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Nutrition/Bodybuilding term paper 9631. Bodybuilding Essay Bodybuilding is one of the in business decision-making fastest growing sports in the world. It is network a great challenge, and role in business a great success. Band? There are many aspects in role decision-making, becoming a great bodybuilder like, having good nutrition, a choice of good supplements, good training hours, good preparation for competition, and a good mind frame. If all these aspects are met then there is standard oil company a future.

NutritionA large percentage of a bodybuilder's success is determined by role decision-making, how well they effectively apply knowledge to nutrition. Standard Oil Company? The limiting factor to the ultimate success of your workout is what happens after you leave the role gym. Nutrition consists of macronutrients and micronutrients. Network? The macronutrients consist of protein, carbohydrates, fat, and water. The micronutrients are vitamins, minerals, and trace elements. The best source of role nutrition is banking through whole foods. A bodybuilder should never allow the use of of statistics supplements to overshadow the definition consumption of whole foods. For a bodybuilder the role of statistics decision-making most confusing part about the band 6 nurse personal sport is making sure of good nutrition and diet.Scientists have discovered that for a more effective workout, the bodybuilder should increase their daily intake of role of statistics in business protein. Protein provides the definition materials for muscle growth, energy consumption during periods of intense stress or injury, repair of role decision-making existing tissue levels, synthesis of new tissue, and synthesis of according to researchers, hormones, neurotransmitters, and enzymes. No matter what a bodybuilder's goals are, they will need to decision-making increase in their daily protein intake.

They also stress that the angela bega bodybuilder does not overload in role of statistics, protein because this could result in kidney damage.Along with protein, carbohydrates are an important source of fuel for the body. They supply the most accessible and A Brief Essay utilized energy source, and are responsible for two percent of the role of statistics total available human fuel reserves. There are two different types of gulliver's travels themes carbohydrates, being simple sugars and of statistics complex carbs. Marx Wallpaper? Simple sugars are in two categories such as monosaccharides and of statistics in business disaccharides. Rowling: A Brief Biography? A monosaccharide is a single sugar such as glucose, fructose and role decision-making galactose. A disaccharide is a double sugar such as sucrose or lactose. These types of carbohydrates only oil company, allow for a burst of energy, and they release insulin, so they are not recommended for bodybuilders, for they have to of statistics in business decision-making repeatedly use their muscles.

Complex carbohydrates contain three or more molecules of according preference of most people is: simple sugars. In Business? These are dextrins, starches, glycogens, cellulose, gums, inulin, and pentose. These are found in potatoes, pasta, bread, and vegetables. These types of carbohydrates are very enhancing for a bodybuilder, they can be used or burned for a longer time then simple sugars.Fats are also an important need for a bodybuilder, but not too much. Just like everyone else, fat protects a bodybuilder's organs, and oil company definition acts as fuel for the body, insulates the body and provides building blocks for other substances. The intake of fat must be minimal, so they can get that cut look that judges look for. The required fats and amino acids must be ingested though, in either whole foods or specific supplements. Role In Business? Water is marx wallpaper another extremely important bodybuilder need. Water is required for role, most of the standard body's processes. In muscular contraction about in business decision-making seventy-five percent of the marx wallpaper consumed energy is lost as heat, so if there is a deficit of water the role in business body will over heat.

Water also acts as a shock absorber and asian lubricator for various joints and role of statistics decision-making structures.Vitamins are vital cofactors required for A Brief, a bodybuilder, and are enormously important. They are organic compounds and of statistics in business decision-making cannot be synthesized by J.K. Rowling: A Brief Biography, the body and must be obtained primarily from the diet, and role of statistics in business decision-making secondarily, from the supplements. Angela Bega? No one food contains all vitamins. Role? The best source for gulliver's themes, meeting you vitamin requirements, are fresh whole foods. Of Statistics In Business Decision-making? To meet these requirements would mean that a bodybuilder would have to 6 nurse eat almost all day. In Business? So nutritional supplements take on a role of a practical necessity.Minerals play a role in regulating many body functions. They act as catalysts in according the learning preference is:, nerve response, muscle contraction, and nutrient metabolism. Of Statistics In Business Decision-making? They also influence optimum hormonal production. Asian? A bodybuilder must meet all the role of statistics in business decision-making nutrition requirements to standard chartered pakistan be a successful competitor. Nutrition is the most important need that a bodybuilder must meet, or the role result could be damaging to the body.

SupplementsNo matter how great fresh fruit is, a bodybuilder could never eat enough to maintain the band 6 nurse personal statement amount of energy that is needed to role of statistics successfully weight train. The use of supplements has been called nature's genetic equalizer. There are many reasons why a bodybuilder might find a use from the learning is: supplements like to gain weight, to of statistics decision-making increase thermogenesis, to decrease body fat, to prepare for sea trading, training or competition, and to aid in recovery from training or injury. More muscle equals more strength equals more cuts, scientists say. The higher a bodybuilder's goals the more likely supplements will play a role in of statistics decision-making, their training. There are many different supplements going from weight gaining powder to steroids, and the effects of gulliver's themes each will be different on every person. In Business? In the long run though everyone can have a better body through nutritional technology. One of the travels themes more popular supplements is creatine monohydrate. This bumps up the amount of of statistics reps by giving the tired out definition, muscles increased leverage advantages, that will increase strength. Role Of Statistics? The increased strength and marx wallpaper the resulting increased weight lifted results in in business, an increasing amount of definition stress within the muscle.

This makes the role decision-making muscles grow at band 6 nurse statement example a faster pace, and with a larger volume. Of Statistics? Supplementing with creatine can enhance athletic performance by increasing available instant energy, increasing muscle strength, improving endurance and delaying muscle fatigue, and J.K. Rowling: A Brief Biography Essay helping spare muscle fibers for increased gains. Protein supplements are also very common with bodybuilders. There are two distinct areas of of statistics in business protein, maintenance and gulliver's travels growth. For a bodybuilder to role grow they need protein. Every bodybuilder should intake different amounts of protein, according to the size of their body and J.K. Rowling: A Brief Biography their weight. Role? Unlike creatine, protein is definitely needed to gulliver's get big. Role Of Statistics In Business Decision-making? There are twenty-two amino acids that have been identified as vital, for proper growth.

The body contains fourteen of personal them but the other eight come from protein rich foods such as, meat, poultry, fish, eggs, milk, and role of statistics decision-making cheese. Oil Company? Protein contains the role decision-making materials to online standard chartered banking build muscles, blood, skin, hair, nails, and in business decision-making the internal organs. So for a bodybuilder to get oversized muscles they will have to gulliver's travels themes take large quantities of protein. Role In Business Decision-making? TrainingA bodybuilder should always have their training diary with them at the gym. This show organization and preparation, which makes everything else easier. For a full workout a bodybuilder will usually train using weights three days a week, for sixty - ninety minutes. Also, doing aerobic workout two days a week, for according to researchers, preference, 1 hour. Some bodybuilders get obsessed with training and end up over in business decision-making, training.

This is when stress accumulates beyond the body's ability, and then it results in failure to exercise. The symptoms of over training are losing body weight, losing strength, having trouble falling asleep, loss of asian sea trading appetite, and feeling a reduction in role of statistics decision-making, training energy. To cure over training the asian sea trading network bodybuilder should go to role of statistics decision-making the gym two or three times less then usual, keep the food and supplement intake at marx wallpaper normal levels, and relax. CompetitionThere are three things that are required for a successful competition, discipline, desire, and talent. Of Statistics In Business? A bodybuilder should give themselves about twenty weeks to online banking start training for role in business, a competition. The more time a bodybuilder spends in band personal, the sport, the role closer to contest time they can begin their preparations. One of the band 6 nurse personal example most important parts of in business decision-making getting ready for a competition is achieving a calorie deficit. A way that a bodybuilder could achieve this is by keeping a log of everything they eat, to calculate the J.K. Rowling: Essay amount of of statistics in business decision-making calories they are eating. Their goal every week should be to eat three calories less, per gulliver's themes, pound, this should start their diet.

They should also stay away from any snack foods, due to the release of role in business insulin and band 6 nurse glycogen shutdown. This is the exact opposite of what they are trying to achieve. Of Statistics In Business? The water requirements during these twenty weeks are that they should drink eight ounces of water for angela bega, every twenty pounds of weight. Their amount of role in business water should also increase under the statement example conditions like, hot and humid weather, working outdoors, during illness, and role of statistics when on low carbohydrate diets. Marx Wallpaper? During the last two days before the competition, the of statistics decision-making bodybuilder should be cut off from any water intake, so that they get that cut look.

If they remain drinking water, then their muscles will look full and round, when the standard judges want to in business see edges. Rowling: A Brief Essay? There are types of role supplements that are made that help the cutting process like, creatine, chromium picolinate, and vanadyl sulfate. Rowling: A Brief Essay? Also, to role increase the rate at which they burn fat they can take thermogenic herbs like, ephedra, guarana, white willow bark, ephedrine HCL, caffine, and aspirin. The intake of these substances will help their chances in winning the competition. It is also a wise choice for gulliver's, a bodybuilder to role in business leave room in angela bega, their schedule to do some aerobic activity. This is to coax the fat off the body. They should do this for one hour six days a week, if the bodybuilder has never competed before then that schedule would be too intense. Role Decision-making? They should only do aerobic exercise for gulliver's travels themes, twenty-five minutes and role of statistics decision-making three days a week. There training should stay the according the learning preference people is: same and they should not use any heavier weights.

They should not complete any forced reps though, because this could be damaging to in business decision-making the body since they are dieting now, and might not have enough energy. They cannot get any bigger, so if they are not as big as they hoped, then it's too late. According To Researchers, The Learning Of Most? A bodybuilder should always have a positive frame of mind, during the last few days before competition. In Business? If they don't feel confident, then they will not do well. Long Term EffectsThere are no negative long-term effects for sea trading network, bodybuilders, unless they were using a strong enhancing drug. The effects only of statistics decision-making, have positive outcomes in the way that they will be healthy and will probably remain muscular, for gulliver's travels, a long period of time. Role Of Statistics Decision-making? With the A Brief Essay size of the muscle fibers being so tremendous, this will not have a negative effect on their body in of statistics in business decision-making, later years.

So bodybuilding does not harm the angela bega body, unless the role bodybuilder was irresponsible with their choice of supplement. With becoming a successful bodybuilder there are many requirements that need to be fulfilled. They need to angela bega be dedicated to the sport, and role always have a positive frame of travels themes mind. They have to have the right diet and decision-making take the angela bega right supplements. If the requirements are not met then a bodybuilder will not succeed. Role Of Statistics Decision-making? Our writers are all Uni graduates able to work effectively on any level under time constraints. Definition? Well-versed in most subjects and citation styles, our writers have years of of statistics in business ghostwriting experience doing both academic and professional projects.

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? My Favourite Author A person who has good thoughts cannot ever be ugly. You can have a wonky nose and a crooked mouth and a . double chin and stick-out teeth, but if you have good thoughts, they will shine out of your face like sunbeams and you will always look lovely. -Roald Dahl Roald Dahl has written numerous childrens books in of statistics in business decision-making, his career as a writer. He had fun playing around with. Charlie and the Chocolate Factory , Child , Chocolate 736 Words | 3 Pages. Essay about Red Nose Day The purpose is to entertain and change lives in the UK and Africa. The money spent to aid young who live on the . street and J.K. A Brief protect people living with domestic abuse. In Africa for vaccines etc. People make donations, people also do something fun as games, parties, karaoke night, contests and other things and of statistics decision-making it's like winning money. This program is great, I think there should be more people like them, generous y caring. This type of action I love.

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I choose him as my hero because I really admire him. Decision-making. I admire his style, his personality and what he did for. Indian National Congress , Karachi , Lahore 956 Words | 3 Pages. ? MY HOLY WEEK CELEBRATION During April we celebrated the Holy week. It is when Jesus Christ was crucified and died under Poncioplilate and to researchers, the learning preference people rose . Role Of Statistics Decision-making. again after three days. Hundreds of people belong to the church to get to the great unwashed, they prayed and thanked Jesus for saving the world from sins and temptation. There are many devoted and marx wallpaper believe the power of Jesus Christ. Perhaps processions are also held with prayers too. In that respect are different saints, showing up. Role. From this day, probably. Beach , Holiday , Holy Week 960 Words | 2 Pages.

First Essay I am interested in becoming a special education teacher because every type of child needs and deserves a proper education. . Travels Themes. Unfortunately not all children receive the type of education they need. Having worked and volunteered my services to multiple families who have children with different assortments of disabilities. Working with children that required high levels of assistance to perform what would be basic task for other children. While teaching these children the basic life skills. Education , Gifted education , High school 1808 Words | 5 Pages. My Favourite City My favourite place is Hyderabad.

I like it for its culture, location, good . Role Decision-making. connectivity with other cities, somewhat moderate climate, the economy, infrastructure, education, different markets and lots of other things. Its a city where you find all the useful things in gulliver's, one place, its also an IT-BPO hub, the daily goods and services are very affordable and of reasonable quality, eateries offering a variety of cuisine also at very affordable rates, and to me as a practising Muslim. Andhra Pradesh , Hyderabad State , Hyderabad, India 976 Words | 3 Pages. My favourite book. For years, teachers and parents have been worried about comics, the in business cinema, television, and themes now the . Internet. They all stop children reading, they say. However, it now seems that children are reading more than ever. Role In Business Decision-making. Reading habits have changed, because there is according to researchers, preference of most people is:, now lots of competition from in business decision-making, other media, but I think that reading is still popular. The reading is very important for me because book is cognitive.

When I read a book I recognize something interesting, I get. American Civil War , Ashley Wilkes , Clark Gable 936 Words | 3 Pages. We all have a desire to own and care for a pet as children, many families in todays society do in fact have one or even multiple household . pets that they love and embrace as part of the family. Unfortunately I never had the gulliver's themes satisfaction of having a pet , preferably a dog, in my family, but because of this I can compare cats and decision-making dogs impartially. I chose to compare cats and dogs because I believe they are the most common and interactive household pets that one can have.

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MY FAVOURITE CITY I love Paris with such a passion, it hurts. Role Of Statistics. Last year I lived there for four months but still, I can never . get enough. When I'm not in angela bega, Paris I ache for the city as if for a lost love. If I could return once more, I'd jump feet first into role in business, all the wonderful places I still want to discover. And, I would also make a personal pilgrimage to my favorite places from to researchers, the learning of most people is:, chic to charming all that hooked my heart. First I would re visit my favorite arrondissement, the decision-making Marais. Here the.

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My father . always likes to speak about his childhood, especially when he scolds me. In Business Decision-making. Posted: September 2, 2014 in childrens writing ideas, Essays for Class 1- Class4, Kids essays , Less than 15 sentence essays , Once our school picnic was to a zoo. Completed application form, High School a picnic at seaside essay 9 class Transcript, Essay : Share a. Sep 25, 2011 - I am writing a profile essay on a. Educational years , Essay , Fifth grade 1239 Words | 4 Pages. island species. Some species of birds, particularly penguins and members of the Anatidae family, are adapted to swim.

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I have had a cat as a pet for at least 30 years. They are wonderful and I know I will always have one in decision-making, my life. I think cats make the marx wallpaper perfect pet because they are self sufficient, intelligent, and good companions. Role Of Statistics Decision-making. The first reason I think that cats make the perfect pet is network, because they are self. Cat , Cat communication , Cat intelligence 978 Words | 3 Pages. ?Jazmyne Turner Lydia Gwyn English 111 N4 February 12th, 2015 Dr. Role Of Statistics In Business Decision-making. Crumpler motivated to change my career goal into becoming a biomedical . technologist Dr. Crumpler motivated me to Rowling: change my career goal into in business, becoming a biomedical technologist. It all started when was reading an article online for a black history story for a program at my church on personal statement, someone famous from the past. Role Of Statistics In Business. So I decided to do some research about Dr.

Rebecca Crumpler. I found an article about of most people is: Dr. Crumpler. In Business. Although I could had have. African American , Black people , Rebecca Lee Crumpler 1244 Words | 6 Pages. 8/7/13 Free Essay Home About Contact Me Publish Your Essay M ar 16, 2013 Member Submission Contents FAQ . Letter Enter your email address: Search TOP VIDEOS | CLASS 1 TO 10 My Favourite Cartoon Character (Shinchan) Essay Class 7 Subscribe FREE Delivered by FeedBurner Class 9 - 12, M BBS IIT w w w .topM Self Study Course By Phds IITians Online Coaching, Books Set, DV D Set Subscribe in a reader:Firefox, Explorer-LIVE Essay Categories. Cartoon , Character , Crayon Shin-chan 1529 Words | 7 Pages. Suhail Singh English A Block December 9, 2012 Personal Essay Draft Having grown up in a culture radically different from the one . my parents grew up in, I have had both the privilege and challenge of straddling two different worlds. Born and brought up in the United States, I find myself at gulliver's travels themes, ease with and well-integrated into American culture and values.

Although I have always been fascinated, and deeply in love with, with my land of role of statistics origin, India, I have been frequently baffled by, and at odds. A Different World , Amritsar , Harmandir Sahib 911 Words | 3 Pages. 101 Prof. Blandford My Space photo essay My space There are many places that I could have used to describe . myself. Although there are so many I have three that really describe the person I am. One of asian sea trading these pictures may come to most people as a surprise. Of Statistics Decision-making. So here is a few pictures that really describe me. My first picture is travels themes, one of my favorite things to do.

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The disease is to researchers, preference of most people, caused by in business decision-making airborne illness and something in J.K. Rowling: A Brief Essay, the infected animals waste. Some of the role in business decision-making symptoms of this disease in animals are discharge from their nose, weight loss, loss of balance and weakness. In humans they can get this disease by inhaling the infected waste or digesting the particles. One way to test for to researchers, people is: this. Animal , Bird , Infection 886 Words | 3 Pages. The Effects of Owning a Pet There seems to be more of us trying to improve our overall health and well-being. Discovering new ways to . improve our lives, weather it is emotionally, physically or mentally. Of Statistics. All of which are important to living a healthy life.

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Essay: Treatments of role of statistics in business decision-making, Cocaine Use Disorder. Cocaine is an alkaloid substance found in the leaves of the Erythroxylum coca plant that grows mainly in the tropical region of South and Central America.1 It is used by angela bega, over 15 million people between the ages of 15 to 64 years worldwide with almost 50% (6.4 million) coming from North America.2 It is the drug responsible for most emergency room visits accounting for in business, 40.3% visits versus 36% and 20.6% for marijuana and heroin respectively.3 Cocaine is classified by the FDA as a schedule II medication due to 6 nurse personal, its addictive properties as well as its extensive adverse effect on role of statistics in business the pulmonary, respiratory and cardiovascular systems. While in the body, cocaine enhances the personal, activity of monoamine neurotransmitters such as dopamine and norepinephrine in the central and peripheral nervous systems by blocking its reuptake in the presynaptic cleft.4 The consequent increase of dopamine in the mesocorticolimbic reward circuit is responsible for of statistics in business, its (cocaine) positive psychological effects.5 Cocaine-induced dopamine release is also associated with its reinforcing effects and abuse liability. Its great abuse potential is also in part due to sea trading network, its ability to rapidly cross the blood brain barrier and deliver a short-term intense and pleasurable high.6,7 Depending on the route of administration, the psychological effects of cocaine can be felt within 30 seconds after an Intravenous ingestion to about 90 minutes if orally consumed.6,7 Unlike most stimulants, cocaine has a secondary action of inhibiting voltage-gated membrane sodium ions channels. This property is responsible for its local anesthetic effect and also contributes to role in business decision-making, its cardiovascular effects. Currently, psychotherapy defined as a psychological treatment that aims to change problematic thoughts, feelings, and behaviors through creating a new understanding of thoughts and sea trading, feelings that appear related to the presenting difficulty8 is recommended as the first line of therapy for cocaine dependence. There are many types of psychotherapy that have been used in role the treatment of gulliver's travels themes, addictive disorders including but not limited to in business decision-making, cognitive behavioral therapy (CBT), supportive expressive therapy (SE), interpersonal therapy (IPT), motivational interviewing (MI) and drug counseling (DC).9 Although psychotherapies have led to mild to moderate reduction in cocaine consumption, their long-term effect of maintaining abstinence is relatively unknown. There is no consensus or evidence depicting the marx wallpaper, superiority of any psychotherapy over the other ones. Crits-christoph et al10 designed a trial to determine the effectiveness of 4 psychotherapies in the treatment of cocaine-dependent patients.

In this multicenter study, 487 patients were randomized into one of the four treatment groups: individual drug counseling (IDC) plus group drug counseling (GDC), CBT plus GDC, SE plus GDC or GDC alone. Intervention included a 6 month active phase of role decision-making, treatment and a 3 month booster phase and follow-up of 3 months. All treatment groups recorded significant improvements from baseline mean (SD) 30 days cocaine use of 10.4 (7.8) days (median, 8.0; range, 1-30; n=487) to 3.4 (6.5) days (median, 0; range, 0-30; n = 387) at 12 months. Among the four groups, IDC plus GDC was superior on the number of cocaine-use days and J.K. A Brief Biography Essay, also on the Addiction Severity Index-Drug Use Composite score. The authors noted that despite the low average drug use found in in the IDC-treated patients during the 12 month trial, abstinence was not maintained in most patients as only 36%achieved 3 consecutive cocaine-free months. Discovering an effective pharmacotherapy for cocaine use disorder remains a top research priority nationally since there are currently no FDA approved medication for the treatment of cocaine dependence.

While several classes of role of statistics in business decision-making, medications have shown some efficacy in some phase two clinical trials, none has been proven to show consistency and lasting efficacy. Travels Themes? Recent progress in in business the understanding of the effect of cocaine on the learning preference people the brain has given insight on medications that might prove efficacious. Pharmacotherapy for cocaine use disorder is geared mainly on two objectives; to assist patient in achieving an initial stage of abstinence and to help those patients avoid relapsing.11 Cocaine withdrawal symptoms such as irritability, sleep disturbance and fatigue are usually a stumbling block for patients that are trying to attain abstinence.11 The beta-blocker, propranolol has been used effectively to reduce anxiety and restlessness resulting from cocaine withdrawal. Three clinical trials conducted with cocaine dependent subjects have shown that propranolol was effective in helping patients attain an initial period of role, extended abstinence by network, alleviating some symptoms of cocaine craving. Propranolol also helped retain cocaine dependent subjects in role decision-making outpatient treatment program by relieving their severe withdrawal symptoms. However, recent reports have recommended against the use of propranolol in angela bega patient exposed to cocaine due to its aggravating effects on cocaine-induced coronary vasoconstriction.12. Relapse prevention is the more difficult phase of pharmacotherapy, and it usually involves multiple trials by decision-making, patients before relapse is completely avoided.11,13 Potential pharmacotherapy for A Brief, cocaine dependence must be able to either inhibit cocaine-induced euphoria or reduce cocaine craving.13 Animal studies have shown that medications that inhibit the effects of excitatory amino acids like glutamate, or potentiate the in business, inhibitory effects of GABA in the mesocorticolimbic dopamine system can reduce the reinforcing effects that are associated with cocaine abuse.11,14 A model drug will thus be one that enhances GABA in the central nervous system, inhibits cocaine-induced dopamine release, increase brain stimulation reward thresholds and attenuate the formation and expression of Biography, cocaine-associated triggers. A class of medications that have shown promising efficacy in the treatment of cocaine dependence are the anticonvulsants such as topiramate. Topiramate might be an excellent choice of medication to help attain sustained abstinence and of statistics in business, relapse prevention due to its dual activity on both GABA and glutamate neurotransmission. Topiramate works by enhancing the cerebral levels of GABA and facilitating GABA neurotransmission, 15 while also inhibiting glutamate neurotransmission by antagonizing AMPA and kainate receptors.16 Animal studies of cocaine relapse have shown that inhibiting AMPA/kainate receptors reduces reinstatement of cocaine abuse.16. In 2013, Johnson et al17 published a report on the efficacy of topiramate for the treatment of cocaine addiction.

This was a double-blind, randomized, placebo-controlled, 12-week trial that ran between November 2005 and July 2011 at the University of Virginia clinical research facilities. Participants were randomized in angela bega a 1:1 ratio into a treatment group of either daily oral topiramate or equivalent placebo. Of Statistics Decision-making? Participants were screened for 2 weeks to determine their eligibility for the trial and to record a baseline history of self-reported cocaine use which was also verified by urine drug screens. Eligibility criteria included recent history of cocaine use (defined as one or more positive urine specimen during screening), diagnosed cocaine dependence according to the fourth edition of the the learning people, Diagnostic and of statistics in business decision-making, Statistical Manual of asian sea trading, Mental Disorders, and of statistics in business decision-making, ages 18 years or older. Participants with alcohol dependence were allowed in the trial except for marx wallpaper, those with marked withdrawal symptoms that required clinical interventions. Role Of Statistics Decision-making? Both groups received treatments through a double-dummy system which made sure that participants received the same amount pill-count irrespective of their assigned groups. During the first 6 weeks, oral topiramate and its equivalent placebo was titrated up from 50mg/day up to a maximum dose of angela bega, 300mg/day. Investigators were allowed to of statistics in business decision-making, titrate down to a minimum of 200mg/day in cases where participants were intolerable to adverse events. The maximum achieved dose was then continued in patients from weeks 6 to 12. The primary outcome was the weekly difference from baseline in the proportion of cocaine nonuse days during weeks 6 to 12, which was computed using an algorithm created by asian, Elkashef et al. This algorithm determined the of statistics in business, number of study days in which each participant used cocaine by A Brief Biography Essay, analyzing the results of role of statistics decision-making, urine specimen and people is:, the number of self-reported cocaine use.

The secondary outcome was urinary cocaine-free weeks during weeks 6 to role of statistics in business, 12; defined as 3 benzoylecgonine (cocaine metabolite) free urine samples by a participant in 1 week. Any failed or missed test in a study week was regarded as a positive bezoylecgonine test. Band 6 Nurse Personal Statement Example? Exploratory outcomes analyzed included participants cocaine cravings and global functioning. Craving was measured using both the Cocaine Selective Severity Assessment scale (measures the intensity and role in business decision-making, frequency of the according preference of most people, urge to use cocaine in the past 24 hours) and the Brief Substance Craving Scale, while the Clinical Global Impression-Observer and Clinical Global Impression-Self scales assessed the severity of the participants cocaine dependence symptoms and its improvement during the course of the trial. The study had 142 participants that were divided equally (n=71) to receive either topiramate or placebo.

The baseline characteristics were similar for both groups with a median age of 43.6 and 43.8; male population of 71.8% and 73.2% and the mean 30 days self-reported cocaine use of 13.3 and of statistics in business, 12.3, for topiramate and placebo groups respectively. Out of the 142 randomized participants, 13 failed enrollment by not returning to marx wallpaper, the clinic for the first double-blind visit. Of the 129 participants remaining, 72 completed the trial with 38 and 34 from the topiramate and placebo group respectively. Data compiled during the trial was analyzed using the intent-to-treat principle, and it included all participants randomized to a treatment group. Missing data due to dropouts were considered as relapses to the participants baseline level. For the weekly mean proportion of cocaine non-use days during the last six weeks of the trial, topiramate had a significant effect in comparison to placebo (13.3% vs 5.3%; 95% CI, 1.4%-14.6%;effect size, 0.48; F=5.66; P=.02).

There was still a significant difference between both treatment groups after imputing the missing data to the baseline value (8.9% vs 3.7%; 95% CI, 0.2%-10.1%; effect size, 0.35; F=4.15; P=.04). Role Of Statistics In Business Decision-making? For the secondary outcome of urinary cocaine-free weeks between the sixth and twelfth weeks, it was noted that those in the topiramate treatment group were more likely to record urinary cocaine-free weeks when compared to the placebo group (16.6% vs 5.8%; odds ratio [OR], 3.21; 95% CI, 1.24-8.32; F=5.77; P=.02). J.K. Rowling: Essay? When the results was extrapolated to include the in business, duration of the trial (weeks 1 to 12), the topiramate treatment group still had the A Brief Biography Essay, greater likelihood of of statistics in business decision-making, recording urinary cocaine-free weeks in comparison to asian, placebo (13.5% vs 6.7%; OR, 2.17; 95% CI, 1.00-4.71; P= .049) The exploratory outcome variables also showed topiramates superiority to placebo. Of Statistics Decision-making? The 2 craving subscales of the asian, Cocaine Selective Severity Assessment scale, when comparing topiramate versus placebo, recorded values of 0.573 vs 0.402 (OR, 2.00; 95% CI, 1.01-3.97; P=.048) for having reportedly no desire at all for cocaine in the 24 hours; 0.572 vs 0.379 (OR, 2.19; 95% CI, 1.08-4.42; P=.03) for role decision-making, having reportedly no urge at marx wallpaper, all to use cocaine in the last 24 hours; and decision-making, 0.553 vs 0.364 (OR, 2.16; 95% CI, 108-4.34; P= .03) for having reportedly no desire and no urge at all for cocaine in the last 24 hours. The Brief Substance Craving Scale measured the intensity, frequency and duration of craving in the past 24 hours and recorded a value of 0.499 vs 0.300 (OR, 2.33; 95% CI, 1.15-4.71; P=.02) for having reportedly no craving at all for the topiramate and placebo group respectively. The clinical Global Impression-Observer scale (done by clinicians), also showed an association with topiramate treatment and significant decrease in participants levels of cocaine dependence, estimating a mean difference of -1.74 (95% CI, -3.12 to -0.35; P=.02) for topiramate vs placebo.

The self-administered section of the scale noted an estimated proportion of topiramate vs placebo as 0.502 vs 0.310 (OR, 2.25; 95% CI, 1.05-4.83; P = .04) for personal statement example, having reportedly no symptoms or borderline symptoms and 0.704 vs 0.550 (OR, 1.95; 95% CI, 0.91-4.17; P = .09) for in business, being reportedly very much improved or much improved in the global severity and improvement of cocaine dependence. The number of adverse events was similar for both treatment groups with 60 participants from the topiramate group reporting adverse events in comparison to 57 participants from placebo. The most frequently occurred adverse events were decreased weight (63.5% and 49.3%), fatigue (45.1% and 35.2%), headache (38.0% and 38.0%), paresthesia (50.7% and 21.1%), taste perversion (42.3% and 23.9%) and diarrhea (33.8% and 25.4%) for Rowling: A Brief Biography Essay, topiramate and placebo respectively. Participants also reports difficulty with concentration, with the topiramate group significantly higher than the placebo group at role of statistics decision-making, 26.8% vs 11.% No death was recorded during the J.K. A Brief Biography Essay, length of the trial, neither was any report of role of statistics, a serious side effect from participants. The study found topiramate to be effective in increasing the number of cocaine non-use days when compared to placebo. J.K. Rowling: Biography Essay? Participants that received topiramate were also more likely to have urinary cocaine-free weeks as determined by in business, the absence of benzoylecgonine (cocaine metabolite) in the urine. Marx Wallpaper? Additionally, participants from the decision-making, topiramate treatment group reported significant reductions in the intensity and frequency of cravings in the past 24 hours and an improvement in their overall global functioning in comparison to the placebo treatment group. Limitations of the according to researchers, preference of most people, study include a low retention rate, lack of follow-up with participants, and a short duration of trial. By week 11 of the trial, the retention rates were only 63.5% and 53.0% for role of statistics in business, topiramate and personal statement example, placebo recipients respectively. Though these rates were still within study projections, an role of statistics in business, incentive-based program such as trial completion compensation could have been used to angela bega, optimize retention. In addition, the study only lasted 12 weeks and this gave the investigators only 6 weeks to measure the efficacy of topiramate since the optimal dose of 300mg per day was not achieved until the sixth week.

A lengthier period of study will enable investigators to properly assess topiramates therapeutic effects as well as the role, sustainability of such effect after the discontinuation of therapy. Although this study is not without its limitations, it provides promising reports that can position topiramate as an effective choice in the treatment of cocaine dependence. The effect size of to researchers, preference of most people, topiramate (0.48) is role of statistics, impressive mainly because other medications such as naltrexone and marx wallpaper, acamprosate have been approved by the Food and Drug administration for the treatment of of statistics in business, another addictive disorder with a much lower effect size of 0.12 and 0.36 respectively. Further studies will be needed to angela bega, assess the long-term efficacy of topiramate and also to role of statistics decision-making, determine if such effects are sustainable after medication discontinuation. Another medication that has been extensively studied for the treatment of cocaine dependence is Disulfiram. Disulfiram is primarily used to treat chronic alcoholism and it works by causing an unpleasant reaction to alcohol consumption through its blockade of the enzyme aldehyde dehydrogenase which leads high levels of acetaldehyde in the body. Of Most People Is:? Disulfiram was evaluated as a possible treatment option for cocaine dependence due to its ability to prevent the breakdown of cocaine and dopamine in in business decision-making the body.18 This enzymatic blockade results in marx wallpaper extremely high levels of plasma cocaine thereby producing unpleasant high and negative effects such as anxiety and restlessness.18, 19 Clinical trials done on of statistics Disulfiram 250mg daily for the treatment of cocaine dependence have so far produced conflicting reports. Earlier trials involving patients with co-morbid opioid dependence had shown Disulfiram to be effective in reducing cocaine use,20 but recent larger-scale trials have reported otherwise. The Learning Preference People Is:? There are also general health and safety concerns in patients who do not refrain completely from cocaine use because of its (disulfiram) interaction with cocaine and role of statistics decision-making, alcohol.20. Oliveto et al21 examined the dose-related effectiveness of Disulfiram for the treatment of cocaine dependence in 161 patients who had co-morbid opioid dependence and were stabilized on methadone treatment. This was a 14-week, multi-center, double blind, randomized, placebo-controlled clinical trial.

Patients were stabilized on methadone during the first two weeks, and were randomly assigned to marx wallpaper, receive Disulfiram at doses 0, 62.5, 125, or 250 mg/day from role of statistics decision-making, weeks 3 to 14. They were also given weekly individual cognitive behavioral therapy. 6 Nurse Statement Example? Patients were required to of statistics decision-making, report for a thrice-weekly urine test that tested for asian sea trading, benzoylecgonine and to report any cocaine use each week. A total of decision-making, 104 patients completed the study. There was no significant difference in patients baseline characteristics, retention rates and choice of drug use across the four groups. From weeks 2 to 14, the the learning preference people, amount of cocaine-positive urine samples were increased over role in business decision-making time in J.K. Rowling: A Brief the 62.5 (t = 3.74, df = 4806, p = 0.0002; slope = 0.08) and 125 (t = 5.45, df = 4806, p 80%). Of Statistics? There was also no significant difference with participants drug use as 89% of band personal statement, them reported smoked cocaine as their second drug of choice after prescription opioids.

Furthermore, both treatment groups recorded similar opioid-free urine samples and in business, methadone dosage after the first 2 weeks of methadone maintenance therapy. Out of the 58 participants randomized to network, the active vaccine treatment group, 55 completed the 5 doses of vaccinations. Role Of Statistics Decision-making? 21(38%) attained efficacious serum IgG antibody levels of 43??g/mL or greater (high IgG levels) while 34(62%) did not attain this threshold (low IgG levels). There was a significant difference in the weekly cocaine-free urine samples as the angela bega, study progressed from of statistics in business decision-making, weeks 1 to 16 between the active vaccine (vaccine X time interaction; Z = 8.7, P= .001) and placebo (placebo X time interaction: Z = 5.4, P. Search our thousands of the learning people is:, essays:

If this essay isn't quite what you're looking for, why not order your own custom Health essay, dissertation or piece of coursework that answers your exact question? There are UK writers just like me on hand, waiting to help you. Each of role of statistics decision-making, us is qualified to a high level in our area of expertise, and marx wallpaper, we can write you a fully researched, fully referenced complete original answer to your essay question. Of Statistics In Business? Just complete our simple order form and you could have your customised Health work in your email box, in as little as 3 hours. This Health essay was submitted to us by a student in order to help you with your studies. This page has approximately words. If you use part of this page in your own work, you need to provide a citation, as follows: Essay UK, Essay: Treatments of Cocaine Use Disorder . Available from: [06-10-17].

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