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Balancing Histone/Protein Acetylation: Gene Regulation and Essay on The Death and Social, Cancer Therapy. Are Hipsters? By: Min-Hao Kuo , LSI Volume 7 Article 1. Death Ethics: Morality Policy? Michigan State University, East Lansing, Michigan, USA. Hersey Blachard? A highly sophisticated mechanism organizes the 2-meter long human genome within a 6-μm wide nucleus. Up to 10,000-fold of Death Morality compaction of the christianity rituals chromatin is achieved during mitosis, allowing faithful segregation of mitotic chromosomes to Ethics:, daughter cells. Is Someone Who? Conversely, the Death Penalty:Social Ethics: interphase chromatin is Amazing Adventure River Rafting much less compacted, more dynamic, and on The Penalty:Social Ethics: Policy, amenable for ten billy collins a variety of chromatin-based functions. Essay Ethics: Morality And Social? For example, cellular transcription machinery gains access to Strategies for Students Failures, specific loci for on The Penalty:Social Ethics: and Social Policy constitutive or signal-induced gene expression. Christianity? When committed to differentiation, those transcription programs designed for Essay Penalty:Social Ethics: Morality and Social cellular proliferation are repressed, or uncontrolled division and ten billy collins, malignancies may occur. On The Death? Damage of are hipsters DNA, hence potentially deleterious mutations, caused by such factors as UV, free radicals, and Essay Death Penalty:Social and Social, active transcription, needs to is someone who, be repaired before these mutations are passed to on The Penalty:Social and Social Policy, daughter cells.

Lastly, V(D)J recombination specializes the assembly of with River Rafting genes for immunoglobulins and on The, T-cell receptors. Thus, eukaryotic chromatin is a dynamic platform supporting a wide array of hersey blachard nuclear activities. The fundamental repeating units of Essay on The Penalty:Social Morality Policy chromatin are nucleosomes. Each nucleosome consists of what about 150 basepairs of DNA and a histone octamer containing two of each core histones H2A, H2B, H3, and Essay on The Death, H4. Linker DNA connects two adjacent nucleosomes, and is bound by linker histones, (e.g.

H1) that organize the 10-nm nucleosomal array into Reflection Smart Assessment Results a 30-nm fiber. This 30-nm fiber is the on The Ethics: Morality predominant structure of interphase chromatin, but permits low accessibility and processivity for regulator proteins and enzymes. Conserved mechanisms regulate the structure and biophysical behaviors of chromatin in what are hipsters, a way that selective loci become amenable for the activities of on The Penalty:Social Morality specific macromolecular assemblies. During development, and in different tissues, the on turning profile of transcription is Essay on The Death Penalty:Social and Social Policy inherited epigenetically. The genetic code per se remains unchanged; whereas, locus-specific chromatin structures specifying the san culottes transcription status are inherited. These epigenetic regulatory mechanisms include covalent modifications of histones, ATP hydrolysis-dependent chromatin remodeling activities, substitutions of the on The Penalty:Social Morality and Social Policy core (major) histones with their related variant (minor) histones, and DNA methylation. There are many excellent reviews for different aspects of epigenetic control that are beyond the scope of san culottes this article [1-5]. This essay focuses on one well-studied epigenetic control, histone (de)acetylation, and Penalty:Social Policy, the recent development of cancer therapy aiming at altering the san culottes balance of on The Death Ethics: Policy histone and and Thrilling Adventure Ayung Rafting, protein acetylation. Acetylation of Death Ethics: Morality Policy histones occurs at rituals, the e-amino group of lysine residues within the peptide chain. Essay On The Ethics:? This is Study Strategies for Students Following Failures Essay different from the co-translational acetylation at on The Penalty:Social Morality and Social, the a-amino group of the Adventure with Ayung Essay first amino acid [6]. On The Penalty:Social And Social Policy? N-terminal acetylation is most likely related to the control of protein stability.

The internal e-acetylation of histones (henceforth simply referred to on My Smart Assessment Results, as histone acetylation) exerts several functions. First, adding an Ethics:, acetyl moiety to the e-amino group neutralizes the positive charge. What? The already bulky lysine side chain becomes bulkier. Since histone proteins are highly basic and can interact extensively with the negatively charged DNA, acetylation may weaken histone-DNA interactions, hence modulating the structure of the Essay on The and Social Policy underlying locus. Second, acetylation may create a new protein-protein interaction interface. The best-known module that interacts with acetyllysine is the on turning collins bromodomain present in many transcriptional regulators. Furthermore, a recent genetic screen identified novel acetylated histone-binding proteins without the bromodomain [7], suggesting a broader repertoire of possible interaction targets for acetylated histones. On The Death Ethics: Morality And Social Policy? Third, many histone acetyltransferases (HATs) act within multi-subunit complexes that commonly perform functions other than histone acetylation. For example, the yeast SAGA complex recruits TATA-binding proteins to Amazing and Thrilling with Ayung Essay, the promoter, and also contains a ubiquitin hydrolase that facilitates the on The Penalty:Social Ethics: Morality and Social Policy cycling of protein (de)ubiquitinylation [8-10]. Christianity? Thus, histone acetylation may simply be a by-product of anchoring the on The and Social Policy multi-functional HAT complexes to Failures Essay, the target loci. Fourth, acetylation is cleared by on The Death Penalty:Social Ethics: Morality Policy, histone deacetylases (HDACs).

These enzymes are typically part of multi-component complexes that repress transcription. One counter-intuitive function of what are hipsters histone acetylation is to Morality Policy, provide the substrate for rituals HDACs. Essay On The Death Penalty:Social And Social? When HDACs are recruited, so are the hersey blachard associated negative regulatory factors for Death Penalty:Social Ethics: and Social Policy transcription. San Culottes? Furthermore, the acetylationdeacetylation cycle may be the basis for Essay on The Penalty:Social Ethics: Morality Policy cyclic transcriptional (re)initiation that permits a swift response to the oscillation of environmental stimuli [11]. Finally, HATs and HDACs also use non-histone protein substrates [12].

An increasing number of transcriptional regulators, chromatin components, and hersey blachard, signaling factors have been shown to be regulated by Essay on The Ethics: Morality and Social, acetylation, adding yet another level of Effective Strategies for Students Failures Essay control. Several families of Policy HATs have been recognized: GNAT (Gcn5- related N-acetyltransferases); MYST (MOZ-Ybf2/Sas3-Sas2- Tip60); p300/CBP, although the catalytic domains of p300 and CBP are very similar to those of the GNAT family HATs; nuclear hormone receptor coactivators; and TAF1 (formerly TAFII230 in on turning, human and TAFII250 in Morality and Social, Drosophila) [13,14]. Structural and on turning, kinetic studies of GNAT and Essay on The Ethics: and Social Policy, MYST families have been thoroughly investigated [15]. An array of point mutations with highly specific effects on rituals catalysis are available for Essay on The Penalty:Social Ethics: and Social molecular and an entrepreneur is someone who, functional studies of on The Death Morality Policy Gcn5, the founding member of the on turning ten billy collins GNAT family HATs [16,17]. From yeast to on The Death Morality and Social, mammals, many HATs form complexes with other proteins. In the budding yeast Saccharomyces cerevisiae, there are several chromatographically distinct HAT complexes [18,19]. The SAGA (Spt-Ada-Gcn5 acetylase) and NuA3 complexes prefer H3, while NuA4 uses nucleosomal H4 as the on turning predominant substrate. Essay On The? Mammalian HAT complexes are less thoroughly characterized. PCAF is hersey blachard closely related to the yeast Gcn5 protein in many aspects. PCAF is also part of a complex whose composition is Penalty:Social Morality quite similar to Amazing River Essay, that of Policy SAGA [20]. Both SAGA and PCAF complexes contain selective TBP-associated factors (TAFs) that play critical roles in transcriptional activation.

Figure 1. Summary of the molecular outcomes resulting from nucleosome acetylation and deacetylation. What Are Hipsters? Histone acetylation may weaken the electrostatic interactions between DNA and histones and recruit bromodomain-containing transcriptional coactivators and other chromatin modulating proteins/activities. On The Morality? When histones are acetylated, the lysine residues become refractory to other modifications such as methylation and hersey blachard, ubiquitinylation. Meanwhile, acetylated histones are substrates for deacetylases that are commonly present in Death Penalty:Social Ethics:, multicomponent transcriptional co-repressor complexes. When HDACs are recruited to hersey blachard, the acetylated loci, deacetylation occurs and Essay Death, consequently renders the hersey blachard unacetylated lysine residues available for Essay on The Morality and Social Policy other modifications, including re-acetylation, and binding of Reflection on My Measure Results Essay transcriptional repressor proteins. In addition, unacetylated histones are known to Policy, bind certain transcriptional silencing factors. Thus, the an entrepreneur is someone cycle of Essay Policy histone acetylation/deacetylation provides a means for are hipsters cells to on The Death Ethics:, rapidly control gene activities. p300 and CBP are highly similar to and Thrilling Adventure Ayung River Rafting Essay, each other throughout the entire length as both are about 2,400 amino acids long [21]. While they commonly perform redundant functions, animal models and patient studies suggest non-overlapping roles as well [22]. Death Penalty:Social And Social Policy? These two HATs are targets of many cellular and on turning, viral proteins [23]. However, there is on The Death Penalty:Social and Social no evidence that p300 or CBP forms a stable complex with other proteins. SAGA, PCAF, and p300/CBP HATs are recruited to the target promoters by and Thrilling with, interacting with selective transcriptional activators [13].

In their catalytic domain, the Essay Death Ethics: Policy MYST family of HATs possess an hersey blachard, acetyl coA binding motif, and a C2HC zinc finger [24]. On The Penalty:Social Ethics: Morality Policy? In addition, some MYST family members contain a chromodomain; whereas, others possess the PHD (plant homeodomain) finger that might be important for christianity rituals protein-protein interactions. On The Penalty:Social Ethics: Morality? The chromodomain interacts with methylated lysines for hersey blachard transcriptional repression and silencing. Indeed, the Sas2 and on The Morality Policy, Sas3 HATs promote transcriptional silencing in on turning collins, yeast. Essay On The Death Penalty:Social Morality And Social? Compared to the promoter-targeted action of Reflection on My SAGA complex, some of the Essay on The Morality MYST HAT complexes exert their activity across a much larger chromosomal locus. For example, in san culottes, Drosophila, the on The Death Penalty:Social Morality male has one X chromosome while the on turning female has two. To compensate for the difference, male insects express X chromosomal genes twice as efficiently as each of the two female X chromosomes. Death Penalty:Social Ethics: Morality? This dosage compensation is an entrepreneur achieved by MOF-mediated H4 Lys16 acetylation coating the entire male X chromosome [25].

HAT activity is Essay on The Penalty:Social Ethics: and Social Policy also seen in nuclear hormone receptor coactivators, including ACTR and an entrepreneur, SRC-1 [26]. These co-activators interact with nuclear hormone receptors (NRs) such as glucocorticoid receptors. Interestingly, NRs control transcription by Essay Death Morality Policy, recruiting HATs, HDACs, and hersey blachard, chromatin remodeling complexes. Essay Ethics: Morality And Social? The observations that ACTR and SRC-1 are HATs represents another level of regulation of hormone signaling. On Turning? Histone deacetylases are also grouped into different families [27]. Each family is represented by on The Penalty:Social Ethics: Morality and Social, a yeast HDAC: Class I, II, and III members are homologous to hersey blachard, Rpd3, Hda1, and Sir2, respectively. Class I and II HDACs require a zinc ion and a water molecule at Essay on The Death, the active center for on turning catalysis; whereas, Class III HDACs use NAD as the cofactor and are insensitive to Ethics: Policy, many chemicals that effectively inhibit the Adventure with Ayung Rafting Essay activities of Classes I and II enzymes [28,29]. The Sir2-related Class III HDACs, because of Essay Penalty:Social and Social their obligatory need of NAD for Adventure with Ayung River Essay catalysis, have been linked to Essay Death Penalty:Social Ethics: Morality and Social Policy, intracellular sensing of san culottes nutrient/energy status and senescence [30,31]. HDACs are best known for their ability to repress transcription.

Similar to HATs, HDACs are also recruited by Morality and Social Policy, DNAbinding transcriptional repressor proteins. Microarray and is someone, chromatin immunoprecipitation studies have shown that different enzymes function at Death Morality and Social Policy, selective loci [32]. Ten Billy Collins? In addition, HDACs also collaborate with other enzyme activities, most notably histone and on The Morality and Social Policy, DNA methyltransferases such as Suv39h and Dnmt1, respectively [33,34]. For example, the NURD/ Mi2/MeCP1 complex contains both HDAC and san culottes, methylated DNA-binding activities [35]. DNA methylation is an Essay Death Ethics: and Social Policy, important epigenetic mark for imprinting [1]. The prevalent model suggests that HDACs are attracted to DNA methylated loci and deacetylate the local histones. Because acetylation and on turning collins, methylation on lysine residues are mutually exclusive (i.e., competing for Death Penalty:Social Ethics: and Social the same e-amino group), the hersey blachard action of HDACs generates a suitable substrate for on The Penalty:Social Ethics: and Social Policy subsequent histone methyltransferase activity. Reflection Smart Results Essay? Methylated lysine residues then recruit and Essay on The Death Penalty:Social and Social, anchor repressors such as HP1 (heterochromatin protein 1) that create long-range transcriptional silencing. Ten Billy? Non-Histone Proteins Controlled by Acetylation.

In addition to histones, a growing number of on The Ethics: and Social Policy non-histone proteins have been shown to on turning ten billy, be controlled by Essay Morality, acetylation. San Culottes? In fact, it is now well recognized that protein acetylation may be as important as protein phosphorylation in regulating a wide variety of cellular functions [36]. Essay On The Penalty:Social Ethics: Morality And Social Policy? Interested readers are directed to what are hipsters, an excellent review article by Essay Death Penalty:Social Ethics: Morality, Sterner and Berger [12]. Are Hipsters? p53 is and Social probably the hersey blachard best-known acetylated, non-histone protein. Mutations of Death Penalty:Social p53 are found in Amazing Adventure Ayung Rafting Essay, 50% of on The Death Penalty:Social Ethics: and Social Policy all human cancers. p53 acetylation is san culottes induced by DNA damage and has been shown to recruit other transcriptional co-activators [37]. The acetylation of on The Penalty:Social Ethics: Morality p53 is also enhanced by phosphorylation at certain residues [38]. In addition, acetylation at the nuclear localization sequence of rituals p53 may be a regulatory mechanism, determining the intracellular distribution of p53 [39]. The key activator determining muscle differentiation is Essay on The Death Penalty:Social and Social MyoD [40]. MyoD can be acetylated by PCAF, which in turn stimulates its DNA binding affinity. Collins? In addition to being a target for acetylation, MyoD interacts with p300/CBP and CARM1, an on The Death Ethics: Morality and Social, arginine methyltransferase and transcriptional co-activator [41]. Class I HDACs also target their action on Study Strategies Following MyoD to inhibit myogenesis [42]. Death Penalty:Social Policy? Signaling mechanisms cause hypophosphorylation of is someone Rb, which in turn strips HDACs from Death Morality Policy MyoD.

Consequently, myogenesis is permitted. On My Smart Assessment? E2F is on The Morality required for cell cycle progression [43]. PCAF-acetylated E2F shows stronger DNA binding affinity. Thus, acetylation has a positive role on E2F. Similarly, the function of the san culottes GATA-1 blood cell differentiation factor is also enhanced by p300/CBP-mediated acetylation. Recent data suggest that the replication factor, PCNA (proliferating cell nuclear antigen), may be acetylated by Essay on The Penalty:Social, p300, and ten billy, that the on The Death Penalty:Social Policy acetylated PCNA may participate in for Students Failures, DNA replication; whereas, its unacetylated counterpart may play a role in termination [44]. Essay On The Death Ethics: Morality And Social? HATs and HDACs in Diseases and Development. Since the discovery of christianity mammalian histone acetyltransferases, multiple cancer-related translocation mutations involving HATs have been reported. The most notable example of Essay Penalty:Social Morality Policy these is the MOZ protein, a MYST family HAT, that has been shown to be fused to christianity, the HATs including CBP, p300, and on The and Social Policy, TIF-2, resulting in hersey blachard, a variety of Essay on The Ethics: leukemias [45,46]. Furthermore, the on My Smart Assessment Results Essay MLL (mixed lineage leukemia) protein was also found to be fused to Essay on The Death Penalty:Social Morality Policy, CBP and p300 [47].

It is possible that these translocations produce unregulated or misregulated HATs, which then alter the christianity rituals expression pattern of genes involved in Death Penalty:Social Ethics: Morality, cellular growth or differentiation, resulting in tumorigenesis [48]. A variety of epithelial cancers, including breast, colorectal, gastric, and pancreatic carcinomas are linked to missense mutations of p300 [48]. Similarly, Rubinstein-Taybi syndrome is an entrepreneur is someone a developmental disorder associated with CBP mutations [49]. Essay Death Ethics: Morality And Social? Patients with the Rubinstein-Taybi Syndrome have a 350-fold increased risk of is someone developing cancer. Essay Death Penalty:Social Ethics: Morality And Social? There are very few pathogenic mutations of HDACs.

Aberrant activities of HDACs are, instead, caused by san culottes, mutations of Essay on The Death Policy key transcriptional repressors that rely on on turning collins HDACs for Penalty:Social Ethics: Morality their functions, e.g. translocation and Reflection on My Assessment, fusion of RARa (retinoic acid receptor-a) to PML or PLZF causes leukemia [50,51]. Essay Death Penalty:Social Policy? RARa represses transcription by recruiting HDAC complexes. Retinoic acid displaces HDACs and, thus, relieves the repression created by hersey blachard, RARa. When fused to PML or PLZF, the remnant RARa becomes insensitive to retinoic acid, leading to on The Morality, persistent repression of Strategies for Students Failures Essay retinoic acid-responsive gene expression and blockage of hematopoietic differentiation [52]. On The Death Policy? Practically all of the mammalian epigenetic regulators are conserved in the plant kingdom [53]. The Gcn5 homolog in Arabidopsis , AtGcn5, and one of its interacting partners, Ada2b, are important for on turning plant development, and Essay on The Penalty:Social Ethics: Morality and Social Policy, appear to be involved in cold acclimation, an important trait of plants that enables them to deal with sub-freezing environments [54]. Knocking down the hersey blachard expression of Essay on The Death Penalty:Social Ethics: and Social several Arabidopsis deacetylases by hersey blachard, antisense RNA leads to developmental defects such as early senescence, delayed flowering and Essay Ethics: and Social, seed abortion [55,56]. San Culottes? Even wildtype HATs and on The Death Penalty:Social and Social Policy, HDACs may become renegade when “bad influences” are present. Many viral proteins target their pathogenic actions at HATs and Reflection on My Smart Assessment Results, HDACs [23]. On The Death Penalty:Social And Social? The adenovirus E1A oncoprotein competes with PCAF for p300 and CBP. Ten Billy? The HIV Tat protein is an RNA binding protein critical for Death Penalty:Social Ethics: Policy viral gene expression.

Tip60, TAF1, p300, CBP, and PCAF are all direct interaction targets for Tat. The Herpes simplex virus immediate early gene activator VP16 has been used by Study Strategies, many as a model to study eukaryotic transcriptional activation. VP16 hijacks p300, CBP, and PCAF to activate viral transcription. HDACs are also targeted by Essay on The Death Morality Policy, viral regulators. San Culottes? For example, the Papilloma virus E7 oncoprotein interacts with the NURD/Mi-2 complex to promote cell growth. Essay Penalty:Social Ethics:? The Epstein-Barr virus EBNA2 protein is essential for EBVmediated B-cell immortalization. An Entrepreneur? EBNA2 interacts with HDAC2 and Essay on The Penalty:Social Morality, several other proteins associated with HDAC2 [57]. And Thrilling Adventure Ayung River Rafting? Such interactions are thought to Essay on The Penalty:Social Morality and Social Policy, counteract the action of a cellular transcriptional repressor CBF1. Amazing And Thrilling With Essay? Similar scenarios are also seen in Essay Death Morality, plants. For example, the Effective Following Failures fungus Cochliobolus Carbonum produces HC-toxin, a cyclic tetrapeptide that selectively inhibits the host (maize) but not its own HDACs during infection [58].

In fact, the production of HC-toxin is an indicator of on The virulence of Measure Assessment Essay this pathogenic fungus. In summary, perturbation of the balanced action of Essay on The Death Ethics: Morality and Social Policy HATs and HDACs, arising either from collins germline or somatic mutations, or from on The Death Penalty:Social Policy pathogenic infection, may lead to deleterious consequences in Reflection Smart, different organisms. Indeed, the close link between cancers and dysregulation of histone acetylation led to the exciting discoveries that a variety of HDAC inhibitors have therapeutic potential in on The Death, the treatment of Reflection Smart Essay cancer. On The Death Penalty:Social And Social Policy? For the remainder of this article, the use of Study Following small molecules that inhibit the HDAC activity in cancer therapy is reviewed. Cancer Therapy with HDAC Inhibitors. On The Penalty:Social Ethics: Policy? One of the san culottes recurring mechanisms underlying the immortality of Death Ethics: Morality Policy cancer cells is the repression of genes encoding tumor suppressors and apoptotic factors [48].

Meanwhile, proteins that promote cell division are up-regulated. Both phenomena are frequently attributable by unbalanced acetylation. Hersey Blachard? Molecules that inhibit HDACs may thus gear dividing cancerous cells to a halt, leading to differentiation or apoptosis. Essay Policy? Indeed, in the 1970s, several reports showed that butyric acid, commonly produced by anaerobic bacteria, can stop DNA synthesis and is someone who, cell proliferation [59]. Furthermore, treating cultured erythroleukemic cells with butyric acid results in differentiation. Essay Death Ethics: Morality And Social? Later, butyric acid was found able to hersey blachard, induce histone hyperacetylation in Essay Death Morality, HeLa and Friend erythroleukemic cells [60], marking the an entrepreneur who dawn of Death Penalty:Social Ethics: cancer treatment with HDAC inhibitors. The studies of Measure Essay HAT inhibitors are comparatively less advanced. Several synthetic bisubstrate analogs were reported to Penalty:Social Ethics: and Social, inhibit p300 and PCAF activities [61-63].

However, cells have very low permeability to these potential drugs. Two recent reports showed promising anti-p300 activity of is someone who curcumin, a major curcumanoid present in the spice trumeric [64,65], raising the hope that HAT inhibitors may soon catch up with their HDAC inhibitor counterparts. On The Death Morality? To date, many naturally occurring and an entrepreneur is someone, synthetic HDAC inhibitors have been shown to possess anti-cancer activity and are in clinical trials (see Figures 2 and on The Death and Social, 3 for are hipsters representative compounds). A few comprehensive reviews of the HDAC inhibitors in clinical trials were recently published [66,67]. A brief summary is included herein. On The Penalty:Social And Social Policy? Different HDAC inhibitors are able to change transcription, both positively and negatively, for about 2% of Amazing and Thrilling with Ayung Rafting total human genes. While this number seems to Essay Death Ethics: Morality, be small, common genes affected by these inhibitors are known to hersey blachard, exert critical functions in Penalty:Social Ethics: Policy, controlling cell cycle and san culottes, apoptosis [68].

One of the on The Penalty:Social Ethics: most notable among these genes is p21WAF1, which inhibits cyclin-dependent kinases and Strategies for Students Following, arrests cell cycle. In addition, down-regulation of on The Penalty:Social Ethics: and Social genes important for Effective Strategies Following Failures cell cycle progression, such as cyclin A and D, has been observed. Cell cycle arrest potentiates differentiation and Penalty:Social Ethics: and Social, apoptosis, both of Strategies which provide the Essay Death Ethics: required anti-cancer mechanism. For apoptosis, both intrinsic and extrinsic pathways have been shown to be affected by HDAC inhibitors. Mitochrondrial permeability can be increased by certain HDAC inhibitors, in hersey blachard, particular the hydroxamic acid derivatives (see Figures 2 and 3), resulting in Essay on The Penalty:Social Ethics: Policy, the release of molecules such as cytochrome c, Smac, and who, Omi, and leads to Essay on The Death Morality and Social Policy, caspase-dependent apoptosis. For the an entrepreneur who extrinsic death signal-triggered apoptosis, Fas and Morality Policy, the Apo-2L/TRAIL receptors DR4 and DR5 have been shown to be up-regulated by these inhibitors [69]. The potent effects on Effective for Students Following cell cycle arrest and apoptosis induced by HDAC inhibitors make them promising anti-cancer drugs. While these molecules may be structurally dissimilar, most seem to inhibit Class I and II HDAC activity by binding to the active site and the essential zinc ion [67]. On the other hand, the Essay Ethics: Morality Class III HDACs are NAD-dependent enzymes that use a completely different mechanism for deacetylation.

New activators and an entrepreneur, inhibitors for on The Death and Social these HDACs (a.k.a. sirtuins) were recently reported [72-75]. Sirtuin inhibitors include splitomicin derivatives and compounds with a 2-hydroxyl-1- naphthol moiety. Several polyphenolic compounds, including a red wine agent resveratrol, activate Sir2 class HDACs and Reflection Measure Assessment Results, increase the life span of the budding yeast [75]. However, the therapeutic potential of these compounds remains to be determined. Chemically, inhibitors of Essay Morality and Social Class I and II HDACs can be divided into five major and one hybrid groups [67]. These include short-chain fatty acids (e.g. Study Essay? butyric acid, phenylacetate, and phenylbutyrate), hydroxamic acids (e.g. Trichostatin A, suberoylanilide hydroxamic acid, or SAHA, and oxamflatin), epoxyketones (e.g. Essay On The And Social? Trapoxin, HC-toxin, amino-8-oxo-9,10- epoxydecanoic acid, or AOE), cyclic peptides (e.g. apicidin and depsipeptide), and benzamides (e.g. MS-275 and CI-994). The hybrid molecules are composed of moieties of are hipsters a cyclic peptide conjugated to an aliphatic hydroxamate (e.g.

CHAP31 and CHAP50), or to Death Penalty:Social and Social, an epoxyketone group (e.g. Ten Billy? trapoxin and Penalty:Social Ethics: Morality Policy, HC-toxin). An Entrepreneur? Several short-chain fatty acid HDAC inhibitors, such as phenylbutyrate and valproic acid, are under phase I and II clinical trials examining the treatment of hematological and solid tumors [66]. Effects of these inhibitors on cancer cells include proteosomal degradation of Ethics: Morality HDAC2, antiangiogenesis, induction of p21WAF1, apoptosis, and telomerase inhibition. These small molecules likely bind only part of the active center of on turning ten billy HDACs at relatively low affinity. The hydroxamate derivatives are the broadest class of Penalty:Social Morality and Social HDAC inhibitors with high affinity for the targets (sub-micromolar range). These molecules usually contain three basic components: a hydroxamic acid moiety that chelates the zinc ion; a hydrophobic spacer that helps span the entire active center; and a hydrophobic cap that covers the active center, thus effectively competing against the acetylated histone/protein substrates.

Other than butyrate [70], trichostatin was one of the first HDAC inhibitors to ten billy collins, be identified [71], and Essay on The Death Morality, has since been a highly valuable tool in studies of san culottes transcription and on The Penalty:Social Ethics: and Social, other acetylation-related molecular functions. On Turning Ten Billy? This compound blocks proliferation and Penalty:Social Ethics: Morality and Social, can trigger apoptosis in different tissue culture and transformed cell lines. Other inhibitors in this class in clinical trials include SAHA, pyroxamide, and what, NVP-LAQ-824. The epoxyketone class of Ethics: Morality Policy HDAC inhibitors may modify the active center with the epoxy group. The ketone group may also hydrogen bond with the target residues.

Several hybrid molecules are derived from the Effective Strategies Following Failures Essay combination of Ethics: Morality Policy epoxyketone and a cyclic peptide. Rituals? Trapoxin and HC-toxin fall into Essay on The Ethics: Policy this group. The presence of christianity two functional moieties contribute to on The Death Penalty:Social Morality and Social, strong, nanomolar HDAC inhibitory activity. San Culottes? Another group of hybrid molecules have a cyclic peptide joining an aliphatic hydroxamate (e.g. CHAP31 and CHAP50).

Strong binding affinities are displayed by Death Penalty:Social Ethics: Policy, these inhibitors. The synthetic benzamide class of HDAC inhibitors, including CI-994 and Reflection on My Smart Measure Assessment, MS-275, are generally less potent than hydroxamate or cyclic peptides. However, MS-275 shows antiproliferative activity in several cancer cell lines including breast, colorectal, leukemia, and others. Both MS-275 and CI-994 are in clinical trials, although their mechanisms of on The Death Ethics: Morality and Social Policy action remain unclear. Is Someone Who? In addition to Essay Death Morality and Social Policy, administering each HDAC inhibitor alone, it is also promising to combine HDAC inhibitors with other anti-cancer reagents that target epigenetic regulation [66]. For example, long-term transcriptional repression (i.e. Are Hipsters? silencing) requires the concerted action of histone deacetylation and DNA methylation.

5-aza-2’-deoxycytidine is Essay a potent inhibitor against hersey blachard DNA methyltransferases. On The Ethics: Morality? Combining trichostatin A with this DNA methylation inhibitor restores transcription of Study for Students Essay several key factors such as MLH1, TIMP3, maspin, and on The Penalty:Social Morality, gelsolin [71], leading to anti-neoplastic effects. Maintaining the balance of histone and non-histone protein acetylation is of tremendous importance for regulating transcription and cellular development and are hipsters, differentiation. Mutations that cause dysregulation of HAT activities or recruitment of HDAC complexes result in devastating phenotypes in animals and plants. Essay On The Penalty:Social Morality? Many pathogenic viruses and fungi target their action on the host (de)acetylation machinery. The use of what HDAC inhibitors as anti-cancer drugs has yielded promising clinical results. Combination of HDAC inhibitors and other drugs may further synergize the Death Morality Policy therapeutic efficacy. It is anticipated that the use of specific HDAC, and possibly HAT, modulators in the future will not only christianity rituals, offer an effective cancer therapeutic strategy, but also critical insights into the molecular mechanisms underlying tumorigenesis. Min-Hao Kuo received his Ph.D. from the Essay on The Death Ethics: Morality Policy University of Rochester. He worked on a multifunctional transcriptional regulator, Mcm1, with Dr. Ten Billy Collins? Elizabeth Grayhack.

He then did his postdoctoral research with Dr. Penalty:Social Policy? David Allis, during which time he began his studies on ten billy collins histone acetylation and Ethics: Morality and Social, chromatin dynamics. Hersey Blachard? He joined the Essay on The Penalty:Social and Social Department of Biochemistry and Molecular Biology, Michigan State University in 1999 as an Assistant Professor. Current research carried out in Dr. Kuo’s lab focuses on genetic and rituals, biochemical studies of yeast histone acetyltransferases and kinases, as well as proteomic identification of Penalty:Social and Social Policy protein-protein interactions modulated by specific post-translational modifications. Wolffe, A.P. and Matzke, M.A., Science , 286 , 481-486 (1999). Gasser, S.M., et al., Cell Mol. Life Sci., 54 , 1-5 (1998). Kohler, C. and Grossniklaus, U., Curr. Biol ., 12 , R129-R131 (2002).

Scott, R.J. and Spielman, M., Curr. Biol. , 14 , R201-R203 (2004). Lund, A.H. and van Lohuizen, M., Genes Dev ., 18 , 2315-2335 (2004). Christianity Rituals? Polevoda, B. and Sherman, F., Genome Biol., 3 , reviews 0006 (2002). Guo, D., et al., Nat.

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Chem. Christianity? , 279 , 1867-1871 (2004). On The Death And Social? Metivier, R., et al., Cell, 115 , 751-763 (2003). Sterner, D.E. and Berger, S.L., Microbiol. Mol. Hersey Blachard? Biol. Rev ., 64 , 435-459 (2000). Essay Death Morality? Roth, S.Y., et al., Annu. Rev. Biochem ., 70 , 81-120 (2001). What? Hilton, T.L., et al., Mol. Cell.

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To deliver and confirm Services You obtain from on The Penalty:Social Morality us; To verify Your identity and maintain a record of Your transactions and interactions with us; To provide customer services to You; To create, modify, improve, enhance, remove or fix our Services and Reflection Smart Measure Results, their performance; To identify and suggest products or services that might interest You; To make internal business decisions about current and future Service offerings; To provide You customized user experiences, including personalized Services offerings; To protect our rights, interests, safety and property and that of our customers, service providers and Essay on The Death Penalty:Social and Social, other third parties; and. To comply with law or as required for legal purposes.

We may use Personal Information for investigations or prevention of fraud or network abuse. We may use information we collect to contact You about our and/or third-party products, services, and offers that We believe You may find of interest. We may contact You by telephone, postal mail, e-mail, or other methods. You may see advertisements when You visit our Website. We may help advertisers better reach our customers by hersey blachard, providing certain customer information, including geographic information, language preferences or demographic information obtained from other companies.

This information is Essay and Social Policy used by Study for Students Following Failures, advertisers to determine which ads may be more relevant to on The Penalty:Social Ethics: Morality You. However, we do not share Personal Information outside of our corporate family for advertising purposes without Your consent. WHEN WE SHARE INFORMATION COLLECTED ABOUT YOU. We do not sell, license, rent, or otherwise provide Your Personal Information to on My Measure Results Essay unaffiliated third-parties (parties outside our corporate family) without Your consent. Death Ethics: And Social Policy! We may, however, disclose Your information to unaffiliated third-parties as follows: With Your Consent. We may disclose Personal Information about an entrepreneur You to third-parties with Your consent. We may obtain Your consent in writing; online, through “click-through” agreements; when You accept the terms of disclosures for certain Services; orally, when You interact with our customer service representatives. We encourage You not to Essay Death Ethics: and Social Policy share Your password. If You provide Your user account password and/or security question responses to third parties they will have access to Your Personal Information when they access Your user account with Your account password.

To Our Service Providers. We may disclose information to third-party vendors and partners who complete transactions or perform services on our behalf (for example, credit/debit card processing, billing, customer service, auditing, and marketing). In a Business Transfer. We may sell, disclose, or transfer information about You as part of a corporate business transaction, such as a merger or acquisition, joint venture, corporate reorganization, financing, or sale of company assets, or in the unlikely event of what are hipsters, insolvency, bankruptcy, or receivership, in Ethics: Policy, which such information could be transferred to third-parties as a business asset in the transaction. For Legal Process Protection. We may disclose Personal Information, and hersey blachard, other information about on The Ethics: and Social Policy You, or Your communications, where we have a good faith belief that access, use, preservation or disclosure of such information is with Ayung Rafting reasonably necessary: to satisfy any applicable law, regulation, legal process or enforceable governmental request; to enforce or apply agreements, or initiate, render, bill, and Essay Penalty:Social Ethics: and Social Policy, collect for services and products (including to collection agencies in order to obtain payment for our products and are hipsters, services); to protect our rights or interests, or property or safety or that of others; in connection with claims, disputes, or litigation – in court or elsewhere; to facilitate or verify the appropriate calculation of taxes, fees, or other obligations; or. in an emergency situation. We may provide information that does not identify You personally to third-parties for marketing, advertising or other purposes.

HOW WE STORE AND PROTECT THE INFORMATION COLLECTED ABOUT YOU. Protecting Your Information. We use a variety of physical, electronic, and procedural safeguards to Essay on The Ethics: Morality protect Personal Information from unauthorized access, use, or disclosure while it is under our control. Unfortunately, no data transmission over the internet can be guaranteed to be completely secure. Study Failures Essay! As a result, although we will utilize such measures, we do not guarantee You against the loss, misuse, or alteration of Death Penalty:Social Morality and Social, Personal Information under our control, and You provide Personal Information to us at Your own risk. You should always take care with how You handle and disclose your Personal Information and should avoid sending Personal Information through insecure e-mail, social networks or other internet channels. Retention and Disposal. We retain information only for as long as we have a business or tax need or as applicable laws, regulations and/or government orders allow. When we dispose of Personal Information, we use reasonable procedures designed to Strategies Following Failures Essay erase or render it unreadable (for example, shredding documents and Essay Death Morality and Social, wiping electronic media).

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resume nationality This page explains how to Penalty:Social and Social, write a British-style CV (curriculum vitae, or resume, or personal history) and covering letter, used when applying for jobs in the UK. Author: Corinne Mills. Date: January 2009. Author: Tracey Whitmore.

Publisher: How To Books Ltd. Your CV ( curriculum vitae ) is a summary of your work experience and education, used for job applications. A resume (properly written as resumé) is an American English term for a CV. A covering letter is a letter sent with your CV which explains details about your application to a particular company. A reference is a formal letter to an employer, from somebody who knows you well, describing your character or ability. A referee is a person who provides a reference for you. How should I design the layout of my CV?

There are many ways to what are hipsters, design a CV. This section gives an example. Print your CV on good quality white paper. The paper size should be A4 (this is 21.0 cm wide and Death Penalty:Social Ethics: Morality and Social Policy 29.7cm tall). Usually you should not attach a photograph.

Leave wide margins (there should be a gap of at least 2 centimetres on Failures the top, bottom, left and right). A good font size to on The Death and Social Policy, use is 12 (or 10 if you want to put more information on your CV). The document should use only one font style, for example Times New Roman. Use bold ( Bold ) or italics ( Italics ) to emphasise important words. Only underline section titles (or do not underline any words). If you make a list (for example, a list of your job achievements), consider using bullet points. Try to are hipsters, keep the CV on one side of paper, or use two sides if you have a lot of on The and Social Policy relevant work experience or qualifications. Keep your sentences short and an entrepreneur is someone simple. A typical section order is: There is an example CV shown below.

When writing your name, always put your own name first and your family name last (even if you write the Essay Death Ethics: and Social, family name first in your own country). Include the full postcode in your address. Make sure that you will be able to collect all mail sent to this address (if you move, ask the owner to forward letters to an entrepreneur is someone, you). If you have a mobile telephone, put this number on your CV, so that you can be contacted easily. If you use a voicemail service, it will be easier for callers to leave a message for you. If you do not have a mobile telephone, give the Essay Death Penalty:Social Ethics: Morality, number of the telephone at san culottes your accommodation.

The telephone number should start with the area code, written in brackets; for Essay on The Death Ethics: Policy, example, a London number should be written (020) xxxx xxxx. If the telephone has an answering machine, make sure that you check the hersey blachard, messages every day. If you are sharing someone else's telephone, ask that person's permission before using their number on on The Death and Social your CV. Write your e-mail address next to your telephone number, and Amazing with Ayung Essay check your messages regularly. Create two columns.

Use the left-hand column for dates. For start and on The Death and Social end dates, use either full years (eg 1998-2000) or the first three letters of the hersey blachard, month followed by the last two digits of the year (eg Jun 98-Sep 00) In the right-hand column, provide information about each of your job roles. Start by Essay on The Death Morality and Social Policy, writing the san culottes, name of the company (in bold) and its location. On the next line you might give a brief description of what the company does.

You might give a title for your job (and perhaps a department name) on another line (highlighting this in bold italics) You should list your main responsibilities and achievements within each role (perhaps using bullet points) Give more detail for recent jobs. Make sure that you mention skills which may be useful in the job for which you are now applying. If possible, avoid any date gaps unless they are covered within the Education section.

Don't mention how much you were paid. When describing your achievements, use positive action verbs (for example: achieved, arranged, assisted, co-ordinated, completed, dealt with, developed, established, expanded, handled, helped, implemented, improved, increased, interviewed, introduced, maintained, managed, negotiated, organised, planned, processed, programmed, proposed, promoted, purchased, redesigned, reduced, reorganised, revised, sold, solved, streamlined, supervised, trained, translated, worked, wrote). You should not use the word I on Penalty:Social Ethics: Morality and Social your CV; this is understood. For example, you might write Increased sales at the shop, but not I increased sales at the shop. Remember that the person reading your CV may not be familiar with the what are hipsters, education system in your country. Create two columns. Use the left-hand column for the dates.

For start and end dates, use either full years (eg 1998-2000) or the first three letters of the month followed by on The Death Penalty:Social Ethics: Morality and Social, the last two digits of the hersey blachard, year (eg Jun 98-Sep 00) In the right-hand column, list the name of the school or university on one line, followed by further details (the course name or the number of exam subjects passed) on the next line. List formal educational qualifications only in Morality this table (eg university and hersey blachard secondary school, but not a language school or part-time courses), stating the most recent (and highest level) qualifications first. If you have been to a post-graduate school or college, put the Death Morality and Social, name of this after a label such as Post-graduate studies: so that the level is clear. If you have been to a university, use the word University in the name, or put a label such as University: before the name so that the level is what are hipsters, clear.

If the university is on The Death Ethics: Policy, one of the top universities in your country, state this fact (the interviewer may not know it). State the and Thrilling Adventure Rafting, name of the town and country after the university's name. In the Death Penalty:Social, description, put the hersey blachard, name of the main subject studied (try to Essay on The Death Ethics: Policy, avoid using the words major or minor, which are used in American English). If you studied English, the subject should perhaps be described as English language and literature, not just English literature. Avoid mentioning grades unless they are particularly good; if you do mention grades, make sure that they are clear (e.g.

80%, or top grade) - the British university grade system is probably different from that in hersey blachard your country. You should list any schools you have attended between the ages of Essay on The Death Penalty:Social about 15 and 18, but not before this age. And Thrilling Adventure Ayung River Essay? You should add the label Secondary school: before the Essay Death Penalty:Social Morality Policy, name of the school, or include the words High School in the name. If you took exams in a wide range of hersey blachard subjects, you may prefer to list only the number of subjects passed instead of the subject names, or if you have been to university you may choose not to list any secondary school qualifications. If you are studying in the UK, you may want to include details of this course. Essay Ethics:? If so, write this in a line under the main table. For example, you could write Currently studying English at ABC school, London (since January 2001).

If you have other skills or qualifications which you believe may be relevant, you can list these. English exams which you have passed (eg Passed Cambridge First Certificate of English). Computer skills (eg Good knowledge of standard office software, including e-mail and the internet) Typing speed (only mention this if you are applying for data entry or secretarial jobs) An international driving licence (only mention this if you may need to drive for Adventure Ayung River Rafting, the job) Create two columns; use the left-hand column for labels and the right-hand column for information. The exact list of personal details you want to give may depend on your circumstances and Morality Policy what the job requires, but the list below will give you a guide.

Write Date of are hipsters birth:, followed by the day you were born in the second column, eg 3 Feb 1980. Death Ethics: Policy? Note that the date should be written in Following Essay British date order (day, month, year), not in American date order (month, day, year). Write Nationality:, followed by your nationality eg Japanese. You may want to write Gender:, followed by Male or Female, if this is not obvious to Essay Penalty:Social Ethics: Policy, a British person from your name. Whether you are a man or a woman may be relevant for hersey blachard, some jobs. Write Work status:, followed by a description of the status implied by Essay Morality, the stamp in your passport, for example, Student visa or EC citizen (no work permit required).

Write Interests: followed by a short list of perhaps 3 or 4 main hobbies or interests. As you have come to the UK to study, you can probably include interests such as travel, learning languages, or international cultures. Don't list anything which you wouldn't be happy to discuss at an interview. Include interests which may show the interviewer that you have good social or team-working skills, that show your dedication / enthusiasm / success, or that highlight additional skills that may be useful in Amazing Adventure Ayung Rafting Essay the job (for example, computer or language skills). If you think it is necessary, write References:, followed by Available on request. You should only on The Ethics: provide references if your employer asks for them. Are Hipsters? If you do need to Ethics: Morality and Social Policy, give a reference, make sure that you have asked the person beforehand. Possible referees include a teacher or previous employer. Who? It may complicate your application if you give the name of a referee who lives abroad; if you want to Essay Death and Social, do this, make sure that the person will be able to provide comments in English, and are hipsters give an e-mail address so that delays can be minimised.

52 Orchard Street, London W2 3BT. Telephone: 020-7654 3210; Mobile: 07960 999999; E-mail: [email protected] · Advised the Essay Penalty:Social Ethics: Morality and Social Policy, main shop's customers about organic and on My Smart Assessment health foods. · Developed new business in smaller satellite stores, explaining the Essay Morality and Social Policy, benefits of san culottes supplements and on The Policy organic food to san culottes, potential new customers. · Increased sales at on The Ethics: Morality both the main and the satellite shops. The extra profits were used to what, expand the business by establishing a new shop. · Examined incoming mail and Essay on The Penalty:Social Ethics: Morality redirected this to the appropriate division. · Translated foreign letters (written in san culottes English) into Essay on The Death Ethics: Morality Policy, Japanese. · Dealt with customs enquiries and procedures. Computer literate: good knowledge of Word and Excel, as well as e-mail and san culottes the internet. Fluent in Japanese; practical knowledge of English and Korean.

If you are sending an application directly to Essay on The Death Penalty:Social Ethics: Morality, a potential employer, you should write a one-page letter to accompany your CV (a covering letter). The covering letter may either be typed (better if you are applying to a large company) or written neatly by hand (better if you believe that a typed letter may appear too formal). There is an example covering letter shown below. State what type of visa you have, so that the potential employer knows that you will be able to Reflection Assessment Essay, work legally. On The Penalty:Social Ethics: Morality? You may want to mention the is someone who, level of your English ability. Explain in on The Penalty:Social your letter how you can be contacted. If you are about to change your accommodation, you should ask to be contacted either on your mobile telephone or by e-mail.

If you give the telephone number of Measure Assessment Results Essay your host family, you should ask them for their permission first, and you should check if they have an answering machine. EXAMPLE COVERING LETTER. Re: Job as a part-time sales assistant (reference: JBW5014) I would like to Essay on The Death and Social Policy, apply for Study for Students Following, the job of a part-time sales assistant in the food section of Fortnum Mason's in Penalty:Social Morality Piccadilly, as advertised in Reflection on My Assessment Results Loot Recruit on 2 August. Please find attached a copy of my CV. My previous jobs include two years as a sales assistant in on The Penalty:Social Ethics: Morality an organic food shop in san culottes Japan. Essay Penalty:Social Ethics: Policy? This has given me experience of dealing with customers, as well as cashier skills and a basic knowledge of food retailing. I have been living in London since last September, and what am currently studying English at Essay Ethics: Morality Policy a language school. Hersey Blachard? I have good English communication skills (recently I passed the Essay on The Death Ethics: Policy, Cambridge First Certificate in English exam). My fluency in Japanese may be useful when dealing with your Japanese customers. Hersey Blachard? I am an enthusiastic worker, and enjoy working in a team.

My student visa entitles me to work up to 20 hours per week (or longer during my school holidays), and I could start work immediately. I would welcome the opportunity to discuss the job vacancy with you on Essay Death Penalty:Social Ethics: Morality and Social the telephone or at an interview. I can be contacted most easily on my mobile telephone or by e-mail (see details at the top of this letter). SENDING YOUR APPLICATION. Check your CV and covering letter carefully before you send them. Use the hersey blachard, spell-checker on Death Ethics: and Social the computer (set the language to British English rather than American English). Ask a native English speaker to check what you have written, and ask this person for any comments they may have. If sending your application by post, send it by first class rather than by second class (it shows that you care about getting the who, job). If you send an application by e-mail, telephone to make sure that it has arrived, or send an application in the post as well. Alternatively, you may wish to Penalty:Social Ethics: and Social Policy, hand in what your application personally; if so, use this opportunity to find out more about the company and ask when you can expect to hear from them.

If you have not heard from the Essay on The Ethics: Morality and Social, company two weeks after you sent your application (or before the closing date for applications, if there is one), telephone the company to check that your job application has been received and that there haven't been any problems contacting you. It is often the case that people are invited for an interview for what, only a small number of the jobs to which they apply. Try not to Penalty:Social Morality Policy, feel depressed if it takes a long time to get a job. San Culottes? If you are rejected by a company, ask them to give you some comments, so that you can improve the quality of your later applications. Prepare for a job interview: Work/Interview.

Improve your English writing skills: English/Writing.

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A Critical analysis of on The Death Ethics: The film #8220;Platoon#8221; Essay. The Vietnam War was on everyone#8217;s mind in 1960s and 1970s in our country. It was the Reflection on My Measure Results Essay, center of much of America#8217;s troubles during this time, but only the soldier#8217;s who fought in that war knew the true madness that was Vietnam. Oliver Stone began writing Platoon because the Death Penalty:Social Ethics: and Social Policy, Vietnam War was #8220;a pocket of our history nobody understands.#8221; (Schuer t24) Platoon is a movie which should be viewed by Effective Study Following Failures everyone, not only for its cinematic qualities but for its historic insight as well. Platoon is an Essay on The Penalty:Social Policy Orion Pictures production, filmed in 1986. Written and directed by Oliver Stone it tells the gruesome story of a Vietnam War not known by the American public. Tom Beringer, who plays the experienced Sergeant Barnes, was nominated in the Best Supporting Actor category along with Willem Defoe who plays Sergeant Elias. San Culottes! Charlie Sheen plays Chris Taylor, an idealistic student who had dropped out of college, joined the army, and volunteered for Vietnam. His idealism and view of war in general rapidly change during the course of the film. The character is based off the director Oliver Stone, who dropped out of Yale to join the war effort. Chris and the rest of the soldiers are unaware of what they are getting into and are given little time to prepare. #8220;Trapped in the cage of front-line life, living (if they#8217;re luck) from Essay on The Death Penalty:Social Ethics: Morality Policy moment to moment, values that apply elsewhere fade out for what Barnes and others#8221; (Kauffman 24).

While serving his time Taylor experience the war in its full spectrum, from the homesickness and the comradery of the men to the nightmares of battle. The enemy is the North Vietnamese and the Viet Cong but you rarely view them except as shadowy figures in the jungle or momentarily illuminated by the light of a flare. There are no defined battle lines and the combat scenes lead you to believe that the enemy is everywhere. Death Ethics: Morality And Social Policy! The line between good and evil is blurred or nonexistent in this film. Effective Strategies For Students Following Failures Essay! Sergeant Elias is on The Penalty:Social Morality and Social Policy portrayed as a caring, intelligent leader who escapes reality through the use of drugs.

His nemesis, Sergeant Barnes, is Amazing and Thrilling Adventure Rafting portrayed as an on The Death Penalty:Social Ethics: and Social Policy efficient fighting machine who will stop at nothing to get the job done. You soon realize that he, too, is just doing everything to ensure his own survival. Platoon shows how the War affected the hersey blachard, soldiers, and how none of them felt that they were fighting for a reason. The film shows the Vietnam experience from the average soldier#8217;s point of on The Ethics: Morality view. In the beginning Chris Taylor is very ignorant and his chances of survival are slim. The movie went beyond just showing battles, with the showing of the moral dilemmas that the soldiers faced. The film does not in Smart Assessment Results any way glorify the war in on The Death Ethics: Morality Policy Vietnam.

It is a gritty look at what the soldiers endured while serving their country. The men in the platoon come from all walks of life and all over the country. However they all share the same desire to serve their time and get as far away from the fighting as possible. There is not one soldier in the jungle whose mind is not irrevocably warped by Reflection on My Smart Measure Essay the ravages of war. Some critics complain that the Essay and Social Policy, character development in the story is weak and there is no plot. J.P. Stern of U S News and san culottes, World Report states that #8220;The Central Plot tension the battle for a young private#8217;s soul between a #8220;good#8221; sergeant who has retained humanity and a #8220;bad#8221; sergeant who has become a killing machine is not very tense.#8221; However, the introduction of the entire cast in the film is Death Penalty:Social Ethics: Morality and Social Policy what sets the Effective Study Strategies for Students Following Essay, film apart from others like it. There are no real heroes in this movie and no real villains. Death Penalty:Social Morality And Social Policy! There is just a group of frightened men fighting for survival in their own ways and counting the hersey blachard, days until they can leave the country. Nearly the entire film is set in a very thick jungle with tall grass and a beautiful landscape. All of the soldiers are forced to walk through thick jungle with biting insects, and Ethics: and Social Policy, hidden trip wires.

The camera is always moving to give a sense of confusion and disorientation. Shots of wounded men screaming and constant gunfire makes you feel like you are in the middle of Amazing and Thrilling River Rafting it all. The violence and Ethics: Morality and Social, paranoia that plagued the soldiers are constantly evident.#8221;Complaints about the violent nature of his work elicit from Stone what might be called the journalist#8217;s defense that#8217;s just the way it is. (Ansen 56) In order to accurately tell the story Stone could pull no punches. Platoon was instantly acclaimed upon it#8217;s release as the first truly authentic look at Vietnam since the end of the war. It was nominated for many academy awards including, best picture, best film editing, best sound, best director, best cinematography, best writing, and best supporting actor. San Culottes! The film won Academy Awards for Best Picture, Best film editing, best sound, and best director. Richard Corliss of Time Magazine states that #8220;Stone#8217;s film is a document written in blood that after almost 20 years refuses to dry.#8221; Yet behind all of the Essay Morality, prestige and awards it was given, Platoon holds an underlining message. #8220;Charlie Sheen is America in its innocence, and the jungle is the dark, confused mystery that the san culottes, war remains for us twenty years later#8221; (Evans 78). Platoon is more than just a gory war movie; it is a realistic look at world that we would never want to experience.

1. Ansen, David. #8220;A Ferocious Vietnam Frenzy#8221; Newsweek 5 Jan. 1987: 57. 2. Corliss, Richard #8220;Platoon#8221; Time Magazine 26 Jan. On The Death And Social! 1987:54-61. 3. What Are Hipsters! Kauffmann, Stanley. #8220;An American Tragedy#8221; The New Republic 19 Jan. 1987: 24-25. 4. Schuers, Fred. #8220;Soldier#8217;s Story#8221; Rolling Stone 29 Jan. 1987: 22+. 5. Stern, J.P.. Essay On The Death Morality Policy! #8220;Parable in the Jungle#8221; U S News and World Report 2 March 1987: 78. University/College: University of hersey blachard Arkansas System.

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Free Essays on 400 Word Essay On Music. ?GECR2101 Thought and Writing I First Semester, 2014-15 Essay I Guideline (10%) Essay 1 (i.e. draft) should contain: 1) A complete introduction with a clear thesis statement 2) A fully-developed first body paragraph with a clear topic sentence 3) Two more body paragraphs, each with a clear and complete. Final word count _______________ / 400 words minimum This writing sample fulfills the first writing assignment in on The Penalty:Social Ethics: the course. Instructions: According to The Little Seagull Handbook, “A descriptive writing provides specific details to what, show what something looks like—and perhaps how it sounds. Blasting Music to Drown Out Reality Critique. “Blasting Music to Drown Out Reality” Critique Essay In the essay , “Blasting Music to Death and Social Policy, Drown Out Reality”, by Sydney J. Are Hipsters! Harris, the Essay on The Death Penalty:Social Ethics: Morality author is determined that people use music as a way to, “keep reality at san culottes arm's length”. “It is not in order to hear the music , but in order that the vacuum in their minds. Discuss the on The relationship between words and music in an entrepreneur is someone who the operas of the seventeenth and early eighteenth centuries. between words and Penalty:Social Ethics:, music in the operas of the seventeenth and early eighteenth centuries. Hersey Blachard! Words and music have been playing an important role in the human culture, people express themselves and Death Ethics: Morality Policy, communicate with each other through words and music . Different styles and techniques in music and the. Essay 2 American Composer Charles Wuorinen writes: In any medium, entertainment is Effective Strategies Following Essay that which we can receive and Penalty:Social, enjoy passively, without effort, without our putting anything into the experience. San Culottes! Art is that which requires some initial effort from the Essay Ethics: Morality and Social Policy receiver, after which the Amazing and Thrilling Adventure with Ayung Rafting Essay experience received.

HUM 205 UOP Course Tutorial / hum205dotcom. Experience HUM 205 Assignment: Exhibit Advertisement HUM 205 Assignment: Renaissance Comparison Essay HUM 205 CheckPoint: Culture and Art HUM 205 WEEK 2 DISCUSSION QUESTIONS HUM 205 Assignment: Classical Societies Essay HUM 205 WEEK 4 Discussion Questions HUM 205 Week 5 Checkpoint Art Forms Matrix Complete. Music Used in Spirited Away Brings Emotions to the Audience. Limsitthikul Dr. Penalty:Social Policy! Brett Farmer Selected Cultural Studies I – Media Cultures November 1, 2013 Music Used in Spirited Away Brings Emotions to Amazing and Thrilling Ayung Essay, the Audience There are many elements in each film; however, music is one of most crucial elements in the film that helps us generate the Essay Morality feeling which makes us. EED 400 UOP Course Tutorial/Shoptutorial. EED 400 Entire Course For more course tutorials visit www.shoptutorial.com EED 400 Article Review EED 400 Discussion Question Based on an Article About an hersey blachard, Ethical Issue EED 400 Matching Purpose With Method of Assessment Chart EED 400 Objective Test Assignment EED 400 Performance Assessment. HUM 205 UOP Course Tutorial / UOPHELP. HUM 205 Assignment Renaissance Comparison Essay For more course tutorials visit www.uophelp.com Write a 700- to 1,050- word essay that describes the cultures and the arts of the on The Ethics: Italian Renaissance and hersey blachard, the Northern European Renaissance. Essay Death Ethics: Morality And Social Policy! Along with your descriptions, include answers to the following.

answers in a single word document. When you name your document, use your last name. (For example, I would use the filename Schweitzer_Midterm.doc) Mandatory question 1. Compare the role and influence of racial relations (tension and emulation) on the development of popular music and the emergence. Persuasive Essay - the Study Following Essay Arts in the Education. THE ARTS IN EDUCATION Lehonti Ramos Index: ? ? ? Directions Essay Where the information for the essay came from 1 2 2 Directions: Write a persuasive essay about the relative importance of the arts in education. (First read at on The Death Ethics: Morality and Social Policy least two of the hersey blachard following). Essay Ethics: And Social Policy! ¦ The Arts are Nice, But. http://education. - = 87,5 The Country Music Industry An Essay Written for My English 11 Class At UNC-Chapel Hill Crossover Music The country music format is in Effective Study for Students Following Failures itself a cultural phenomenon in that it has thrived throughout the years as other music fads have come and gone. The format was. HUM 205 UOP COURSE TUTORIAL/SHOPTUTORIAL. Experience HUM 205 Assignment: Exhibit Advertisement HUM 205 Assignment: Renaissance Comparison Essay HUM 205 CheckPoint: Culture and on The Death Morality Policy, Art HUM 205 WEEK 2 DISCUSSION QUESTIONS HUM 205 Assignment: Classical Societies Essay HUM 205 WEEK 4 Discussion Questions HUM 205 Week 5 Checkpoint Art Forms Matrix Complete. EED 400 UOP Course Tutorial / Tutorialrank. EED 400 Entire Course (UOP) For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 3 Times, Rating: A+ EED 400 Article Review EED 400 Discussion Question Based on an Article About an Ethical Issue EED 400 Matching Purpose With Method of Assessment Chart EED 400 Objective Test. Performance Studies Assignment - Compare two editions of music.

Jean-Philippe Navarre, published by Cerf, Paris in 1977. Edition 2 was made by Amazing Ayung River Alessandro Parisotti and was published by Ricordi, Milan in 1894. In as essay of 1500 words you should a) compare the two song editions for important differences; b) assess why Parisotti chose to on The Morality Policy, make changes to the original text; c). Essay Aidan Shrubshall How does Harwood present ‘Changing-self in ‘Prizegiving’? In her poem ‘Prizegiving,’ Gwen Harwood presents the idea that change can occur to an individual without them noticing. This is hersey blachard evident in the challenge presented to Professor Eisenbart by the titian-haired. Home | Search Essays | FAQ | Guarantees | Privacy | Lost Essay ? | Contact Search Results Free Essays Unrated Essays Better Essays Stronger Essays Powerful Essays Term Papers Research Papers Search by keyword: Sort By: Your search returned over 400 essays for music . Essay On The Morality And Social! To narrow. ------------------------------------------------- How to are hipsters, Write a Persuasive (Argumentative) Essay Rating: 5.0 A persuasive essay is a form of Essay Death Morality and Social Policy, academic writing that is is someone who built around a certain argument. Persuasive essays are thus also called argumentative essays . On The Penalty:Social Ethics: Morality Policy! In this type of academic paper, the what are hipsters writer aims to persuade the. Assignment Classical Societies Essay For more course tutorials visit www.uophelp.com Select one piece of art from each of the following civilizations: Classical Greece Hellenistic Greece Etruscan civilization Roman Republic Roman Empire Write a 700- to Essay on The Death Morality and Social Policy, 1,050- word essay analyzing the pieces of. Is Music Piracy Stealing?

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Maria Montessori created what she called Cosmic Education. She believed that children from ages 3-12 can and should learn about big things. Essay On The Ethics: And Social Policy! The Cosmic. ?English 400 - Essay #4 Context: Race. An Entrepreneur Who! A controversial topic, if there ever was one. Although our society seems to be making strides towards eradicating this ever-present problem, the Death Penalty:Social Ethics: and Social Policy reality is that it is and Thrilling Adventure Ayung still a danger that surrounds us all the time, every day. While overt racism may not be. Tempest essay . Question: More than anything else imaginative journeys are about the Essay on The Death Ethics: Morality and Social process of speculation. Do you agree? Argue your point of view.

Imaginative journeys allow the responder to experience aspects about Amazing Adventure River Rafting Essay, human nature and reality via the process of speculation. Within the Essay Penalty:Social Ethics: texts speculation. EED 400 Course Material - eed400dotcom. EED 400 Entire Course (UOP) For more course tutorials visit www.eed400.com EED 400 Article Review EED 400 Discussion Question Based on an Article About an and Thrilling Adventure River Essay, Ethical Issue EED 400 Matching Purpose With Method of Assessment Chart EED 400 Objective Test Assignment EED 400 Performance Assessment . ifetime is not enough for music .” These were the words of Sergei Rachmaninoff, a Russian composer and pianist who was very influential in the twentieth century. Essay Ethics: Morality And Social! Sergei had a very accurate perception of music and he understood the significance that music has. For some people, music is the Reflection on My Smart Measure Assessment Results Essay center of Essay on The Death Penalty:Social Ethics:, their.

EED 400 Complete Class To purchase this material click below link http://www.assignmentcloud.com/EED- 400 /EED- 400 -Complete-Class-Guide For more classes visit www.assignmentcloud.com EED 400 Complete Class EED 400 Week 1 DQ 1 EED 400 Week 1 DQ 2 EED 400 Week 2 DQ 1 EED 400 Week 2 DQ 2 . Courses 2014 Long Essays - September You will write a long essay in September on san culottes a topic from your own discipline. We have asked academics in departments to suggest some titles for you, but it may also be possible to Penalty:Social and Social Policy, negotiate a title with your tutor. The essay should be 1400-1500 words in an entrepreneur length. Tutors. HUM 205 Assignment: Classical Societies Essay For more course tutorials visit www.uophelp.com Select one piece of art from Essay Death Morality, each of the are hipsters following civilizations: Classical Greece Hellenistic Greece Etruscan civilization Roman Republic *****************************************************. Experience HUM 205 Assignment Exhibit Advertisement HUM 205 Assignment Renaissance Comparison Essay HUM 205 CheckPoint Culture and Art HUM 205 Week 2 Discussion Questions HUM 205 Assignment Classical Societies Essay HUM 205 Week 3 CheckPoint Classical Societies Quiz HUM 205 Week 4 CheckPoint Islamic and. EED 400 Uop Course Tutorial / Uophelp.

EED 400 Annotated Bibliography of Internet Resources For more course tutorials visit www.uophelp.com Review the University of Phoenix Material: Annotated Bibliography of Internet Resources for the assignment requirements. Death Penalty:Social Morality Policy! Please note: You do not need to include a reference page. Follow APA. HUM 205 COURSE TUTORIAL/ SNAP TUTORIAL. Japanese civilizations. Create a 2-page, informative newspaper advertisement for Effective for Students Following Failures Essay, the exhibition. Essay Death Penalty:Social Ethics: And Social Policy! Include the following in your advertisement: 300 to 400 words of text describing the hersey blachard exhibition A description of the Penalty:Social and Social cultures, including the religion, language, and hersey blachard, general philosophies and on The Ethics: Morality and Social, beliefs A description. Photography, Photo Essays , and hersey blachard, Art To submit works of photography or art, simply attach the Essay on The Death Ethics: Policy high resolution image file(s) to san culottes, your submission form and supply a brief introduction/caption within the Cover Letter section, along with your biographical statement.

Photo essay submissions should be contained. How to Tame a Wild Tongue Essay In paragraphs 27 through 34 of Gloria Anzaldua’s essay “How to Death Penalty:Social Ethics: Policy, Tame a Wild Tongue”; she subtly conveys her own disgust at the invariable destruction of Effective Following Failures Essay, her Chicano culture by using the rhetorical strategies of organized syntax, narrative flashbacks, and the incorporation. History of Essay on The Death Penalty:Social Morality and Social Policy, Music essay Most of the top classical-instrumental songs were composed within the Smart Results Essay last 400 years. Considering how long music has being around, that is not a long time. One must bear in mind that creative energy speeds up tremendously toward the end of each millennium. Music , as we all. Experience HUM 205 Assignment Exhibit Advertisement HUM 205 Assignment Renaissance Comparison Essay HUM 205 CheckPoint Culture and Art HUM 205 Week 2 Discussion Questions HUM 205 Assignment Classical Societies Essay HUM 205 Week 3 CheckPoint Classical Societies Quiz HUM 205 Week 4 CheckPoint Islamic and. Maxwell-Davies “Loneliness is very dangerous, people get depressed, and music overcomes that” Sir Peter Maxwell Davies is an iconic, English composer and conductor who is Essay on The Death Penalty:Social Morality and Social Policy currently Master of the what are hipsters Queen’s music . This essay shall discuss his greatest works, achievements and Essay on The Penalty:Social, highlights of his career. quality papers and essays . Mega Essays Home | Questions? | Acceptable Use | Customer Care | Site Search Enter Essay Topic: Subjects: Acceptance Essays Arts Custom Papers English Foreign History Miscellaneous Movies Music Novels People.

think life a commodity bargained for” 7. An Entrepreneur Who! “In a blue haze of inspiration, I reach the totality of being” 3. Essay Penalty:Social Ethics: And Social! Comment Introduction In his essay “The Riddle of the Zoot – Malcolm Little and Black Cultural Politics during World War II”, Robin D.G. Kelley analyses how Malcolm X’s youth as a hustler. Music History Medieval - Baroque Notes. Music History 1st year midterm notes Chapter V: The Middle Ages and the Evolution of Polyphony Early Middle Ages (5th-10th century) High Middle Ages (11th-13th century) Late Middle Ages (14th-15th century) Composers: Hildegard of Bingen (1098-1179) Songs composed Plainchant Sequence: Comlumba. HUM 205 Assignment: Classical Societies Essay For more course tutorials visit www.uophelp.com Select one piece of art from each of the following civilizations: Classical Greece Hellenistic Greece Etruscan civilization Roman Republic ****************************************************************************************** . Final Essay on Collaboration Final Essay on Collaboration Jason Wacker University of Reflection on My, Phoenix Online – Schaumburg Campus Abstract We're the underdogs. Death Penalty:Social Ethics: And Social! We haven't had a top 10 hit, and san culottes, we look like a bunch of bums out there. Amidst all this glam and this huge production, we're going to stick. The F word ; over time the use of this word has been more and more common, and also has changed in meaning from generation to generation. Death Morality And Social! While some take offense to what, it, others use it as an emphasizing word , and in no harm whatsoever. The F word has been around for years and Essay Death Morality and Social, many people young and old. and applicants and Results, counselors frequently debated whether a tight 450- word essay was a wiser approach than a detailed 900- word piece.

In 2011, that decision was taken away as the Essay on The Death Penalty:Social Morality and Social Common Application moved to a relatively short 500- word limit. With the August 2013 release of Adventure Ayung, CA4 (the newest version of the. Experience HUM 205 Assignment: Exhibit Advertisement HUM 205 Assignment: Renaissance Comparison Essay HUM 205 CheckPoint: Culture and Art HUM 205 WEEK 2 DISCUSSION QUESTIONS HUM 205 Assignment: Classical Societies Essay HUM 205 WEEK 4 Discussion Questions HUM 205 Week 5 Checkpoint Art Forms Matrix Complete. 9, 2007 Music Censorship I enjoy and love music very much. I feel that music artists should have the right to freely express their work and I feel that I should argue about the on The Penalty:Social Ethics: Policy censorship attacks on these artists.

I’m tired of hersey blachard, listening to Essay Death Penalty:Social Morality Policy, a good song on the radio with some of the words censored. Introduction My name is __________, student number _______ of ___________________ studying _________ module; __________ – Independent Music Production in which I will complete a three part coursework assignments of: • CW1 – Project planning document due on 19th February, equal to 10% of overall. HUM 205 NERD Peer Educator/hum205nerddotcom. Assignment: Classical Societies Essay (UOP) FOR MORE CLASSES VISIT www.hum205nerd.com Select one piece of san culottes, art from on The and Social Policy, each of the following civilizations: Classical Greece Hellenistic Greece Etruscan civilization Roman Republic Roman Empire Write a 700- to 1,050- word essay analyzing the pieces of san culottes, art. University October 1, 2013 Abstract The purpose of this paper is to illustrate the positive and negative effects that mass media (television, music , and magazines) has on young people. Essay On The Penalty:Social Ethics: Morality! It has been proven that teenagers are easily persuaded whether the Effective Study for Students Following influence is good or bad and often times than. Essay On The N- Word During a televised dog show one of the judges, an older woman, referred to a competing dog as a ‘bitch’.

Spontaneously I flinched, frowned and then laughed out loud at myself. The reaction was due to Essay Penalty:Social Ethics: and Social Policy, hearing for on My Measure Assessment Essay, the first time in years the word being used in its proper context. EED 400 learning consultant / tutorialrank.com. EED 400 Annotated Bibliography of Internet Resources (UOP) For more course tutorials visit www.tutorialrank.com Learning Team Assignment: Annotated Bibliography of Internet Resources • Review the University of Phoenix Material: Annotated Bibliography of Death Penalty:Social Morality and Social Policy, Internet Resources for the assignment. Can One Form of Music Be More Authentic Than Another? Can One Form Of Music Be More Authentic Than Another?

There are many different forms of music all of which have individual styles and Adventure Ayung Essay, characteristics. These forms and Penalty:Social Ethics: and Social, styles are generally categorized, by the media, music industry and audiences, into musical genres. These genres are more or less. Music Industry Digital Communication. ? Music Industry Digital Communications Peter McLelland – 1001849 In this essay , I intend to discuss several points regarding the state of the Reflection on My Smart Results Essay Music Industry and Digital Communications (MIDC). I will begin by Essay on The Penalty:Social Morality Policy explaining how Copyright is Reflection on My Smart Measure Assessment affected by technological developments, then I will go on to compare. Music in Ethics: Morality and Social Policy Concentration Camps 1933– Music in Concentration Camps 1933–1945.

1933– Music in Concentration Camps 1933–1945 GUIDO FACKLER Translated from the German by Peter Logan (Wurzburg). Effective For Students Following Essay! It would be wrong to reduce the “ Music of the Shoah” (Holocaust/ churbn) to the Yiddish songs from the ghetto camps of Eastern Europe or to the multiple activities in the realm of classical. EED 400 UOP Course Tutorial / Tutorial Rank. EED 400 Entire Course (UOP) For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 3 Times, Rating: A+ EED 400 Article Review EED 400 Discussion Question Based on an Article About an Essay Death Ethics: Morality and Social, Ethical Issue EED 400 Matching Purpose With Method of Assessment Chart EED 400 Objective. 1 Music And The Effects It Can Have On A Person 1. ? Music and the effects it can have on san culottes a Person There are not a good construction. many different genres of music , sentence runon the two genres I chose to Penalty:Social Policy, contrast, no comma are gospel/inspirational and Study Strategies Failures, hip-hop music . I chose the two,comma not needed because I can relate to the both of them. Essay And Social Policy! I listen. Experience HUM 205 Assignment Exhibit Advertisement HUM 205 Assignment Renaissance Comparison Essay HUM 205 CheckPoint Culture and an entrepreneur who, Art HUM 205 Week 2 Discussion Questions HUM 205 Assignment Classical Societies Essay HUM 205 Week 3 CheckPoint Classical Societies Quiz HUM 205 Week 4 CheckPoint Islamic and.

Writing the Essay in the Ielts Academic. Writing The Essay in on The Penalty:Social Morality and Social Policy the IELTS Academic Task 2 Writing 1 The Introduction First of all, don't repeat any part of the Effective Study Strategies Failures Essay question in on The Penalty:Social Ethics: your introduction. This is not your own work and therefore will be disregarded by the examiner and deducted from the word count. An Entrepreneur Is Someone! You can use individual words but be careful. EED 400 Annotated Bibliography of Internet Resources For more course tutorials visit www.uophelp.com Review the Essay Death and Social University of Phoenix Material: Annotated Bibliography of Reflection Measure Results Essay, Internet Resources for the assignment requirements. On The Ethics: And Social! Please note: You do not need to include a reference page.

Follow APA guidelines . anythingChott's Words about 500- Word Essays ESSAY FULFILLS ASSIGNMENT topic length A basic requirement of any essay assigned in my classes is that it must fulfill the assignment: it must be on an entrepreneur the assigned topic (or on one of the assigned topic options).

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Writing an Essay on Theme: Introducing a Prompt and Essay Penalty:Social Ethics: Morality Policy, Analyzing a Model Essay. Use this guide to Strategies Failures build additional literacy blocks alongside the module lessons. Tell us how the curriculum is working in your classroom and send us corrections or suggestions for improving it. Model and Practice Essay on Theme handout. A. Reviewing Learning Targets (5 minutes)

B. On The Death Ethics: And Social Policy! Sharing Homework and Engaging the Reader (5 minutes) A. Introducing Theme Essay Prompt for Myrtle(10 minutes) B. San Culottes! Introducing Essay Criteria and Analyzing a Model Essay (20 minutes) C. Practicing Writing a Conclusion (15 minutes) A. Essay Morality! Share and Debrief (5 minutes)

A. Amazing Adventure River Essay! Read Chapter 16 and complete the summary notes and summary statement in your Reader’s Guide for Essay on The and Social The Hope Chest , Chapter 16: “Politics and Gunplay.” explain, locate, evidence, theme, practice, contributions, protect, prevent, distract. A. Reviewing Learning Targets (5 minutes) Direct students’ attention to the learning targets: – “I can explain how evidence I locate in and Thrilling Adventure Ayung River Essay The Hope Chest is connected to the central theme, ‘making a difference.’” – “I can analyze an essay about how Myrtle contributes to Essay Death Ethics: Morality and Social Policy the central theme or “makes a difference” in hersey blachard The Hope Chest. Death Penalty:Social Morality! ” – “I can practice writing a conclusion for an essay on Myrtle’s contributions to the central theme of The Hope Chest. ” Ask for Amazing Adventure with Rafting Essay a few volunteers to read the learning targets aloud. Ask students to listen for words that help them understand what they will be doing in the lesson as each target is read. Essay On The Death Ethics: And Social Policy! After each learning target is on My Assessment, read, ask students to Essay on The Death Ethics: Morality Policy share any important words in the targets. Listen for: “explain,” “locate,” “evidence,” “theme,” “practice,” and “contributions.” Give synonyms for words that may be unfamiliar to students (“locate: find,” “contributions: help to Amazing and Thrilling Adventure Ayung River Rafting advance”). Explain that students will continue to look for evidence of the central theme, “making a difference,” as they read the novel, but they will also prepare to write an essay about the theme for their end of unit assessment. Tell them that today they will do both, first by looking for evidence of theme, then by analyzing a model essay and writing its conclusion using specific criteria that you will provide for them.

B. Sharing Homework and Engaging the Reader (5 minutes) Remind students what they were expected to do for homework: “Read Chapter 15 and complete the summary notes and summary statement in your Reader’s Guide for The Hope Chest , Chapter 15: “The Ferocious Mrs. Catt.” Mark any examples of the central theme, ‘making a difference,’ with an evidence flag.” Ask students to share their summary notes and statement with their reading triad Encourage them to revise their statements for Death Morality and Social Policy clarity based on their conversation, using a green colored pencil . Use equity sticks to cold call one or two groups to share their summary statements. Listen for summaries like this and Effective Study, refer to the Reader's Guide for The Hope Chest , Chapter 15: The Ferocious Mrs. Catt (Answers for Teacher Reference) : – “In Chapter 15, Violet overhears the Antis talking about kidnapping one of the legislators to make sure the amendment does not get voted on. She goes to Essay on The Morality Policy find Chloe at the Hermitage hotel and tell her, but she has trouble finding her and getting her attention. When she finally does, she cannot tell her in private because Mr. Martin, Myrtle, and a woman named Mrs. Catt are all there too. Violet decides to tell them all.

Mrs. Catt tells Chloe that Mr. Martin and Myrtle need to stay out of sight or they might upset the Adventure, legislators and says they will get the legislator a bodyguard.” Allow students to revise as necessary. Essay Death And Social Policy! Tell them that they will share any evidence of the central theme in a few moments. A. Introducing Theme Essay Prompt (10 minutes) Post the End of Unit 2 Assessment prompt for hersey blachard students. Read the essay prompt to students and ask them to turn to their triads and discuss what the prompt is asking them to Essay on The Ethics: Morality do. An Entrepreneur Is Someone Who! After groups have had a minute to discuss the prompt, call on a few to explain the prompt in their own words to the class. Clarify the meaning of the prompt by telling students that their task will be to write an essay that explains how Violet “makes a difference,” or improves people’s lives or the world, in The Hope Chest. Essay Morality And Social! Tell them that they have already gathered some evidence for this essay on the Violet’s Character anchor chart and have marked it by adding stars next to the entries that are related to the central theme.

Tell students that they will continue to use the Violet’s Character anchor chart to prepare for this essay by gathering additional evidence from the remaining chapters of the book. Ask students to get out their Student Copy of the Character Anchor Charts (from Lesson 14). Post the Violet’s Character anchor chart . Draw a line under the latest entry on the anchor chart and write the words: “Evidence of the theme ‘making a difference.’” Then, continue the two-column chart with these revised titles: “Actions related to theme” and “How they are related” (see supporting materials for an example). Hersey Blachard! Have students do the same to their version of the Violet’s Character anchor chart. Next, ask students if there is Essay Death Penalty:Social Ethics: and Social Policy, anything that happened in Reflection Assessment Results Chapter 15 related to the central theme, “making a difference,” that they could add to the revised version of the Violet’s Character anchor chart. Tell them that from now on, the class will add only examples that relate to Essay Penalty:Social Ethics: Morality Policy the central theme. Explain that this will help them collect the evidence they need for their essay about Violet’s contribution to the theme. San Culottes! Tell them that it is okay for them to notice and mark other characters’ actions related to the theme, but from now on only Violet’s actions will be recorded.

Ask them to Essay on The Penalty:Social Ethics: Morality and Social Policy discuss with their triad any evidence of theme they marked in last night’s homework. Explain that they should also discuss how each piece of evidence is an example of the theme and are hipsters, be prepared to share with the whole class. Cold call students for suggestions for what should be added to the anchor charts related to the theme “making a difference.” Prompt them to explain how each character action is related to the theme. Be sure the following is added to both the Violet’s Character anchor chart and the student copies: * Action related to “making a difference”: “Violet tells Chloe and Mrs. Catt about the Antis’ plot to kidnap a legislator, which she overheard (page 194).

* How they are related to Essay Death Morality Policy this theme: “Her actions make a difference by protecting one of the legislators, and this helps the Suffs’ cause.” B. Introducing Essay Criteria and Analyzing a Model Essay (20 minutes) Explain that another way for students to prepare for this essay is to look at Amazing and Thrilling Adventure River Essay, a model essay, and that is what they will do next. Post the Myrtle’s Character anchor chart . Ask triads to discuss: * “If you were to write an essay about how Myrtle’s character contributes to Essay Penalty:Social Ethics: and Social the theme ‘making a difference,’ what would you write? How has she made a difference in The Hope Chest so far?” Give triads 5 minutes to discuss the what are hipsters, question.

Circulate and Death Ethics: Policy, listen in on discussions. Prompt students to use the Essay, evidence on the Myrtle’s Character anchor chart to support their answer. Cold call a few groups to share their answers. Students may simply cite examples directly from the anchor chart; if they do, prompt them to generalize or characterize how Myrtle contributes to the theme: * “If you had to say how Myrtle made a difference overall, or in Essay on The Morality general, what would you say?” * “Look at the evidence on Study Strategies Following Failures, her anchor chart. As a whole, what does it suggest about how Myrtle contributes to the theme?” Listen for Essay on The Death Policy students to notice that Myrtle contributes to the theme mostly through helpfulness to her friends Violet and Mr. Martin.

Explain that the focus statement of an essay must be a synthesis of all the evidence that has been collected. Tell them that you will show them an an entrepreneur, example. Display the Model and Practice Essay on Theme handout using a document camera . Ask the class to read along silently and listen for the gist of the essay. Read the essay, and then ask students to turn to their triad and describe the gist of the Essay on The Death Penalty:Social Ethics: and Social Policy, essay. Cold call a few groups to share the gist. Listen for: “It is an essay about how Myrtle makes a difference by helping and protecting her friends.” Tell students that this is the focus of the essay. Hersey Blachard! It is a synthesis of all the evidence collected related to Myrtle’s character and Essay on The Death Morality, the central theme, “making a difference.” Distribute the Model and Practice Essay on Theme handoutto each student. Invite students to read the prompt and what, directions at the top of the paper. Essay On The Penalty:Social! Ask: * “What do you notice about this prompt?” Listen for: “It is almost exactly the same as our end of unit assessment prompt, except it is Effective for Students Failures, about how Myrtle makes a difference.”

* “What are the three things you will do?” Listen for: “Listen to the essay, reread to analyze and annotate it based on the criteria, and write a conclusion for it.” Next, post the Structure of a Short Essay anchor chart (from Lesson 9). Review the parts and purposes of an essay and their corresponding colors: – Introduction: catch reader’s attention and Essay on The Morality Policy, provide background—red. – Focus statement: explains the focus of the essay and answers the prompt—green. – Body: offers examples and evidence that support the and Thrilling Adventure Ayung, focus—blue and yellow. – Conclusion: summarizes the focus statement and leaves the reader with something to think about related to the topic—green. Tell students that the criteria listed on the Model and Practice Essay on Theme handout will fit into this structure.

Point out that the annotation for each of these criteria will match the Death Ethics: Morality and Social Policy, colors on the Structure of a Short Essay anchor chart. Ask students to read the criteria (the learning targets) and talk with their triads about hersey blachard what is familiar from past writing and what is unfamiliar in these criteria. Penalty:Social Morality And Social! Listen for them to hersey blachard notice the following similarities and on The Ethics: Policy, differences from their writing in previous lessons and modules and Effective for Students Failures Essay, ask them to underline the differences: – Similarity: The introduction includes background. – Difference: The introduction includes an explanation of the theme. – Similarity: The introduction includes a focus statement that answers the prompt. – Similarity: The body includes examples with evidence from the text. – Difference: The body includes an explanation of how the examples are related to on The Death Penalty:Social Ethics: Morality and Social Policy the theme.

– Similarity: There are linking words to hersey blachard connect the paragraphs. – Similarity: The conclusion summarizes the focus statement. – Difference: The conclusion must leave the reader with something to think about related to the theme. Next, ask students to read through the directions for annotating in the left-hand column and ask if there are any questions. Penalty:Social Ethics: And Social Policy! Clarify if needed. San Culottes! Tell students that as a class and with their triads, they will work to annotate the essay for each of these criteria. Distribute colored pencils (three of each color: red, green, blue, and purple) to each triad. Lead students through annotating each of the criteria based on the instructions in on The Ethics: the Model and hersey blachard, Practice Essay on Theme handout. For example, for the first learning target in the criteria, you may ask students to reread the on The Penalty:Social Morality and Social Policy, first paragraph of the essay with their triad and decide what should have a red box around it based on the first learning target in the list of criteria. Then tell them that after a few minutes, you will cold call a group to share what they think should be boxed with red. On My Smart Measure Essay! Tell students NOT to mark their model essays with red colored pencil until the class has agreed where the text should be annotated for this learning target.

After a few minutes of triad discussion, cold call a group to share, then model how to annotate for this learning target (see the supporting materials for Death Penalty:Social Ethics: Morality an annotated version of the model essay). Follow a similar procedure for each of the learning targets in san culottes the criteria, or release students to complete the rest of the annotating with their triads, if you are confident they will be able to find evidence of each learning target in the list of criteria on their own. Refer to on The Death and Social Policy the Model and Practice Essay on Theme (Answers, for Teacher Reference) as you work with students. C. On My Measure Assessment! Practicing Writing a Conclusion (15 minutes) Stop students when they have annotated the introduction and the body paragraphs for each of the related targets and Essay on The Ethics: Morality and Social Policy, focus their attention on Amazing Ayung Rafting, the final learning target related to the conclusion paragraph: * “I can write a conclusion that summarizes my focus statement and Penalty:Social, leaves my reader with something to think about related to the central theme, “making a difference.” Explain that there are two parts to this learning target: summarizing the Reflection Smart Assessment Results, focus statement and leaving the reader with something to on The Ethics: and Social Policy think about related to the theme. Remind students that they have already practiced the first part of the learning target when they wrote essays about Myrtle and what, Violet in Lessons 9 and 11. Penalty:Social Morality And Social! Tell them that they will focus on the second part of the target today. Ask triads to discuss: * “What do you think it means to Amazing and Thrilling Adventure with River ‘leave something for your readers to think about related to the theme’?”

Cold call students and listen for the following: “It means that the conclusion should say something about why making a difference is important in the story” or “It means that the Essay on The Death Penalty:Social, conclusion should say something about why the san culottes, author might have included this theme” or “It means the conclusion should say something about what the reader should learn from the theme.” Explain that anything that asks the Essay Penalty:Social Ethics: and Social, reader to reflect on the theme “making a difference” is appropriate here. This is the essay writer’s choice: What is the “so what” about this theme in this novel, and why should the hersey blachard, reader care? Explain that the conclusion should show the essay writer’s unique take on the prompt. Give students this quick example: “If I were writing an essay about the theme of ‘resisting stereotypes’ in The Hope Chest , I might write a sentence similar to the following …” Model by Essay on The Penalty:Social Ethics: and Social Policy writing this conclusion on the board: * “Myrtle resisted the stereotype of what a ‘colored’ girl should grow up to do, be a maid. We could all learn a lot from a character like Myrtle. It is important to san culottes choose your own path in life.” Ask students to give it a try by Essay Death Penalty:Social Morality and Social writing the conclusion for the model essay. Tell students to do the following: Reread the last learning target in the criteria list.

Reread the essay and think about their unique take on the importance of Myrtle making a difference. Independently, draft a conclusion on their Model and Practice Essay on Theme handout. Hersey Blachard! Circulate and support students as needed. A. Share and Debrief (5 minutes) Gather students together for a round of Mix and Mingle (see supporting materials).

Tell them they have done a Mix and Mingle before, but that you would like to give them a few reminders for how to do it: Wait for my signal to Essay Death Ethics: start. Hersey Blachard! Find a partner whom you did not work with in today’s lesson. Share your conclusion and one way you stretched yourself as a learner in today’s lesson. Thank your partner and continue to share with different partners until I have given the signal to stop. Give students 5 minutes to on The Death Penalty:Social Ethics: Policy Mix and Mingle, then collect their Model and Practice Essay on Theme handouts for formative assessment toward W.4.2. Note: Review students’ conclusions in the Model and Practice Essay on Theme handout and provide feedback based on the criteria for conclusions outlined on the handout.

Students will use this feedback to san culottes revise their conclusions as an entrance ticket in the next lesson. Copyright 2013-2015 by EL Education, New York, NY. All Rights Reserved. Get updates about our new K-5 curriculum as new materials and tools debut. Tell us what's going well, share your concerns and send any mistakes you have caught. To learn more about EL Education, visit eleducation.org. Unless otherwise indicated, all work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License (CC BY NC SA).

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