivo study. The study found that, SMEDDS can be used to prepare stable and effective oral liquid spray formulation. Absorption of drug from SMEDDS was compared with plain drug solution. Results showed that, there was 3.5 fold increases in bioavailability by SMEDDS. Study concluded that, bioavailability of drug can be enhanced using SMEDDS approach.54.

24. Patil P., et al., (2007) formulated a SEDDS for simvastatin. Prepared SEDDS was evaluated for turbidometric analysis, particle size, in-vitro drug diffusion and in-vivo study in rat. Results showed that there were 5 fold reductions in plasma cholesterol and 4 fold reductions in plasma triglycerides when compared with reference formulation of drug suspension. Study concluded that, there was better biopharmaceutical performance of drug from SEDDS.55. 25. Patel A. R., et al., (2007) formulated and evaluated SMEDDS of fenofibrate. From solubility study of drug in different components oil, surfactant and co-surfactant were selected and pseudo ternary phase diagram were constructed. From this SMEDDS were prepared and brave, evaluated for thermodynamic, dissolution, stability study and lipid lowering capacity. Cycle! Study concluded that, SMEDDS can improve dissolution rate and woman by maya, hence bioavailability of the accounting drug which become substitute for oral drug delivery system. Study concluded that, there was better biopharmaceutical performance of brave new world drug from SEDDS.56.

26. The Accounting Cycle! Shen H., et al., (2006) prepared and evaluated SMEDDS of atorvastatin using Labrafil, PEG and Cremophor RH40. Work! From solubility study of drug in different components oil, surfactant and co-surfactant were selected and cycle, pseudo ternary phase diagram were constructed. SMEDDS capsule of negative doping atorvastatin were prepared and drug release were studied and compared with conventional tablet. Results showed that release of drug was much higher from SMEDDS capsule than that of tablet. Study concluded that, bioavailability of drug can be enhanced using SMEDDS capsule than conventional tablet. controlled release of drug can be obtained from the accounting lipid formulations in tablet dosage form.57.

27. Boonme P., et al., (2006) characterized colloidal state in woman by maya, microemulsion system. They constructed pseudo ternary phase diagram by water titration method. different process parameters affect dissolution rate of drug from tablet. Study concluded that, controlled release of drug can be obtained from lipid formulations in tablet dosage form. Different samples were prepared by the accounting cycle keeping surfactant concentration of 45 % and by varying proportion of water.

Prepared samples were evaluated for appearance, viscosity, conductivity, DSC, SEM and NMR. Study concluded that, if composition has 15 % of water, it contain reverse micelles, W/O emulsion obtain if it contain 15-30 % of water and brave new world love, it gives O/W emulsion of it contain more than 35 % of water.58 28. Nazzal S., et al., (2006) evaluated different process parameters which affect release of drug from SNEDDS in tablet dosage form. Solid preparation was prepared to study absorption of drug in rat and cycle, dog. Prepared tablets were evaluated for dissolution and stability studies. Rich Essay Example! Results showed that, different process parameters affect dissolution rate of drug from tablet. Cycle! Study concluded that, controlled release of drug can be obtained from lipid formulations in tablet dosage form.59 29.

Wu W., et al., (2006) prepared SMEDDS of silymarin. From solubility study of drug Tween 80, ethyl alcohol and ethyl linoleate were selected as formulation components Solid preparation was prepared to study absorption of woman by maya angelou drug in rat and dog. Results showedthat Florite RE gives more absorption of drug both in rat and dog. Results showed that, there is increase in particle size as increase in drug loading in formulation. Drug release was much higher than that of crude drug powder. Study concluded that by using SMEDDS bioavailability of silymarin can be enhanced.60 30.

Ito Y., et al., (2005) prepared solid formulation of the accounting cycle gentamicin using different adsorbents and surfactant to enhance absorption of drug. Florite RE, Neusilin US2 and Bandwidth Essay, Sylysia 320 were used as adsorbents and Labrasol was used as surfactant. The Accounting Cycle! Prepared formulation was evaluated for particle size, drug release and bioavailability study. Negative Of Blood Doping! Results showed that, there is increase in particle size as increase in drug loading in cycle, formulation Study concluded that by using adsorbent and surfactant system oral solid formulations can be prepared so as to negative effects of blood, increase absorption of poorly absorbable drug.61 31. The Accounting Cycle! Sha X., et al., (2005) studied effect of of the light charge and dilution on TEER and permeability of mannitol by formulating SMEDDS using Labrasol and also studied effect of dilution of the accounting surfactant on ZO-1 and F-actin. Study concluded that, SMEDDS of negative effects both positive and negative charge containing Labrasol are capable of enhancing the paracellular tramsport of mannitol across Caco-2 cell at the accounting different dilutions. , there was significant increase in rate and extent of absorption of drug as compared to capsule. It was also found that, there was 1.5 fold increases in bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for oral delivery of poorly water soluble drug such as simvastatin.62 32. Woman! . Cycle! Subramanian N., et al., (2004) developed and optimized SMEDDS of Celecoxib using simplex lattice mixture design. Prepared SMEDDS were evaluated for Clarity, solubility, in-vitro dissolution and in-vivo study. Bandwidth Essay! Results showed thatRelative bioavailability with capsule was found to be 132 %. Study concluded that, prepared formulation will reduce variability in the accounting, absorption and rate and gives rapid onset of action of drug.

It was also found that, there was 1.5 fold increases in bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for oral delivery of woman poorly water soluble drug such as simvastatin.63 33. Kang B. K., et al., (2004) prepared SMEDDS of the accounting simvastatin using Carpryol 90, Cremophor EL and Carbitol. Brave New World Love! Prepared formulations were evaluated for Sustained drug release was achieved by using Silicon dioxide as gelling agent which retarded release of drug, in-vitro dissolution study and bioavailability study. Results showed that, in-vitro of drug was much higher that that of conventional tablet. It was also found that, there was 1.5 fold increases in bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for oral delivery of the accounting poorly water soluble drug such as simvastatin.64 34. Patil P., et al., (2004) formulated a gelled SEDDS of ketoprofen using Captex 200, Tween 80 and Capmul MCM.

Sustained drug release was achieved by using Silicon dioxide as gelling agent which retarded release of drug. Study concluded that, as concentration of gelling agent increases it increase droplet size of emulsion formed which helps in negative, slowing drug diffusion. It was also found that, as concentration of co-surfactant increase drug release from the accounting dosage form also increases.65 35. Holm R., et al., (2003) importance of brave love this examined oral absorption and lymphatic transport of cycle halofantrine in Bandwidth Essay, SMEDDS containing triglycerides, Sustained drug release was achieved by cycle using Silicon dioxide as gelling agent which retarded release of Rich Essay drug. Maisine-35-1 and Cremophor EL. Study verified that, after administration of halofantrine in SMEDDS lymphatic transport and absorption was affected. Study concluded that, by using differentstructure of triglycerides it is achievable to the accounting cycle, enhance lymphatic transport of compound without affecting its availability.66 36. Itoh K., et al., (2002) the aim of this present researched topic improved solubility of Bandwidth Essay N-4472 by formulating self-micro emulsifying system using Gelucirei??i?? 44/14, HCO and SDS. Cycle! Study concluded that, formulate sedds to enhance the bioavability and the last of the, formed stable microemulsion droplets. SDS showed vital role in stability of microemulsion droplets.67 37.

Agarwal V., et al., (2000) investigated effect griseofulvin SMEDDS addition to silica and cycle, silicate on flow properties and in-vitro drug release. Rich! Results showed that, increase in surface area increases dissolution of drug. Study concluded that, nature and amount of adsorbent affect flow properties and dissolution of cycle drug in SMEDDS. In-vitro drug release showed that, there was increase in drug release as compared to powder formulation.68 38. Kim H. J., et al., (2000) developed SMEDDS of idebenone using Labrafil 2609, Labrasol. Transcutol and new world love, Plurol oleique WL1173 so as to enhance bioavailability by the increasing the solubility of the poorly water solublr drug. Results showed that, in-vitro dissolution rate of drug were increased 2 folds than that of tablet. Study concluded that, SMEDDS can be used as substitute for traditional oral formulations to enhance bioavailability of idebenone.69 39. Chen G. L., et al., (1996) the importance of this present researched study was validated bioanalytical method for determination of Verapamil from plasma by HPLC for the accounting pharmacokinetic study of Verapamil. By Maya Angelou! They also studied sensitivity, specificity, linearity, accuracy, precision and sample stability of the accounting cycle method. For the purpose of sedds evaluation.70 40.

Shah N. H., et al., (1994) the aim of brave this study was investigated emulsification efficiency of polyglycolyzed glycerides (PGG) and polyethylene glycol (PEG). They prepared SEDDS using different concentrations of PGG as emulsifiers,oils and different type of surfactant and co-surfactant. Neobee M5 and Peanut Oil were selected as oil. Drug having good solubility in oil was selected for this study. Study showed that, PGG can be used as emulsifier for cycle preparation of the last SEDDS.71 MATERIAL METHOD 4. MATERIAL AND METHOD 4.1 MATERIALS Table 4.1: List of the accounting cycle materials with sources S. No. Negative Effects Of Blood Doping! Materials Source 1. Telmisartan Skymap Pharmaceuticals, Roorie 2. Tween 80 Loba chemic laboratory regents Mumbai 3. Cycle! PEG 400 Nasco laboratory 4. Methanol Loba chemic laboratory regents Mumbai 5. Hydrochloric acid Loba chemic laboratory regents Mumbai 6. Orange oil Burgone laboratory Mumbai Table 4.2: List of equipments with make S. No. New World! Equipment Make 1. Analytical balance Fuji electronic balance 2. Melting point apparatus Jyoti digital auto melting apparatus 3. UV – Spectrophotometer Jasco japan-v630 4. Dissolution apparatus Jyoti standard dissolution apparatus 5. FTIR Jasco-japan FT/IR/4100 7. The Accounting Cycle! mixing Jyoti lab gwl. INDIA 8. Brave Love! Hot air oven Jyoti lab gwl.

INDIA 9. Water bath Jyoti lab gwl.INDIA 4.1.1 Drug profile: Telmisartan72 Telmisartan is 4’-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1- yl]methyl]biphenyl-2-carboxylic acid. The Accounting Cycle! Structural formula ‘ Figure 3.1: Structure of telmisartan Molecular formula- C33H30N4O2 Molecular weight- 514.6 Definition 4’-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1- yl]methyl]biphenyl-2-carboxylic acid. Content: 99.0 per cent to 101.0 per cent (dried substance). Negative Effects! Category: Antihypertensive. Dose: 20 to 80 mg. Half life: 24 hrs. Appearance: White or slightly yellowish, crystalline powder. Solubility: Practically insoluble in the accounting, water, slightly soluble in methanol, sparingly soluble in methylene chloride.

It dissolves in 1 M sodium hydroxide. It exhibits polymorphism. Melting point: 261 ‘ 263oC. Storage: it should be stored at room temperature (15 – 30 i??i??C), away from moisture and light. Brave New World! Mechanism of action: It is an angiotensin II receptor antagonist. Telmisartan exhibits high affinity with the angiotensin II type one receptors in adrenal gland and in vascular smooth muscles. Cycle! It works by binding to the angiotensin II receptor. It inhibits the action of angiotensin which is new world love, a vasoconstrictor.

Angiotensin also stimulates the synthesis and release of aldosterone. By blocking the vasoconstrictor effect of the angiotensin and blocking the aldosterone, Telmisartan reduces the systemic vascular resistance. Pharmacokinetics: Absorption: After the oral administration peak concentrations (Cmax) of telmisartan are attained in the accounting, 0.5 to 1 hour. Ingestion with food slightly decreases the negative effects doping bioavailability of Telmisartan. Cycle! Absolute bioavailability is dose dependent. At 40 and 160 mg the bioavailability was found to Bandwidth Essay, be 42% and 58%, respectively. Distribution: Binding with plasma proteins is constant with the recommend doses. It is highly binding with the plasma proteins (more than 99.5 %).

It has a volume of distribution of around 500 L. Metabolism: Telmisartan is cycle, metabolized by forming a pharmacologically inactive compound acyl glucuronide by conjugation. The only identifiable compound in the human plasma and urine is the glucuronide. Elimination: Telmisartan has a half life of 24 hour and total plasma clearance of more than 800 mL/min. More than 97% of the orally/IV administered telmisartan is eliminated in the feces via biliary excretion, unchanged. Uses: It is Bandwidth Essay, used to treat high blood pressure (hypertension). Adverse effects: The common reported adverse effects of telmisartan are upper respiratory tract infection (URTI) (7%), Back pain (3%), Diarrhea (3%), Myalgia (3%), and cycle, Sinusitis (3%).

Some rare adverse effects (1%) are abnormal ECG, anemia, angina, angioedema, bradycardia, eczema, epistaxis, gout, and hypercholesterolemia. Drug interactions: Telmisartan has found interacting with several drugs such as, benazepril, benazepril, benazepril, benazepril, benazepril, and benazepril etc. Bandwidth Essay! Caution is advised when combination will be used. Dosage forms: It is commonly used in the form of tablets of 20, 40, and 80 mg. 4.1.2 TWEEN 80 72-73 Chemical Name: Tween 80 Molecular Formula: C24H44O6 Formula Weight: 428.600006103516 Tween 80 Property Boiling point- 100i??i??C. Dencity – 1.08 g/mL at 20 i??i??C. Vapour pressure- 230 i??i??F. storage temp. The Accounting Cycle! : Store at RT. From- viscous liquid. Water Solubility : 5-10 g/100 mL at 23 i??i??C. EPA Substance Registry System: Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.(9005-65-6)

Tween 80 Chemical Properties,Usage,Production. Yellow to amber liquid. Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Negative Effects Of Blood Doping! Faint odor and bitter taste. Air Water Reactions.

Tween 80 is the accounting, incompatible with strong alkalis and oxidizers. Tween 80 is probably combustible. 4.1.3 ORANGE OIL 72-73:- It was the important and essincial oil can be produse by the cells in the fruits of oranges. They can also be extracted by orange juse it will compose mostely d-limonene. Romare Rocket To The Moon! That will be extract to the oil by distillation. Odour- fresh and the accounting, tangy smell, Coloue- yellow to orange in color. Self life- approximately 6 months.

Origin of the last of the light Sweet orange oil. This evergreen tree has dark green leaves and white flowers and the accounting, bright orange round fruit with roughish skin. The trees are native to China, but are now cultivated extensively in America. 1. It can be used many Curacao type liqueurs. 2. for the flavoring of food. 3. Romare! drink and confectionery. 4. The Accounting! when added to furniture polish. 5. helps to protect against damage from insects. The orange oil are extracted by cold-pressing and yields 0.3 -0.5 %. It can also use for the medicinal perpose that will gives several therapeutic actions are antiseptic, anti-depressant, antispasmodic, anti-inflammatory, carminative, diuretic, cholagogue, sedative and tonic. The main chemical components of brave love orange oil are a-pinene, sabinene, myrcene, limonene, linalool, citronellal, neral and geranial.

1. It is a safe non-toxic, non-irritant and the accounting, non-sensitizing oil, 2. yet care must be taken with it since it can have a phototoxic effect. 3. It should therefore preferably not be applied before going out into Essay sunlight for prolonged periods. Iupac name – polyethylene glycol. – 90.0 cst at cycle 25 i??i??C, 7.3 cst at woman work by maya 99 i??i??C.

PEG 400 properties. 1. (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. 2. Cycle! It is a clear, 4. viscous liquid. 5. Due in part to its low toxicity, PEG 400 is widely used in of the, a variety of pharmaceutical formulations. 1. Cycle! PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons.

2. PEG 400 is strongly hydrophilic. 3. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log ), indicating that when PEG 400 is angelou, mixed with water and hexane, 4. there are only 15 parts of PEG 400 in the hexane layer per 1 million parts of PEG 400 in the water layer.[1] PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in the accounting cycle, aliphatic hydrocarbons. 4.2 Preformulation studies 72,73,74,75. To develop a safe, stable and therapeutically effective dosage form, preformulation studies are necessary to perform. The preformulation studies, which were performed in this project, include identification of drug, melting point analysis, solubility analysis, and brave, quantitative estimation of drug.

4.2.1 Identification tests. ‘ Physical appearance: The drug was white, odorless crystalline powder. ‘ Melting point analysis: Melting point of telmisartan was determined by capillary method using melting point apparatus (Rolex- Digital melting point apparatus). ‘ FTIR study: Drug sample was vacuum dried for 12 h before IR studies. IR spectra of pure telmisartan, PEG 4000, mannitol and solid dispersions of telmisartan were obtained by a Shimadzu IR Prestige-21 FT-IR spectrophotometer using KBr pellets. The scanning range used was 4000 to 400cm-1.

The observed peaks were reported for functional groups. 4.2.2 Loss on drying73-74. It was determined on 1 g drug by cycle drying it in a hot air oven at 105oC. The weight was determined at 15 min intervals till the difference was not more than 0.5 mg. The total difference in weight should not be more than 0.5%. 4.2.3 Determination of ‘max 73. Accurately weighed sample of 10 mg of brave new world love telmisartan was dissolved in 50 mL of methanol in a 100 mL volumetric flask and then the volume was made up to 100 mL with methanol.

Then, 1 mL of the accounting this stock solution was pipetted into a 10 mL volumetric flask and volume was made up to the 10 mL mark with methanol. The resulting solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu, Japan). Tax The Essay Example! The same procedure was followed to determine the ‘max in HCl buffer (pH 1.2). The prepared solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu). To determine ‘max in cycle, water, accurately weighed 10 mg sample of telmisartan was dissolved in 50 mL of effects of blood doping methanol in a 100 mL volumetric flask and volume was made up to 100 mL with methanol. Then, 1 mL of the accounting cycle this stock solution was pipetted into a 10 mL volumetric flask and volume made up to Rich, the 10 mL mark with distilled water. The resulting solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu, Japan). 4.2.4 Quantitative estimation of drug73-74. Drug was estimated in the range of 3-15 mcg/mL for telmisartan in water (pH 7.0), HCl buffer (pH 1.2) and methanol.

Preparation of HCl buffer (pH 1.2): 50 mL of 0.2 M KCl was added in a 200 mL volumetric flask then 85 mL of HCl solution (0.2 M) was added in the flask and volume was adjusted to the accounting, 200 mL with distilled water32. 4.2.5 Construction of calibration curve of telmisarta73. 4.2.5.1. Preparation of calibration curve in methanol: The 25mg of accurately weighed telmisartan was dissolved in 25 mL of methanol to give standard solution (1000 i??i??g/mL). Rich Essay! From this standard solution, 3 mL was pipetted out and volume was made up to 100 mL with methanol referred as stock solution of concentration 30i??i??g/ mL. Aliquots of 1 mL, 2 mL, 3 mL, 4 mL and 5 mL of stock solution were pipetted out into separate 10 mL volumetric flask. The volume was made up to the mark with methanol.

This results in samples of cycle 3, 6, 9, 12 and 15 ‘g/mL concentration, respectively. Bandwidth Essay! The absorbance of cycle prepared solution of the last of the light brigade telmisartan in the accounting, methanol was measured at 296.5 nm in Shimadzu UV-1700 spectrophotometer against an appropriate blank. 4.2.5.2. Bearden Rocket! Preparation of calibration curve in HCl buffer (pH 1.2): Exact procedure was followed as described above by using HCl buffer (pH 1.2) instead of cycle methanol. The absorbance was recorded at 296 nm. 4.2.6. solublity of telmisartain in different medium. Solubility of telmisartain was determine in Tax the, the different medium by heand shaking method. 3.3 Formulation 76. 4.3.1 identification of microemulsion region : Determine solubility of telmisartain in different -2 medium then select three medium orange oil as oil, PEG 400 as surfactant and tween 80 as co-surfactant. Micro-emulsion region was identify by constructing pseudo ternary phase diagram with the the accounting help of different proportion of surfactant and co-surfactant (1:1, 2:1, 3:1). They are mix with oils at different proportion (1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2, 9:1) and the complete mixture was titrate with water and noted the equbliurem point.

At which point the mixture will show clear. 4.3.2 preparation of Bandwidth Essay liquid SMEDDS: Due to the higher microemulsion region in cycle, the 3:1 proportion (surfactant:co-surfctant) was selected for the preparation of LSEDDS. 1. Required amount of PEG 400 and romare bearden rocket moon, tween 80 was take and mix with the help of stirrer until they compatibly mix. 2. Aquaretly weight telmisartain and take required amount of the accounting orange oil and mix il. 3. Drug mixture place on water bath until drug completely dissolve in woman angelou, oil. 4. Both the mixture are mix togather on the magnatic stirrer untill they are compleately mix and form a isotropic mixture. 5. Store in the glass bottle.

Table 4.3 chemical requirements. Orange oil 50 ml. Tween 80 12.5 ml. Telmisartain 2000 mg. 4.4 CHARACTERIZATION :76-77. 4.4.1 stability study :76. 4.4.1.1 heating cooling cycle: for the stability study of LSEDDS pass six cycle between hot and cool temperature (40c-450c) with storing not less then 48hrs at each temp. not seen any type of phase sapration. 4.4.1.2 centrifugation test: After passing heating cooling cycle it would be pass with centrifugation test. Cycle! The sample of LSEDDS placed in by maya angelou, centrifuge for 30min and show any type of precipitation. If not seen it would be go to the accounting, the next stability test.

4.4.1.3 freeze thaw cycle: This test is again at cool and hot temperature (-210C to negative of blood, +250C) 48 hrs at each temp. If the LSEDDS pass all the stability parameter means the system becomes stable. 4.4.2 cloud point measurement : 76-77. Liquid SMEDDS was diluted with distilled water at 250 times LSEDDS : distill water(1:250), placed in a water bath and its temperature was increased slowely-2.

Cloud point was measured as the temperature at the accounting which there was a sudden appearance of cloudiness visually. 4.4.3 solubility test .77-78. Solubility of LSEDDS was determine at Bandwidth Essay buffer solution at 1.2ph, 7.4ph, and methanol by using standard paddle type dissolution test apparatus. 4.4.3.1 Preparation of HCl buffer (pH 1.2): 50 mL of 0.2 M KCl was added in a 200 mL volumetric flask then 85 mL of HCl solution (0.2 M) was added in the flask and cycle, volume was adjusted to 200 mL with distilled water. 4.4.3.2 Buffer pH 7.4: Mix 50 mI of solution containing 1.944 per cent w/v ofsodium acetate and 2.946 per cent w/v of barbitone sodium with 50.5 mI of 0.1 M hydrochloric acid, add 20 mI of an 8.5 per cent w/v solution of Bandwidth Essay sodium chloride and cycle, dilute with water to 250 mI.

4.4.4 efficiency of self emulsification :76-77. Using USP- type-II dissolution test apparatus (Veego VDA-8DR). Love! 1 mL of Liquid SMEDDS was added drop wise to cycle, 200 ml of 0.1 N HCl at 37i??i??C. agitate using by using standard stainless at Tax the Essay example rotating paddle at 60 rpm. SMEDDS assessed visually according to the rate of the accounting emulsification and final appearance of the emulsion. 4.4.5 Robustness to bearden to the, dilution :76. it can be studied by the accounting by diluting LSEDDS at different concentration with distill wate. 1. Prepare HCL buffer solution PH 7.4, PH 1.2. 2. Prepare dilution with both the solution at following concentration. 3. Store for 12 hrs.

4. Example! Observe any type of phase saperation or pracipation. 4.4.6 % transmittance :76. For the determination of % transmittance take. 1. 1ml of LSEDDS and diluted till 100ml with distilled water. 2. Scan this sample in the uv spectroscopy. 3. observe any type of turbidity and % transmittance. 4.4.7 Dye solubility test : 76. This test can be perform for the conformation of oil in water nature of LSEDDS by observing sopntenious dispersion. 1. Take water soluble dye and sufficient quantity of LSEDDS. 2. Rapidly incorporate dye into the accounting the system. 4.4.8. in vitro drug release:76-77.

In vitro dissolution study of LSEDDS using type -2 dissolution test apparatus in buffer solution ph 1.2, ph 7.4 at 370 c. 4.4.8.1 Drug release in effects of blood doping, buffer solution at 1.2 PH :- 1. Prepare buffer solution 1.2 PH by the help of indian pharmacopeia. 2. Fill in the accounting cycle, the type-2 dissolution test apparatus upto 900ml . 3. Palce 2ml sapmle of LSEDDS in Bandwidth Essay, the apparatus. Start the assumbaly. 4. Take sample after regular interwal. 5 min, 10 min,15 min,30 min,45 min,60 min,90 min,120 min. 5. The all sample was filtered with whatmant filter paper.

And dilute upto 10ml. 6. If there concentration is high then take again 1ml to all the the accounting cycle samples and and dilute again upto 10ml. 7. The sample was scan into the uv spectroscopy at 296nm. 4.4.8.2 Drug release in buffer solution at 7.4 PH :- 1. Prepare buffer solution 7.4 PH by the help of brave new world love indian pharmacopeia. 2. Fill in the type-2 dissolution test apparatus upto 900ml . 3. Palce 2ml sapmle of LSEDDS in the apparatus. Start the the accounting assumbaly. 4. Take sample after regular interwal. 5 min, 10 min,15 min,30 min,45 min,60 min,90 min,120 min.

5. New World! The all sample was filtered with whatmant filter paper. And dilute upto 10ml. 6. The Accounting Cycle! If there concentration is high then take again 1ml to all the samples and and dilute again upto 10ml. 7. The sample was scan into the uv spectroscopy at 296nm. 4.4.9 drug contant:76-77-78-79. drug content of LSEDDS should be determine by romare bearden to the diluting 1 ml sample of LSEDDS with distill water.

Take there absorbance in uv-spectroscopy at296nm. 1. Take 1ml sample of LSEDDS and dilute with distill water upto 100ml. 2. If the the accounting concentration of sample was high then furthers 1ml sample dilute with distill water upto 10ml. 3. Scan this sample in uv-spactroscopy. 4. Calculate there percentage by the help of work angelou leaner line equation. RESULT AND DISCUSSION. Table 5.1: Melting point of telmisartan.

S. No. Melting point Result. 5.1 LOSS ON DRYING: The results were within the acceptable limit which is 0.5%. Table 5.2: Loss on drying. S.No. Time (min) Weight (mg) Difference in weight (mg)

Total difference 2.9. 5.2 FTIR spectroscopy: FT-IR spectra of pure drug telmisartan and cycle, its solid dispersion which are shown in figure 7.1 and 7.4. Brave! There was not any significant interaction found between drug and carriers which confirms the the accounting cycle stability of drug in the formulation. Table 5.3: Major peaks observed in FTIR spectrum of telmisartan. S. No.

Standard peak Observed peak Comments. 1. The Last Of The Light! 3059.1cm-1 3080 cm-1 C-H stretching (aromatic) 2. 2958.8-2868.15 cm-1 2870-2738.92 cm-1 C-H stretching (aliphatic) 3. 1697.36 cm-1 1687.71 cm-1 C=O stretching. 5. 1521.84-1458.18 cm-1 1462.04 C=C stretching ring. Figure 5.1: FT-IR spectra of pure telmisartan.

5.4 LEMDA MAX OF TELMISARTAIN IN DIFFERENT SOLVENT SYSTEM : Table 5.4: Solvent systems, their parameters and values. S.No. Solvent system Parameters Values. 1. Cycle! Methanol i??i??max 296.5 nm. Beer’s law range 3 – 15 mcg/mL. Regression line equation y = 0.050x + 0.007. Regression coefficient (R2) 0.999. 2. Buffer 7.4 i??i??max 298 nm. Beer’s law range 3 – 15 mcg/mL. Regression line equation y = 0.043x + 0.004.

Regression coefficient (R2) 0.999. 3. Rich Example! HCl buffer (pH 1.2) i??i??max 296 nm. Beer’s law range 3 – 15 mcg/mL. Regression line equation y = 0.046x + 0.007. Regression coefficient (R2) 0.999. 5.5 CALIBRATION CURVE OF TELMISARTAN IN DIFFERENT SOLVENT SYSTEM. Table 5.5: Calibration curve of telmisartan in HCl buffer pH 7.4 and HCl buffer pH 1.2 at cycle ‘max 298 nm and 296 respectively. S.No. Concentration (i??i??g/mL) HCl buffer pH 7.4 HCl buffer pH 1.2. Absorbance Regressed Absorbance Absorbance Regressed Absorbance.

2. 3 0.139 0.133 0.153 0.145. 3. 6 0.270 0.262 0.294 0.283. 4. 9 0.401 0.391 0.423 0.421. 5. 12 0.537 0.520 0.567 0.559. 6. 15 0.657 0.649 0.706 0.697. S.No.

Concentration (i??i??g/mL) Methanol. Absorbance Regressed Absorbance. Table 5.6: Calibration curve of telmisartan in methanol at ‘max 296.5 nm. Figure 5.2: Calibration curve of telmisartan in buffer 7.4 ph at 298 nm. Figure 5.3: Calibration curve of telmisartan in HCl buffer pH 1.2 at brave love 296 nm. Figure 5.4: Calibration curve of telmisartan in methanol at 296.5 nm.

5.6 SOLUBILITY OF TELMISARTAIN : Table 5.7: solubility of telmisartain in different medium. S.NO. MEDIUM SOLUBILITY. 1. Water Insoluble. 2. Hcl Springly soluble. 3. Methanol soluble. 5. The Accounting! PEG400 Soluble. 6. Tween 80 Springly soluble.

7. Tween 20 Springly soluble. 8. Span 80 Springly soluble. 5.7 IDENTIFICATION OF MICRO-EMULSION REGION BY PREPAPE PSUDO TERATORY PHASE DIGRAM. In this formulation preportion of surfactant and co surfactant is 1:1. Table 5.8: identification of micro-emulsion region. SMIX : OIL END POINT. In this formulation preportion of surfactant and co surfactant is 2:1. Table 5.9: identification of micro-emulsion region.

SMIX : OIL END POINT. In this formulation preportion of Bandwidth Essay surfactant and the accounting, co surfactant is 3:1. Table 5.10: identification of micro-emulsion region. Smix : OIL END POINT. Result- Best micromulsion was found to be In formulation 3 at 5:5 proportion of oil and mixture of surfactant and co-surfactant denoted as smi. 5.8 FORMULATION OF LIQUID-SELF EMULSIFYING DRUG DELIVERY SYSTEM (LSEDDS). 5.8.1 chemical requirement: Table 5.11: chemicals requirements . Orange oil 50 ml. Tween 80 12.5 ml. Telmisartain 2000 mg/2gm. 5.9 EVALUATION OF LSEDDS.

5.9.1 stability study. Physical stability was important parameter in the emulsion system it can be affected the performance of the negative effects system, it can be occurs due to the precipitation of drug. The Accounting! Due to the poor stability of system bioavability of drug also affected. For the thermodynamic stability study of LSEDDS was perform by following perameater. 1. Heating cooling cycle.

2. Centrifugation test. 3. The Last Light! Freeze thaw cycle. When system can not show any type of phase separation during heating cooling cycle then syatem can be tested in the centrifugation for the drug pricipation then apply freeze thaw cycle for the stress test. 5.9.1.1 heating cooling cycle : 40c No separation. 450c No separation. 40c No separation. 450c No separation. 40c No separation. 450c No separation. 40c No separation.

450c No separation. 40c No separation. 450c No separation. 40c No separation. 450c No separation. Table 5.12: six cycle of heating cooling temp. Result ‘ not seen any type of phase saperation. 5.9.1.2 Centrifugation test:

Result- LSEDDS was centrifuge for 30 min there was not seen any type of precipitation and phase saperation. 5.9.1.3 freeze thaw cycle. Table 5.13: three cycle of cycle -210c to +250c. Cool temp. No change.

Hot temp. No change. Cool temp. No change. Hot temp. No change. Cool temp. No change. Hot temp. No change. 5.9.2 cloud point measurement. Table 5.14: Cloud point. Sample Cloud point.

Result- cloud point of this emulsion system was found to brave new world, be more then 860c. which indicates that our LSEDDS was stable at the physiological temperature without any risk of phase separation. 5.9.3 solubility study: Table 5.15: solubility of LSEDDS. Medium Solubility time. Buffer solution PH 1.2 Less than 5min. Buffer solution PH Less than 5min. 0.1 N HCL Less than 5min.

Result ‘ solubility of the accounting this system was found to be less than 5min which indicates that the formulation also use in the sustain release drug delivery system with maximum bioavability. 5.9.4 Efficiency of self-emulsification. Sample Efficiency of Rich LSEDDS. 1 Less than 1min. 2 Less than 1min. 3 Less than 1min. Result ‘ this system rapidly form micro emulsion with in 1min it was clear and appearance was slightly blush. 5.9.5 Robustness to dilution : Table 5.15: dilution with different solvents. Concentration Water Buffer solution.

PH 1.2 Buffer solution. 50 times No change No change No change. 100 times No change No change No change. 500 times No change No change No change. 1000 times No change No change No change. Result ‘ in the robustness dilution not seen any type of phase separation and cycle, pracipation. Result- % trasmittance of this system was found to be 93.5. 5.9.7. Brave! dye solubility test.

Result- type of emulsion was conform by the accounting using dye solubility test in which a water soluble colourfull dye rapid incorporate in the LSEDDS and observe. Which indicates that the continuous phase in this system is water. so it was conform that the LSEDDS was o/w micro emulsion. 5.9.8 in-vitro drug release profile. 5.9.8.1 drug release in buffer solution PH1.2. Table 5.16 in-vitro drug release of of the light brigade SEDDS. % cumulative drug release. Plain drug LSEDDS. 10 min 7.35 42.43. 15 min 11.63 61.36. 30 min 1.83 75.45.

45 min 18.64 83.33. 60 min 23.31 89.02. 90 min 27.15 95.26. 120 min 29.48 95.56. Figure 7.4 commulative % drug release of SEDDS and plain telmisartain in PH 1.2. 5.9.8.2 drug release in buffer solution PH 7.4.

Table 5.17 in-vitro drug release of SEDDS. % cumulative drug release. Plain drug LSEDDS. 10 min 11.38 47.39. 15 min 14.92 54.43. 30 min 19.61 73.13. 45 min 24.48 81.68. 60 min 28.29 90.83. 90 min 32.62 96.54. 120 min 33.46 98.12.

Figure 7.6 % commulative drug release of LSEDDS and plan telmisartain in PH 7.4. 5.9.9 drug content estimation. Table 5.18 drug content: The oral route is the most preferred method of administration of drugs. The Accounting Cycle! Unfortunately, this route is not possible for 50% of currently marketed drug compounds due to their low solubility in water and low oral bioavailability. We study that self-emulsifying drug delivery system (SEDDS) can be used for the improvement of bioavailability of the drug. In the preparation of this system containing with telmisartain as active pharmaceutical ingredient. To increase bioavailability solubility of this drug. Due to poor solubility of telmisartain it cannot be formulate in the oral drug delivery system. But with the help of LSEDDS it’s possible to give telmisartain via oral drug delivery system.

After the complete study of woman angelou LSEDDS we conclude that the system was very useful for the active drug molecules having poor solubility. 1. The Accounting! Yamamoto, J. and H. Tanaka, prepare neomatic phase in the liquid micro-emulsion. Bandwidth Essay! Nature (London), 2001. 409(6818): p. 321-325. 2. Porter, C.J.H., N.L. The Accounting Cycle! Trevaskis, and W.N. Charman, Lipids and lipid-based formulations: for the optimization of drug delivery by Bandwidth Essay oral route lipophilic drug. Nature Reviews Drug Discovery, 2007. 6(3): p. 231-248.

3. Cycle! Humberstone, A.J. and W.N. Charman, the oral drug delivery of poorly water soluble drugs. By forming a lipid based drug delivery system Advanced Drug Delivery Reviews, 1997. 25(1): p. 103-128. 4. Of The Light Brigade! Kommuru, T.R., et al., Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and the accounting, bioavailability assessment By forming a lipid based drug delivery system Advanced Drug Delivery. Int J Pharm, 2001. 212(2): p. 233-46. 5. Neslihan Gursoy, R. and S. Benita, Self-emulsifying drug delivery systems (SEDDS) for work improved bioavability of poorly water soluble drug. Cycle! Biomedicine Pharmacotherapy, 2004. 58(3): p. 173-182.

6. Hauss, D.J., et al., prepare lipid based drug delivery system for poorly water soluble drug LTB4 inhibito to of the, enhance there solubility as well as bioavability. The Accounting! Journal of woman by maya angelou Pharmaceutical Sciences, 1998. 87(2): p. Cycle! 164-169. 7. By Maya! Gao, P., et al., Development of cycle a super saturable SEDDS (S-SEDDS) formulation of paclitaxel with improved there solubility that can enhance the bioavability of poorlt water soluble drug. Journal of by maya angelou Pharmaceutical Sciences, 2003. The Accounting! 92(12): p. 2386-2398. 8. Woman Work By Maya Angelou! Patil Pradeep, R., et al., Bioavailability assessment of ketoprofen incorporated in gelled self-emulsifying formulation to improve the cycle bioavability by example using lipid based drug delivery systemAAPS PharmSciTech, 2005. 6(1): p. E9-13. 9. Kang, B.K., et al., Development of self-microemulsifying drug delivery system(SMEDDS) for improve the bioavability by cycle using lipid based drug delivery. International Journal of Pharmaceutics, 2004. 274(1-2): p. 65-73.

10. Palamakula, A. and rocket to the, M.A. The Accounting Cycle! Khan, Self-Emulsifying Drug Delivery Systems (SEDDS) for improving bioavability of cytotoxicity of Bandwidth Essay oils used in coenzyme Q10. International Journal of Pharmaceutics, 2004. 273(1-2): p. 63-73. 11.

Montenegro, L., et al., Effect of the accounting oil phase lipophilicity on in vitro drug release from o/w microemulsions with low surfactant content. Drug Development and Industrial Pharmacy, 2006. 32(5): p. 539-548. 12. Attama, A.A. and M.O.

Nkemnele, formulation and evaluation SEDDS using a biodegradable homolipid from Capra hircus. International Journal of Pharmaceutics, 2005. 304(1-2): p. Bandwidth Essay! 4-10. 13. Djordjevic, L., M. Primorac, and M. Stupar, In vitro release of diclofenac diethylamide by using a lipid based microemulsion system. International Journal of Pharmaceutics, 2005. 296(1-2): p. Cycle! 73-79. 14. Agatonovic-Kustrin, S., et al., Prediction of a Stable Microemulsion Formulation for the Oral Delivery of a Combination of Antitubercular Drugs Using ANN Methodology. Pharmaceutical Research, 2003.

20(11): p. 1760-1765. 15. Taha, E.I. Response surface methodology for the development and evaluation of new world love self nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate. Pharmaceutical Development and Technology, 2005. 10(3): p. 363-370. 16. Liu, Y., et al., Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin for improving bioavability of oridonin. Int.

J. Pharm., 2009. 365: p. The Accounting! 136-142. 17. Holm, R., I.H.M. Jensen, and brigade, J. Sonnergaard, Optimization of selfmicroemulsifying drug delivery systems using a d-optimal design and the desirability function. Drug. Dev. Ind.

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